JPH0367069B2 - - Google Patents
Info
- Publication number
- JPH0367069B2 JPH0367069B2 JP58053313A JP5331383A JPH0367069B2 JP H0367069 B2 JPH0367069 B2 JP H0367069B2 JP 58053313 A JP58053313 A JP 58053313A JP 5331383 A JP5331383 A JP 5331383A JP H0367069 B2 JPH0367069 B2 JP H0367069B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- hemin
- heme
- acetic acid
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004369 blood Anatomy 0.000 claims description 23
- 239000008280 blood Substances 0.000 claims description 23
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 claims description 20
- 229940025294 hemin Drugs 0.000 claims description 19
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 229910021529 ammonia Inorganic materials 0.000 claims description 4
- 229910001631 strontium chloride Inorganic materials 0.000 claims description 4
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims description 4
- 150000003973 alkyl amines Chemical class 0.000 claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 25
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
- 229960000583 acetic acid Drugs 0.000 description 11
- 150000003278 haem Chemical class 0.000 description 11
- 239000012362 glacial acetic acid Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- 238000000605 extraction Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 238000001816 cooling Methods 0.000 description 5
- 102000018146 globin Human genes 0.000 description 5
- 108060003196 globin Proteins 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 241000283690 Bos taurus Species 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000001694 spray drying Methods 0.000 description 3
- BMUDPLZKKRQECS-UHFFFAOYSA-K 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid iron(3+) hydroxide Chemical compound [OH-].[Fe+3].[N-]1C2=C(C)C(CCC(O)=O)=C1C=C([N-]1)C(CCC(O)=O)=C(C)C1=CC(C(C)=C1C=C)=NC1=CC(C(C)=C1C=C)=NC1=C2 BMUDPLZKKRQECS-UHFFFAOYSA-K 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229940109738 hematin Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 229950003776 protoporphyrin Drugs 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 239000005996 Blood meal Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229940043279 diisopropylamine Drugs 0.000 description 1
- GPRXGEKBQVXWAQ-UHFFFAOYSA-L disodium;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoate Chemical compound [Na+].[Na+].N1C(C=C2C(=C(C)C(=CC=3C(C)=C(CCC([O-])=O)C(N=3)=C3)N2)C=C)=C(C)C(C=C)=C1C=C1C(C)=C(CCC([O-])=O)C3=N1 GPRXGEKBQVXWAQ-UHFFFAOYSA-L 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 150000004698 iron complex Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 108020001775 protein parts Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58053313A JPS59181279A (ja) | 1983-03-29 | 1983-03-29 | ヘミンの製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58053313A JPS59181279A (ja) | 1983-03-29 | 1983-03-29 | ヘミンの製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59181279A JPS59181279A (ja) | 1984-10-15 |
| JPH0367069B2 true JPH0367069B2 (enrdf_load_stackoverflow) | 1991-10-21 |
Family
ID=12939227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58053313A Granted JPS59181279A (ja) | 1983-03-29 | 1983-03-29 | ヘミンの製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59181279A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102659791B (zh) * | 2012-04-12 | 2015-01-07 | 武汉普赛特膜技术循环利用有限公司 | 一种从禽畜血液中提取氯化血红素和珠蛋白肽的方法 |
-
1983
- 1983-03-29 JP JP58053313A patent/JPS59181279A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59181279A (ja) | 1984-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1021826C (zh) | 从植物原料中提取卡哈苡苷的方法 | |
| US5276138A (en) | Process for solubilizing animal hair | |
| JPH0310659A (ja) | 鉄高含有ヘム鉄及びその製造法 | |
| CN108866134B (zh) | 一种蚕蛹蛋白多肽螯合钙的制备方法 | |
| US3936375A (en) | Process for dewatering a proteinaceous, aqueous sludge and for removing and recovering precipitating agents from a precipitate containing proteinaceous substances | |
| JPH0322865B2 (enrdf_load_stackoverflow) | ||
| JPH04189833A (ja) | ケラチン有機溶媒液およびその製造法 | |
| EP0056025A1 (en) | HEMEN CONCENTRATE AND PROCESS FOR THE PREPARATION THEREOF. | |
| JPH0367069B2 (enrdf_load_stackoverflow) | ||
| CN105777567B (zh) | 一种复合氨基酸螯合钙的制备方法 | |
| GB2022584A (en) | Process for separating mixtures of 3- and 4-nitro-phthalicacid | |
| JPS6117600A (ja) | テトラピロ−ル化合物により着色された物質の脱色法 | |
| US2171320A (en) | Process of preparing extracts of spleen and liver | |
| JPH0515684B2 (enrdf_load_stackoverflow) | ||
| JPH0725877A (ja) | ヘミンとプロトポルフィリンジエステル及びプロトポルフィリンジナトリウム塩の製造法 | |
| CA2062787C (en) | Process for the purification of hemin, a novel hemin derivative and a process for its preparation | |
| US6486318B1 (en) | Single pot process for preparing metal picolinates from alpha picoline | |
| JPH0574583B2 (enrdf_load_stackoverflow) | ||
| AU642530B2 (en) | A process for treating animal hairs by means of solubilization | |
| US3308026A (en) | Process for the production and recovery of the kallikrein-inacti-vator from proteinaceous hormone wastes | |
| CN110183497A (zh) | 一种从动物血球中提纯氯化血红素的方法 | |
| JPS6147155A (ja) | アミノ酸の製造法 | |
| US3201382A (en) | Process for preparing a biochemically active polypeptide from sheep pituitary growthhormone | |
| JPH11180948A (ja) | Ｓ−（１，２− ジカルボキシエチル） グルタチオンの製造法 | |
| JPS61275224A (ja) | コラゲナ−ゼ阻害剤 |