JPH04221764A - 連続的貫流−分析装置及びこのような分析装置の運転方法 - Google Patents
連続的貫流−分析装置及びこのような分析装置の運転方法Info
- Publication number
- JPH04221764A JPH04221764A JP8202591A JP8202591A JPH04221764A JP H04221764 A JPH04221764 A JP H04221764A JP 8202591 A JP8202591 A JP 8202591A JP 8202591 A JP8202591 A JP 8202591A JP H04221764 A JPH04221764 A JP H04221764A
- Authority
- JP
- Japan
- Prior art keywords
- carrier medium
- capillary system
- analyte
- detector
- electrodes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011017 operating method Methods 0.000 title 1
- 230000005684 electric field Effects 0.000 claims abstract description 35
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 238000004458 analytical method Methods 0.000 claims description 53
- 239000012491 analyte Substances 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 19
- 238000004401 flow injection analysis Methods 0.000 claims description 18
- 239000003153 chemical reaction reagent Substances 0.000 claims description 15
- 238000002347 injection Methods 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 238000003860 storage Methods 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 6
- 238000011144 upstream manufacturing Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 5
- 239000008365 aqueous carrier Substances 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- 238000000206 photolithography Methods 0.000 claims description 3
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 229910021421 monocrystalline silicon Inorganic materials 0.000 claims description 2
- 229910021420 polycrystalline silicon Inorganic materials 0.000 claims description 2
- 238000012351 Integrated analysis Methods 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 238000005206 flow analysis Methods 0.000 claims 1
- 238000002798 spectrophotometry method Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 description 52
- 238000010586 diagram Methods 0.000 description 14
- 239000007788 liquid Substances 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 5
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 5
- 238000010276 construction Methods 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000035484 reaction time Effects 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000001139 pH measurement Methods 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
- G01N35/085—Flow Injection Analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N2030/285—Control of physical parameters of the fluid carrier electrically driven carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N2030/626—Detectors specially adapted therefor calibration, baseline
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/466—Flow patterns using more than one column with separation columns in parallel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
Landscapes
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Optical Measuring Cells (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH906/90-0 | 1990-03-20 | ||
| CH90690A CH679952A5 (cg-RX-API-DMAC10.html) | 1990-03-20 | 1990-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04221764A true JPH04221764A (ja) | 1992-08-12 |
Family
ID=4197932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8202591A Pending JPH04221764A (ja) | 1990-03-20 | 1991-03-20 | 連続的貫流−分析装置及びこのような分析装置の運転方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPH04221764A (cg-RX-API-DMAC10.html) |
| CH (1) | CH679952A5 (cg-RX-API-DMAC10.html) |
| DE (1) | DE4105107A1 (cg-RX-API-DMAC10.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480614A (en) * | 1993-03-16 | 1996-01-02 | Hitachi, Ltd. | Micro-reactor device for minute sample analysis |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69530669T2 (de) * | 1995-02-18 | 2003-11-27 | Agilent Technologies Deutschla | Vermischen von Flüssigkeiten mittels Elektroosmose |
| JP3361530B2 (ja) | 1996-06-28 | 2003-01-07 | カリパー・テクノロジーズ・コープ． | 電子ピペッタおよび電気泳動バイアスのための補償手段 |
| US5779868A (en) * | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
| US5869004A (en) * | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
| JP2003516211A (ja) * | 1999-12-08 | 2003-05-13 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Ｘ線吸収度を調整しうるフィルタ素子を有するフィルタとｘ線吸収センサとを具えるｘ線装置 |
| ATE340025T1 (de) | 2000-01-06 | 2006-10-15 | Caliper Life Sciences Inc | Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse |
| JP2003522328A (ja) * | 2000-02-04 | 2003-07-22 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 調節可能な吸収を有するフィルタ要素が備えられたフィルタを有するｘ線装置 |
| JP2003522329A (ja) * | 2000-02-04 | 2003-07-22 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 調節可能な吸収を有するフィルタ要素が備えられたフィルタを有するｘ線装置 |
| JP4184078B2 (ja) * | 2000-11-09 | 2008-11-19 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | マトリックスアドレッシングの手段により制御可能な流動体レベルを伴う多重の流動体要素 |
-
1990
- 1990-03-20 CH CH90690A patent/CH679952A5/de not_active IP Right Cessation
-
1991
- 1991-02-19 DE DE19914105107 patent/DE4105107A1/de not_active Withdrawn
- 1991-03-20 JP JP8202591A patent/JPH04221764A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480614A (en) * | 1993-03-16 | 1996-01-02 | Hitachi, Ltd. | Micro-reactor device for minute sample analysis |
Also Published As
| Publication number | Publication date |
|---|---|
| DE4105107A1 (de) | 1991-09-26 |
| CH679952A5 (cg-RX-API-DMAC10.html) | 1992-05-15 |
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