JPH0415165B2 - - Google Patents
Info
- Publication number
- JPH0415165B2 JPH0415165B2 JP26527084A JP26527084A JPH0415165B2 JP H0415165 B2 JPH0415165 B2 JP H0415165B2 JP 26527084 A JP26527084 A JP 26527084A JP 26527084 A JP26527084 A JP 26527084A JP H0415165 B2 JPH0415165 B2 JP H0415165B2
- Authority
- JP
- Japan
- Prior art keywords
- calcium
- phosphorus
- apatite
- water
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 37
- 229910052586 apatite Inorganic materials 0.000 claims description 36
- 239000002994 raw material Substances 0.000 claims description 29
- 239000000843 powder Substances 0.000 claims description 24
- 239000011575 calcium Substances 0.000 claims description 20
- 229910052698 phosphorus Inorganic materials 0.000 claims description 16
- 239000011574 phosphorus Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 11
- 239000001110 calcium chloride Substances 0.000 claims description 11
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 11
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 11
- 239000003960 organic solvent Substances 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 10
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 9
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 9
- -1 phosphorus alkoxide Chemical class 0.000 claims description 9
- ZQBZAOZWBKABNC-UHFFFAOYSA-N [P].[Ca] Chemical compound [P].[Ca] ZQBZAOZWBKABNC-UHFFFAOYSA-N 0.000 claims description 8
- 229910052791 calcium Inorganic materials 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- 235000019270 ammonium chloride Nutrition 0.000 claims description 5
- 229910001622 calcium bromide Inorganic materials 0.000 claims description 5
- 229940043430 calcium compound Drugs 0.000 claims description 5
- 150000001674 calcium compounds Chemical class 0.000 claims description 5
- WGEFECGEFUFIQW-UHFFFAOYSA-L calcium dibromide Chemical compound [Ca+2].[Br-].[Br-] WGEFECGEFUFIQW-UHFFFAOYSA-L 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000005979 thermal decomposition reaction Methods 0.000 claims description 5
- SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 claims description 4
- 239000012046 mixed solvent Substances 0.000 claims description 4
- 150000002894 organic compounds Chemical class 0.000 claims description 4
- 150000002903 organophosphorus compounds Chemical class 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- BDZBKCUKTQZUTL-UHFFFAOYSA-N triethyl phosphite Chemical compound CCOP(OCC)OCC BDZBKCUKTQZUTL-UHFFFAOYSA-N 0.000 claims 2
- 239000000243 solution Substances 0.000 description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- 239000000047 product Substances 0.000 description 20
- 238000002441 X-ray diffraction Methods 0.000 description 15
- 238000006243 chemical reaction Methods 0.000 description 15
- 229910052589 chlorapatite Inorganic materials 0.000 description 15
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 15
- 238000005118 spray pyrolysis Methods 0.000 description 11
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 10
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 10
- 235000011148 calcium chloride Nutrition 0.000 description 9
- 238000002156 mixing Methods 0.000 description 9
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 8
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 8
- 229910052794 bromium Inorganic materials 0.000 description 8
- YLOZVEBTKJNEIS-UHFFFAOYSA-L calcium;dihydrogen phosphate;chloride Chemical compound Cl.[Ca+2].OP([O-])([O-])=O YLOZVEBTKJNEIS-UHFFFAOYSA-L 0.000 description 8
- 239000012071 phase Substances 0.000 description 7
- 239000002244 precipitate Substances 0.000 description 7
- 238000001308 synthesis method Methods 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 239000000460 chlorine Substances 0.000 description 6
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000006104 solid solution Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000001027 hydrothermal synthesis Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229910001961 silver nitrate Inorganic materials 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- ICSSIKVYVJQJND-UHFFFAOYSA-N calcium nitrate tetrahydrate Chemical compound O.O.O.O.[Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ICSSIKVYVJQJND-UHFFFAOYSA-N 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000002485 combustion reaction Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229910017604 nitric acid Inorganic materials 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 229910004261 CaF 2 Inorganic materials 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003018 phosphorus compounds Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- ADZWSOLPGZMUMY-UHFFFAOYSA-M silver bromide Chemical compound [Ag]Br ADZWSOLPGZMUMY-UHFFFAOYSA-M 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003746 solid phase reaction Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Crystals, And After-Treatments Of Crystals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26527084A JPS61146704A (ja) | 1984-12-18 | 1984-12-18 | カルシウム−リン系アパタイトの製造方法 |
| US06/893,324 US4711769A (en) | 1984-12-18 | 1985-12-18 | Calcium-phosphorus-apatite having novel properties and process for preparing the same |
| EP86900255A EP0205622B1 (en) | 1984-12-18 | 1985-12-18 | Calcium-phosphorus type apatite having novel properties and process for its production |
| DE1986900255 DE205622T1 (de) | 1984-12-18 | 1985-12-18 | Apatit von kalzium-phosphor-typ mit neuen eigenschaften und herstellungsverfahren. |
| DE86900255T DE3587573T2 (de) | 1984-12-18 | 1985-12-18 | Apatit vom kalzium-phosphor-typ mit neuen eigenschaften und herstellungsverfahren. |
| PCT/JP1985/000693 WO1986003733A1 (en) | 1984-12-18 | 1985-12-18 | Calcium-phosphorus type apatite having novel properties and process for its production |
| US07/095,222 US4836994A (en) | 1984-12-18 | 1987-09-11 | Calcium-phosphorus-apatite having novel properties and process for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26527084A JPS61146704A (ja) | 1984-12-18 | 1984-12-18 | カルシウム−リン系アパタイトの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61146704A JPS61146704A (ja) | 1986-07-04 |
| JPH0415165B2 true JPH0415165B2 (enrdf_load_stackoverflow) | 1992-03-17 |
Family
ID=17414892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP26527084A Granted JPS61146704A (ja) | 1984-12-18 | 1984-12-18 | カルシウム−リン系アパタイトの製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61146704A (enrdf_load_stackoverflow) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH057217Y2 (enrdf_load_stackoverflow) * | 1986-03-13 | 1993-02-24 | ||
| JPH0774231B2 (ja) * | 1986-12-11 | 1995-08-09 | 東燃株式会社 | 抗体の分離方法 |
| JPH07106888B2 (ja) * | 1987-04-03 | 1995-11-15 | 積水化成品工業株式会社 | 塩素アパタイトの製造法 |
| US5205928A (en) * | 1988-03-11 | 1993-04-27 | Kanto Kagaku Kabushiki Kaisha | Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material comprising the microspherical sintered bodies of hydroxyapatite |
| EP1761459B1 (en) * | 2004-03-15 | 2017-02-01 | Eidgenössische Technische Hochschule Zürich | Flame synthesis of metal salt nanoparticles, in particular calcium and phosphate comprising nanoparticles |
-
1984
- 1984-12-18 JP JP26527084A patent/JPS61146704A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61146704A (ja) | 1986-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3587573T2 (de) | Apatit vom kalzium-phosphor-typ mit neuen eigenschaften und herstellungsverfahren. | |
| US4481175A (en) | Process for preparing apatite | |
| JP4540225B2 (ja) | マグネシウムおよびカーボネート置換ヒドロキシアパタイトの製造方法 | |
| JP2010100521A (ja) | 単相カーボネート置換ヒドロキシアパタイト組成物 | |
| Kizalaite et al. | Dissolution–precipitation synthesis and thermal stability of magnesium whitlockite | |
| US5141511A (en) | Resorptive bone ceramic on the basis of tricalcium phosphate | |
| JPS60239313A (ja) | 結晶質リン酸ジルコニウムの製造方法 | |
| JPH0415166B2 (enrdf_load_stackoverflow) | ||
| JPH0415165B2 (enrdf_load_stackoverflow) | ||
| JPS5913443B2 (ja) | ＣａＯ−Ｐ↓２Ｏ↓５系アパタイトの製造法 | |
| US4725369A (en) | Process for the preparation of substantially crystalline calcium sodium metaphosphate | |
| JPS62113709A (ja) | ヒドロキシアパタイトの製造方法 | |
| Tsuhako et al. | Preparation and Chemical Properties of a Novel Layered Cerium (IV) Phosphate. | |
| KOJIMA et al. | ADSORPTION OF GLYCINE ON AMORPHOUS CALCIUM PHOSPHATE AND ITS THERMAL STABILITY | |
| WO1998047814A1 (en) | Solution crystallization process for the production of incongruently-soluble acid phosphates by incorporating a phosphate salt solution wash | |
| Legrouri et al. | Preparation and thermal properties of a series of mixed calcium-cobalt phosphates | |
| JPH01264915A (ja) | フッ素アパタイトの製造方法 | |
| RU2180890C1 (ru) | Способ получения высококонденсированного полифосфата аммония | |
| Sopyan | Bone implant materials from eggshell waste | |
| JP2829048B2 (ja) | 難溶性半水セッコウ繊維の製造方法 | |
| US4997634A (en) | Preparation of medium density, fast-dissolving, tetrasodium pyrophosphate | |
| Alqap et al. | Thermal analysis on hydroxyapatite synthesis through mechanochemical method | |
| JPH0458406B2 (enrdf_load_stackoverflow) | ||
| JPH0425232B2 (enrdf_load_stackoverflow) | ||
| TOYAMA et al. | Mechanochemical synthesis of amorphous calcium phosphate from bovine bone |