JPH0439315B2 - - Google Patents
Info
- Publication number
- JPH0439315B2 JPH0439315B2 JP14110585A JP14110585A JPH0439315B2 JP H0439315 B2 JPH0439315 B2 JP H0439315B2 JP 14110585 A JP14110585 A JP 14110585A JP 14110585 A JP14110585 A JP 14110585A JP H0439315 B2 JPH0439315 B2 JP H0439315B2
- Authority
- JP
- Japan
- Prior art keywords
- amino acids
- amino acid
- carbamoyl
- reaction
- arthrobacter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001469 hydantoins Chemical class 0.000 claims description 15
- 150000008575 L-amino acids Chemical class 0.000 claims description 13
- 230000001580 bacterial effect Effects 0.000 claims description 12
- -1 N-carbamoyl amino Chemical class 0.000 claims description 8
- 241000186073 Arthrobacter sp. Species 0.000 claims description 6
- 241000186063 Arthrobacter Species 0.000 claims description 3
- 241000894007 species Species 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 10
- 244000005700 microbiome Species 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 9
- 229940091173 hydantoin Drugs 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000002994 raw material Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000002689 soil Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
- 229930195722 L-methionine Natural products 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000006911 enzymatic reaction Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229960004452 methionine Drugs 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- QYASYXWODYQOFU-UHFFFAOYSA-N 5-(1h-indol-2-ylmethyl)imidazolidine-2,4-dione Chemical compound O=C1NC(=O)NC1CC1=CC2=CC=CC=C2N1 QYASYXWODYQOFU-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000192130 Leuconostoc mesenteroides Species 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- DEWDMTSMCKXBNP-BYPYZUCNSA-N N-carbamoyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC(N)=O DEWDMTSMCKXBNP-BYPYZUCNSA-N 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- NWLXJVDJMARXSP-SNVBAGLBSA-N (2r)-2-(carbamoylamino)-3-(1h-indol-3-yl)propanoic acid Chemical compound C1=CC=C2C(C[C@@H](NC(=O)N)C(O)=O)=CNC2=C1 NWLXJVDJMARXSP-SNVBAGLBSA-N 0.000 description 1
- PNLKYZVGQWCHBH-MRVPVSSYSA-N (2r)-2-(carbamoylamino)-3-(4-hydroxyphenyl)propanoic acid Chemical compound NC(=O)N[C@@H](C(O)=O)CC1=CC=C(O)C=C1 PNLKYZVGQWCHBH-MRVPVSSYSA-N 0.000 description 1
- NWLXJVDJMARXSP-UHFFFAOYSA-N 2-(carbamoylamino)-3-(1h-indol-3-yl)propanoic acid Chemical compound C1=CC=C2C(CC(NC(=O)N)C(O)=O)=CNC2=C1 NWLXJVDJMARXSP-UHFFFAOYSA-N 0.000 description 1
- DEWDMTSMCKXBNP-UHFFFAOYSA-N 2-(carbamoylamino)-4-methylsulfanylbutanoic acid Chemical compound CSCCC(C(O)=O)NC(N)=O DEWDMTSMCKXBNP-UHFFFAOYSA-N 0.000 description 1
- WLRZLHCGXUHRIG-UHFFFAOYSA-N 5-(2-methylpropyl)imidazolidine-2,4-dione Chemical compound CC(C)CC1NC(=O)NC1=O WLRZLHCGXUHRIG-UHFFFAOYSA-N 0.000 description 1
- SBKRXUMXMKBCLD-UHFFFAOYSA-N 5-(2-methylsulfanylethyl)imidazolidine-2,4-dione Chemical compound CSCCC1NC(=O)NC1=O SBKRXUMXMKBCLD-UHFFFAOYSA-N 0.000 description 1
- GLLIXWMNULCIKR-UHFFFAOYSA-N 5-[(4-hydroxyphenyl)methyl]imidazolidine-2,4-dione Chemical compound C1=CC(O)=CC=C1CC1C(=O)NC(=O)N1 GLLIXWMNULCIKR-UHFFFAOYSA-N 0.000 description 1
- DBOMTIHROGSFTI-UHFFFAOYSA-N 5-benzylimidazolidine-2,4-dione Chemical class O=C1NC(=O)NC1CC1=CC=CC=C1 DBOMTIHROGSFTI-UHFFFAOYSA-N 0.000 description 1
- PBNUQCWZHRMSMS-UHFFFAOYSA-N 5-propan-2-ylimidazolidine-2,4-dione Chemical compound CC(C)C1NC(=O)NC1=O PBNUQCWZHRMSMS-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 241000589565 Flavobacterium Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- DEWDMTSMCKXBNP-SCSAIBSYSA-N N-carbamoyl-D-methionine Chemical compound CSCC[C@H](C(O)=O)NC(N)=O DEWDMTSMCKXBNP-SCSAIBSYSA-N 0.000 description 1
- JDXMIYHOSFNZKO-SCSAIBSYSA-N N-carbamoyl-D-valine Chemical compound CC(C)[C@H](C(O)=O)NC(N)=O JDXMIYHOSFNZKO-SCSAIBSYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 210000001822 immobilized cell Anatomy 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14110585A JPS62270A (ja) | 1985-06-27 | 1985-06-27 | 新規な微生物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14110585A JPS62270A (ja) | 1985-06-27 | 1985-06-27 | 新規な微生物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62270A JPS62270A (ja) | 1987-01-06 |
| JPH0439315B2 true JPH0439315B2 (enrdf_load_stackoverflow) | 1992-06-29 |
Family
ID=15284294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14110585A Granted JPS62270A (ja) | 1985-06-27 | 1985-06-27 | 新規な微生物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62270A (enrdf_load_stackoverflow) |
-
1985
- 1985-06-27 JP JP14110585A patent/JPS62270A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62270A (ja) | 1987-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |