JPH0349558B2 - - Google Patents

Info

Publication number

JPH0349558B2

JPH0349558B2 JP7432983A JP7432983A JPH0349558B2 JP H0349558 B2 JPH0349558 B2 JP H0349558B2 JP 7432983 A JP7432983 A JP 7432983A JP 7432983 A JP7432983 A JP 7432983A JP H0349558 B2 JPH0349558 B2 JP H0349558B2

Authority

JP

Japan

Prior art keywords

lysine

medium

present

peptone

strain

Prior art date

1983-04-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
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• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 16
• 238000004519 manufacturing process Methods 0.000 claims description 10
• 239000004472 Lysine Substances 0.000 claims description 9
• 235000019766 L-Lysine Nutrition 0.000 claims description 7
• 239000001888 Peptone Substances 0.000 claims description 5
• 108010080698 Peptones Proteins 0.000 claims description 5
• 235000019319 peptone Nutrition 0.000 claims description 5
• 238000012258 culturing Methods 0.000 claims description 4
• 239000003910 polypeptide antibiotic agent Substances 0.000 claims description 4
• 241000894006 Bacteria Species 0.000 claims description 3
• 241000223201 Metarhizium Species 0.000 claims description 3
• WBVFBXZGHGWBRE-RZOMMOEVSA-N (2r)-2-[[(2s)-6-amino-2-[[(2r)-5-amino-2-[[(2s,3r)-2-[[(2r)-5-amino-2-[[(2s,4s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)-4-hydroxypentanoyl]amino]pentanoyl]amino]-3-hydroxybutanoyl]amino]pentanoyl]amino]hexa Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](C[C@H](O)CN=C(N)N)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](CCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(O)=O)CC1=CC=C(O)C=C1 WBVFBXZGHGWBRE-RZOMMOEVSA-N 0.000 description 8
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
• VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 4
• LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
• 229910052757 nitrogen Inorganic materials 0.000 description 3
• PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
• 230000001580 bacterial effect Effects 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 239000008103 glucose Substances 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 235000018977 lysine Nutrition 0.000 description 2
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
• 235000019341 magnesium sulphate Nutrition 0.000 description 2
• 238000000034 method Methods 0.000 description 2
• 239000001103 potassium chloride Substances 0.000 description 2
• 235000011164 potassium chloride Nutrition 0.000 description 2
• 229910000160 potassium phosphate Inorganic materials 0.000 description 2
• 235000011009 potassium phosphates Nutrition 0.000 description 2
• 235000010344 sodium nitrate Nutrition 0.000 description 2
• 239000004317 sodium nitrate Substances 0.000 description 2
• CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 241000223250 Metarhizium anisopliae Species 0.000 description 1
• 208000036142 Viral infection Diseases 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 238000005273 aeration Methods 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 230000005907 cancer growth Effects 0.000 description 1
• 239000000306 component Substances 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• 239000012533 medium component Substances 0.000 description 1
• 230000009385 viral infection Effects 0.000 description 1