JPH037669B2 - - Google Patents
Info
- Publication number
- JPH037669B2 JPH037669B2 JP62164871A JP16487187A JPH037669B2 JP H037669 B2 JPH037669 B2 JP H037669B2 JP 62164871 A JP62164871 A JP 62164871A JP 16487187 A JP16487187 A JP 16487187A JP H037669 B2 JPH037669 B2 JP H037669B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- salts
- reaction
- compound
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8028042 | 1980-08-29 | ||
| GB8028042 | 1980-08-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56134952A Division JPS5775989A (en) | 1980-08-29 | 1981-08-27 | Novel cephem compound, its salt, its preparation, and remedy and preventive for bacteriosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63107962A JPS63107962A (ja) | 1988-05-12 |
| JPH037669B2 true JPH037669B2 (en, 2012) | 1991-02-04 |
Family
ID=10515736
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56134952A Pending JPS5775989A (en) | 1980-08-29 | 1981-08-27 | Novel cephem compound, its salt, its preparation, and remedy and preventive for bacteriosis |
| JP62164871A Granted JPS63107962A (ja) | 1980-08-29 | 1987-06-30 | 酢酸誘導体およびその塩 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56134952A Pending JPS5775989A (en) | 1980-08-29 | 1981-08-27 | Novel cephem compound, its salt, its preparation, and remedy and preventive for bacteriosis |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4407798A (en, 2012) |
| EP (2) | EP0046964B1 (en, 2012) |
| JP (2) | JPS5775989A (en, 2012) |
| DE (1) | DE3175156D1 (en, 2012) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5859991A (ja) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | 新規セフェム化合物 |
| EP0137442A3 (de) * | 1983-10-08 | 1986-01-15 | Hoechst Aktiengesellschaft | Cephalosporinderivate und Verfahren zu ihrer Herstellung |
| EP0150609A3 (en) * | 1983-12-30 | 1986-04-23 | Glaxo Group Limited | Cephalosporin antibiotics |
| JPS60169486A (ja) * | 1984-02-10 | 1985-09-02 | Yamanouchi Pharmaceut Co Ltd | ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法 |
| DE3419014A1 (de) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 7-amino-3-(3-formamidopyridinium)methyl-3-cephem-4-carboxylat und verwendung zur synthese von ss-lactamantibiotika |
| SI3616695T1 (sl) | 2011-09-09 | 2025-01-31 | Merck Sharp & Dohme Llc | Ceftolozan/tazobaktam za zdravljenje intrapulmonalnih okužb |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| US20140274997A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Cephalosporin pharmaceutical compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| MX387913B (es) | 2013-03-15 | 2025-03-19 | Merck Sharp & Dohme Llc | Composiciones antibioticas de ceftolozano |
| EP3043797B1 (en) | 2013-09-09 | 2020-04-08 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
| US4079178A (en) * | 1971-05-14 | 1978-03-14 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position |
| US3932385A (en) * | 1971-05-14 | 1976-01-13 | Glaxo Laboratories Limited | Penicillins having a 6β-(α-etherified oximino) acylamido group |
| DE2760484C2 (en, 2012) * | 1976-04-14 | 1992-12-03 | Takeda Chemical Industries, Ltd., Osaka, Jp | |
| IT1192287B (it) * | 1977-11-14 | 1988-03-31 | Fujisawa Pharmaceutical Co | Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione |
| AR229883A1 (es) * | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato |
| ZA806977B (en) * | 1979-11-19 | 1981-10-28 | Fujisawa Pharmaceutical Co | 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
-
1981
- 1981-08-25 EP EP81106566A patent/EP0046964B1/en not_active Expired
- 1981-08-25 DE DE8181106566T patent/DE3175156D1/de not_active Expired
- 1981-08-25 EP EP85100916A patent/EP0156118A1/en not_active Withdrawn
- 1981-08-26 US US06/296,301 patent/US4407798A/en not_active Expired - Fee Related
- 1981-08-27 JP JP56134952A patent/JPS5775989A/ja active Pending
-
1987
- 1987-06-30 JP JP62164871A patent/JPS63107962A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5775989A (en) | 1982-05-12 |
| EP0046964A2 (en) | 1982-03-10 |
| US4407798A (en) | 1983-10-04 |
| EP0046964A3 (en) | 1983-02-16 |
| JPS63107962A (ja) | 1988-05-12 |
| EP0046964B1 (en) | 1986-08-20 |
| DE3175156D1 (en) | 1986-09-25 |
| EP0156118A1 (en) | 1985-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4883879A (en) | Cephalosporin compounds, processes for their preparation and antibacterial agents | |
| JPH0710870B2 (ja) | 新規セフェム化合物 | |
| JPH0215556B2 (en, 2012) | ||
| JPH037669B2 (en, 2012) | ||
| JPH0354111B2 (en, 2012) | ||
| CS238620B2 (en) | Production method of 3-pyridiniummethylderivatives of cefhalosporine | |
| JP2817203B2 (ja) | 新規セフェム化合物およびその製造法 | |
| EP0055466B1 (en) | Cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds | |
| JP2503476B2 (ja) | ３，７―ジ置換―３―セフェム化合物 | |
| JPH0121151B2 (en, 2012) | ||
| JPS58164594A (ja) | ７―アシルアミノ―３―セフェム―４―カルボン酸誘導体 | |
| JPH0262555B2 (en, 2012) | ||
| JPH0240679B2 (en, 2012) | ||
| US20050004094A1 (en) | Cephem compounds | |
| US4690921A (en) | Cephalosporin compounds and salts thereof | |
| US4988686A (en) | Cephem compounds and anti-bacterial agent | |
| JPS61178991A (ja) | 新規セフアロスポリン化合物 | |
| JPH0733777A (ja) | 新規セフェム化合物 | |
| JP2518546B2 (ja) | 新規セフェム化合物 | |
| JPS6236387A (ja) | ３，７−ジ置換−３−セフエム化合物およびその製法 | |
| JPH06135972A (ja) | 新規セフェム化合物 | |
| JPH027316B2 (en, 2012) | ||
| JPH0359076B2 (en, 2012) | ||
| JPH06509550A (ja) | 新規なセフェム化合物 | |
| JPH051271B2 (en, 2012) |