JPH0375541B2 - - Google Patents
Info
- Publication number
- JPH0375541B2 JPH0375541B2 JP1112745A JP11274589A JPH0375541B2 JP H0375541 B2 JPH0375541 B2 JP H0375541B2 JP 1112745 A JP1112745 A JP 1112745A JP 11274589 A JP11274589 A JP 11274589A JP H0375541 B2 JPH0375541 B2 JP H0375541B2
- Authority
- JP
- Japan
- Prior art keywords
- solution
- mixture
- acid
- toluene
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/122,599 US4301288A (en) | 1980-02-19 | 1980-02-19 | Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid |
| US06/122,470 US4301291A (en) | 1980-02-19 | 1980-02-19 | Intermediates for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid |
| US122657 | 1980-02-19 | ||
| US122599 | 1980-02-19 | ||
| US06/122,657 US4301289A (en) | 1980-02-19 | 1980-02-19 | Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid |
| US122470 | 1980-02-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2286781A Division JPS56131582A (en) | 1980-02-19 | 1981-02-18 | Manufacture of 6,7-dihydro-9-fluoro-5-methyl- 1-oxo-1h,5h-benzo(ij)quinolidine-2-carboxylic acid and intermediate therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0215066A JPH0215066A (ja) | 1990-01-18 |
| JPH0375541B2 true JPH0375541B2 (enrdf_load_stackoverflow) | 1991-12-02 |
Family
ID=27382802
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1112746A Granted JPH0215077A (ja) | 1980-02-19 | 1989-05-01 | フルメキンの製造方法 |
| JP1112745A Granted JPH0215066A (ja) | 1980-02-19 | 1989-05-01 | フルメキン製造用中間体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1112746A Granted JPH0215077A (ja) | 1980-02-19 | 1989-05-01 | フルメキンの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| JP (2) | JPH0215077A (enrdf_load_stackoverflow) |
| AU (1) | AU524459B2 (enrdf_load_stackoverflow) |
| FR (1) | FR2476079A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2069498B (enrdf_load_stackoverflow) |
| IE (1) | IE50928B1 (enrdf_load_stackoverflow) |
| NZ (1) | NZ196293A (enrdf_load_stackoverflow) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4400386A (en) * | 1981-11-06 | 1983-08-23 | Riker Laboratories, Inc. | Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine |
| US4472407A (en) * | 1983-03-17 | 1984-09-18 | Riker Laboratories, Inc. | Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu |
| DE3413693A1 (de) * | 1984-04-11 | 1985-10-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Fluorierte anilinderivate und ihre verwendung |
| IT1231425B (it) * | 1987-10-05 | 1991-12-04 | Prodotti Antibiotici Spa | Procedimento per la sintesi di un derivato dell'acido benzo (ij) chinolizin-2-carbossilico |
| CA2009664A1 (en) * | 1989-02-27 | 1990-08-27 | Philip Thiam Shin Lau | Tetrahydroquinolines and method of preparation |
| US5043469A (en) * | 1989-07-17 | 1991-08-27 | Eastman Kodak Company | Process for preparing 5-substituted aminophenols |
| WO2002022585A1 (fr) * | 2000-09-14 | 2002-03-21 | Kaken Pharmaceutical Co., Ltd. | Composes de tetrahydroquinoline |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE793524A (fr) * | 1971-12-30 | 1973-06-29 | Riker Laboratories Inc | Acides benzoquinolizine-carboxyliques et leurs derives |
| ZA728444B (en) * | 1971-12-30 | 1973-10-31 | Riker Laboratories Inc | Substituted benzo(ij)quinolizine-2-carboxylic acids and derivatives thereof |
-
1981
- 1981-02-18 FR FR8103180A patent/FR2476079A1/fr active Granted
- 1981-02-18 NZ NZ196293A patent/NZ196293A/xx unknown
- 1981-02-18 IE IE326/81A patent/IE50928B1/en not_active IP Right Cessation
- 1981-02-18 GB GB8105054A patent/GB2069498B/en not_active Expired
- 1981-02-18 AU AU67425/81A patent/AU524459B2/en not_active Ceased
-
1989
- 1989-05-01 JP JP1112746A patent/JPH0215077A/ja active Granted
- 1989-05-01 JP JP1112745A patent/JPH0215066A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2476079A1 (fr) | 1981-08-21 |
| JPH0416474B2 (enrdf_load_stackoverflow) | 1992-03-24 |
| GB2069498B (en) | 1984-02-08 |
| FR2476079B1 (enrdf_load_stackoverflow) | 1984-04-20 |
| JPH0215077A (ja) | 1990-01-18 |
| NZ196293A (en) | 1983-09-02 |
| AU6742581A (en) | 1981-09-24 |
| IE810326L (en) | 1981-08-19 |
| GB2069498A (en) | 1981-08-26 |
| JPH0215066A (ja) | 1990-01-18 |
| IE50928B1 (en) | 1986-08-20 |
| AU524459B2 (en) | 1982-09-16 |
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