JPH03291208A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having high moisture-retention and effective in suppressing tyrosinase action by compounding an extract separated from the internal organs of a gastropode such as abalone, wreath shell and seahare or the above extract treated with a proteinase. CONSTITUTION:The objective cosmetic can be produced by compounding an extract separated from the internal organs of a gastropode such as abalone, wreath shell, seahare and slug or the extract treated with a proteinase such as trypsin and pepsin. It exhibits excellent moisture-retention effect, melanogenesis-suppressing action caused by tyrosinase-suppressing action and a lipid peroxide generation-suppressing action caused by its antioxidation action to human skin. The body warmth can be maintained during or after bathing by adding the cosmetic to bath water. It can be suitably used as makeup cosmetic, hair cosmetic, bathing agent, etc., in addition to foundation cosmetic.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to cosmetics. More specifically, the present invention relates to cosmetics that can be suitably used in basic cosmetics, make-up cosmetics, hair cosmetics, bath additives, and the like.

[Conventional technology] Conventionally, it has been used to provide excellent moisturizing and emollient effects to the skin, inhibiting tyrosinase activity and lipid peroxide production, and has comprehensive effects such as moisturizing, whitening, and anti-aging effects. The development of cosmetics that exhibit unique cosmetic effects is eagerly awaited.

Therefore, as a cosmetic that is easily absorbed through the skin and activates skin metabolism by supplying physiologically active substances to the skin, JP-A-59-IIOEOS and JP-A-5
A cosmetic described in Japanese Patent No. 9-95210 has been proposed.

However, although the cosmetics described in these publications do indeed have the effect of activating skin metabolism, they suppress tyrosinase activity, suppress the production of lipid peroxide, and have a moisturizing effect. However, it does not sufficiently exhibit the whitening effect and anti-aging effect at the same time.

[Problems to be Solved by the Invention] In view of the above-mentioned prior art, the present inventors have provided the skin with excellent moisturizing and emollient effects that are effective against age spots and freckles, suppressing the activity of tyrosinase and reducing peroxidation. As a result of extensive research aimed at producing cosmetics that simultaneously inhibit lipid production and exhibit moisturizing, whitening, and anti-aging effects, we unexpectedly discovered that an extract obtained from the internal organs of gastropods... We have now completed the present invention by discovering that all of these effects are exhibited simultaneously, and that this extract also exhibits a hair-protecting effect and a heat-retaining effect as a bath additive.

[Means for Solving the Problems] That is, the present invention relates to a cosmetic containing an extract obtained from the internal organs of gastropods.

[Operations and Examples] The components of the extract obtained from the internal organs of gastropods used in the present invention are not yet clear, but according to the research of the present inventors, various amino acids and a few It has been confirmed that it contains sugars and polysaccharides. and,
It is believed that these various ingredients exert the cosmetic effects aimed at in the present invention.

Examples of gastropods used in the present invention include abalone,
Turban shell, tokobushi, turban shell, tamakibi, conch shell,
Examples include Aplysia, lamina, snails, snails, slugs, etc., but the present invention is not limited to these examples. Furthermore, among these gastropods,
Abalone, turban shell, and Aplysia are particularly preferable because the yield of internal organs in terms of individual weight is relatively high.

Extracts obtained from internal organs of gastropods used in the present invention include, for example, extracts obtained by immersing fresh gastropods or freshly frozen internal organs of gastropods in an extraction solvent and extracting them. liquid, a concentrated extract obtained by concentrating the extract, powder obtained by freeze-drying or spray-drying the extract, granules, particulates, etc., and the present invention is not limited by the form of such extract. It's not something you can do.

There are various methods for preparing the extract, but one example is to cut the internal organs of a gastropod into small pieces, immerse them in the extraction solvent described below, and then heat them. Although the present invention is not limited to such a method, the present invention is not limited to such a method.

Examples of the extraction solvent include water:methanol,
Lower alcohols such as ethanol: Polyols such as ethylene glycol, propylene glycol, glycerin, and 1,3-butylene glycol; Higher alcohols such as oleyl alcohol, stearyl alcohol, and octyldodecanol; Ketones such as acetone: Ethyl acetate and hydrocarbon solvents such as hexane, dichloromethane, benzene, toluene, and ethers, and these may be used alone or in combination of two or more. Among these, water or water-soluble solvents are preferred from the viewpoint of wide application to cosmetics, and water, ethanol, glycerin, and 1,3-butylene glycol are particularly preferred.

In this study, during extraction, for example, proteolytic enzymes such as trypsin, pepsin, actinase, glycolglycine bebutitase, carboxybeptidase, aminopebutitase, papain, promelain, chymopapain, and chymotrypsin were used. Treatment of the extract further suppresses tyrosinase activity, 1; II
L, and is preferable because it exhibits the effect of suppressing the production of lipid peroxide. The amount of the protease used is preferably 0.01 to 10 parts, preferably <0.1 to 1 part, based on 100 parts (parts by weight, hereinafter the same) of the internal organs of the gastropod. If the amount used is less than the above range, protein decomposition may be insufficient and the effects of the extract will tend to decrease; if the amount exceeds the above range, adding more than the necessary amount It makes no sense considering the characteristics of the enzyme.

The extraction time varies depending on the type of solvent and extraction temperature, so it cannot be determined generally, but it is usually between 1 and 48
time, preferably 3 to 12 hours. In addition, since the extraction temperature varies depending on the type of solvent, etc., it cannot be determined generally, but it should be 0°C or higher, and usually 30°C or higher.
A suitable temperature is 70°C.

In addition, the pH of the obtained extract was adjusted to ensure safety for the skin.
is preferably adjusted to about 4 to 8.

The extract obtained in this way has an excellent moisturizing effect on human skin, an effect of suppressing melanin production by suppressing tyrosinase activity, and a suppressing effect of lipid peroxide production by antioxidant effect, and furthermore, when added to hot water, It has an excellent ability to maintain body temperature during and after bathing.

The cosmetic of the present invention contains the above-mentioned extract. The amount of the extract to be incorporated into cosmetics cannot be determined unconditionally as it varies depending on the type of cosmetics, etc.
For example, the solid content of the extract is 0.05 to 90 parts per 100 parts of the cosmetic, preferably o, i to
Preferably 10 parts. If the blending amount is less than the above-mentioned range, the effect of blending the extract tends to be reduced, and if it exceeds the above-mentioned range, no further improvement in the effect can be expected.

The form of the cosmetic of the present invention is arbitrary, and includes, for example, a cream, a milky lotion, a lotion, a solid cosmetic, and the like.

Further, as mentioned above, the extract has an excellent effect of retaining body temperature when added to hot water, so the cosmetic composition of the present invention can be suitably used as a bath agent. When the cosmetic of the present invention is used as a bath additive, the amount of the extract added to the cosmetic is 0.1 to 90 parts in terms of solid content of the extract per 100 parts of the cosmetic. , preferably 0
．． It is desirable to use 1-10 parts. When using the bath agent, the amount of the solvent used is preferably adjusted to about 5 to 25 g per 200 g of normal hot water.

The cosmetic of the present invention contains the above-mentioned extract, but in addition to the extract, it also contains, for example, excipients and fragrances commonly used in cosmetics, oils and fats, surfactants, and moisturizers. Various cosmetic ingredients such as a pH 1) regulator, a thickener, a preservative, an antioxidant, and an ultraviolet absorber are appropriately blended.

Examples of the oils and fats include paraffin, cetanol, avocado oil, olive oil, etc., which are commonly used in cosmetics.
Vegetable oils such as jojoba oil and coconut oil; beef tallow, pork tallow, horse tallow,
Examples include animal fats such as Termolura, mink oil, and parcellin oil; synthetic oils and fats such as tricaprylcapric acid glycerin, trioctanoic acid glycerin, triisopalmitic acid glycerin, and silicone oil.

Examples of the surfactant include anionic surfactants such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and jetanolamide laurate; cationic surfactants such as stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, and benzalkonium chloride; Nonionic surfactants such as glyceryl monostearate, sorbitan monostearate, polyoxyethylene hydrogenated castor oil, sucrose ester, fatty acid amide, etc.

Examples of the moisturizing agent include synthetic moisturizing agents such as glycerin, propylene glycol, 1,3-butylene glycol, and sodium pyrrolidone carboxylate; hyaluronic acid, kolaken, elastin, placenta extract, royal jelly,
Examples include natural moisturizing liquids such as microbial fermentation liquid.

The amount of each of these cosmetic ingredients varies depending on the intended use of the cosmetic, and therefore cannot be determined generally, and is preferably adjusted as appropriate depending on the intended use.

The thus obtained cosmetic of the present invention moisturizes the skin,
It has the property of preventing spots, freckles, wrinkles, etc. and preventing skin aging, so it is used in basic cosmetics such as creams, emulsions, lotions, facial cleansers, packs, lipsticks, foundations, etc. It is prepared and used in the form of make-up cosmetics, body wash, toiletry products such as soap, bath salts, etc.

In addition, the cosmetics of the present invention are effective for preventing split ends and hair breakage and protecting the hair by improving the environment around the hair roots and acting directly on the hair. It can be appropriately prepared into hair products such as liquid, hair blowing agent, hair setting lotion, and hair cream, and hair toiletry products such as shampoo conditioner and hair treatment. Furthermore, the cosmetic composition of the present invention can also be suitably used as a bath agent, as mentioned above.

Next, the cosmetics of the present invention will be explained in more detail based on Examples, but the present invention is not limited to the Examples.

Preparation Example 1 (Manufacture of turban shell viscera extract) 5 kg of the viscera of a fresh turban shell, excluding the shell and muscle, was cut into small pieces, and then immersed in 3 g of an aqueous sodium citrate solution adjusted to be slightly alkaline. Next, 25 g of trypsin as a proteolytic enzyme was added to this aqueous solution and extracted for about 5 hours while heating to 55°C. After that, a 10-6 lactic acid aqueous solution was added to adjust the pH to 7.0, and filtration and purification were performed. About 2 kg of a light brown extract (solid content: about 5% by weight) was obtained.

Preparation Example 2 (Production of visceral extract of tokobushi) A light brown extract was prepared in the same manner as in Preparation Example 1, except that 5 kg of the viscera of fresh tokobushi, with the shell and muscle parts removed, was used instead of 5 kg of the viscera of turban shell. Approximately 2k (solid content approximately 5% by weight)
I got g.

Preparation Example 3 (Manufacture of Aplysia viscera extract) Light brown extraction was carried out in the same manner as in Preparation Example 1, except that 1 kg of fresh Aplysia viscera, with the shell and muscle parts removed, was used instead of 5 kg of turban shell viscera. About 2 fins (solid content about 5% by weight) were obtained.

Preparation Example 4 (Manufacture of abalone viscera extract) After removing the shell and muscle parts from fresh abalone, 5 kg of the viscera was cut into small pieces, and then immersed in 3 g of a weakly alkaline aqueous solution containing 0% 1,3-butylene glycol. 15 g of trypsin as a proteolytic enzyme was added to the aqueous solution, heated to 60°C and extracted for about 5 hours, and then an aqueous solution of IO9ci phosphoric acid was added to adjust pi to 8.0, and filtered. Purified light brown extract (solid content approximately 5% by weight) approximately 2k
I got g.

Preparation Example 5 (Production of visceral extract of ramus slug) A pale brown visceral extract was prepared in the same manner as in Preparation Example 4, except that 1 kg of fresh ramus viscera, with the muscle part removed, was used instead of 5 kg of abalone viscera. Approximately 2 kg of extract (solid content: approximately 5 weight, 9°) was obtained.

Preparation Example 6 (Manufacture of visceral extract of snail snail) Extract a light brown color in the same manner as in Preparation Example 4 using 1 kg of fresh snail viscera with the muscle part removed instead of 5 kg of abalone viscera. Approximately 2 kg of solids (solid content: approximately 5% by weight) was obtained.

Tone! ! Example 2 Example 7 (Production of visceral extract of turban shell) A light brown extract (solid content: approximately 5 weight 96) was prepared in the same manner as in Preparation Example 1 except that no protease was used.
I gained kg.

Preparation Example 8 (Manufacture of Tokobushi viscera extract) A light brown extract (solid content: about 5 weight 96) was prepared in the same manner as Preparation Example 2 except that no protease was used.
I got g.

Preparation Example 9 (Production of Aplysia Visceral Extract) In Preparation Example 3, a light brown extract (solid content of about 5% by weight) was prepared in the same manner as Preparation Example 2 except that no protease was used. I got it.

Preparation Example 10 (Production of abalone viscera extract) In the same manner as in Preparation Example 4 except that the protease was used, a light brown extract (solid content of about 5% by weight) was prepared in the same manner as in Preparation Example 4. I got it.

Preparation Example 11 (Production of visceral extract of Rami slug) A light brown extract (solid content: about 5% by weight) of about 2k was prepared in the same manner as in Preparation Example 5, except that no protease was used.
I got g.

Preparation Example 12 (Production of snail viscera extract) A light brown extract (solid content: about 5 weight, 9 o) was prepared in the same manner as in Preparation Example 6, except that no protease was used.
I gained kg.

Reference Examples 1 to 13 The following tests were conducted using the extracts obtained in Preparation Examples 1 to 12 as samples.

0) Tyrosinase activity inhibition effect (tyrosinase reaction method) Tyrosinase (2200 units) 1. OB was accurately weighed and dissolved in 2.0 ml of phosphate buffer (pH 6, 8) to prepare a tyrosinase solution.

Next, 0.8 ml of an aqueous solution obtained by diluting the viscera extract obtained in each preparation example 10 times was weighed accurately, and 0.05
% L-tyrosine solution and 1.0 ml of phosphate buffer (p
1.0 ml of H6,8) was added and thoroughly stirred to mix. 0.2 ml of the above tyrosinase solution was added to this solution and mixed by thorough stirring. The absorbance of this solution at a wavelength of 475 n- was immediately measured, and then placed in a constant temperature bath at 37°C.

After 24 minutes had elapsed, this solution was taken out from the thermostatic bath, the absorbance at a wavelength of 475 nm was measured again, and the tyrosinase activity index was determined from the following formula. In addition, a blank was obtained by performing the same operation using water instead of the extract. The results are shown in Table 1.

[Tyrosinase activity index] (In the formula, 24 is the absorbance of the solution to which the extract was added 24 minutes after the start of the test, and B24 is the absorbance of the solution 24 minutes after the start of the test.
The absorbance of the solution in which water was added instead of the extract after a minute has elapsed, To is the absorbance of the solution in which the extract was added immediately after the start of the test, and Bo is the absorbance of the solution in which water was added instead of the extract immediately after the start of the test. Indicates the absorbance of the solution. ) ■ Lipid peroxide production inhibitory effect (rodan/iron) 0.5M linoleic acid ethanol 1.0ml, 0.2M phosphate buffer (pH 7.0) fowl and ethanol 9.0
Each ml was accurately weighed and mixed well in an Erlenmeyer flask with a stopper. Add 50% of the extract solution weighed accurately to this solution.
% aqueous solution was added thereto, and the mixture was thoroughly shaken. Accurately weigh 0.1 ml of each of the solution immediately after preparation and the solution that had been left in a constant temperature bath at 40°C for 7 days.
Add 4.7 ml of 5% ethanol, 0.1 ml of 30% ammonium thiocyanate solution, and 0.1 ml of 2XlO-2M 3,596 hydrochloric acid solution of ferrous chloride, mix thoroughly, and after exactly 3 minutes have elapsed. wavelength of 500n
The absorbance at i was measured, and the peroxide value index was determined from the following formula. In addition, a blank was obtained by performing the same operation using water instead of the extract. The results are shown in Table 1.

[Peroxide price index CO' -TOX 100 (!Jci) B 7 B
.

(In the formula, T7 is the absorbance of the extract or the solution added after 7 days from the start of the test, B7 is the absorbance of the solution without the extract added after 7 days from the start of the test, and To is the absorbance of the solution after 7 days from the start of the test. Absorbance of the solution immediately after adding the extract, Bo
indicates the absorbance of a solution in which water was added instead of the extract immediately after the start of the test. ) Prescription example 1 [Cream] [Component (A)] (Part) Liquid paraffin 9.0 Paraffin
5.0 cetanol
2.0 Glyceryl Monostearate
2.0 Polyoxyethylene sorbitan monostearate 5.0 Butylparaben 0.1 [Component (B)] Extract obtained in Preparation Example 1 30.0 Glycerin 5.0 Carboxymethylcellulose 0.1 Methylparaben
0.1 Purified water 41.4 [
(C) Ingredient] Fragrance
0,3 After heating the above (A) component and (B) component to 80"C or higher, the (A) component and (B) component
The ingredients were mixed and stirred. After cooling this to 5o''C, the above component (C) was added and further stirred and mixed to prepare a uniform ream.

Prescription example 2 [Lotion] [Ingredients (Part) Ethanol 1090 Glycerin
3.01.3-Butylene glycol
2.0 Methylparaben 0
．． 2 Citric acid 0.1 Sodium citrate 0.3 Carboxyvinyl polymer 0.1 Extract obtained in Preparation Example 2
50,0 fragrance
Micro-purified water, the entire amount is io
A homogeneous lotion was prepared by mixing the above components in amounts of o and o parts.

Formulation example 3 [Back] [Ingredients] (Part) Polyvinyl alcohol 15.0 Hydroxymethyl cellulose 50 Propylene glycol
5.0 ethanol 7nol 10.0
Methylbellaben 0.1 Extract obtained from Preparation Example 3 10.0 Flavor
micro purified water
A uniform bag was prepared by mixing and stirring the above-mentioned ingredients in a total amount of 10 parts.

Formulation Example 4 [Preparation Example 4] The extract obtained in Preparation Example 4 is freeze-dried by removing water with a freeze-dried powder, and this is ground by a ball mill to obtain a powder (particle size of about 30 μm or less). was used.

[Collected amount] (part) red iron 0.5 yam oxidized scissors
15 black iron oxide
0.1 Chi oxide 72 10.0
Nylon powder 4.0 Sericite 28.0 Mica
23. .

Talc 25.0 Preparation Example 4
Freeze-dried powder of the resulting extract 0.7 [Old) Ingredients] Squalane 1.0 Methylpolysiloxane 4゜Propylparaben
o1 dehydroacetic acid
0.1 liquid paraffin 2° fragrance
Coarse
After mixing and stirring a small amount of the above CA, component) and component (B), and mixing the component (A) and component (B), the mixture was passed through a 200 Menoshini Tyler mesh sieve and pressed into a mold to form a uniform press. A powder was prepared.

Formulation Example 5 [Shampoo] The extract obtained in Preparation Example 3 was freeze-dried in the same manner as in Formulation Example 4, and the resulting powder (particle size of about 30 mm or less) was used.

[11i, min] (Part) Lauryl sulfate triethanolamine 15.0 Lauric acid diethanolamide
5.0 Methylparaben
0.1 propylparaben
0.1 Freeze-dried powder of the extract obtained in Preparation Example 3 0.5 Flavor
micro purified water
A uniform shampoo was prepared by mixing and stirring the above ingredients in amounts such that the total amount was 100.0 parts.

Formulation Example 6 [Hair Set Lotion] A powder (particle size of 100- or less) obtained by drying the extract obtained in Example 2 of 31B by spray drying was used.

[Ingredients] (Part) Gum tragacanth 2.0 Glycerin
1.0 ethanol
20.0 Methylparaben 0.2 Freeze-dried powder of the extract obtained in Preparation Example 2 0.5 Flavor
micro purified water
The above ingredients were mixed and stirred in such amounts that the total amount was 100.0 parts to obtain a uniform hair setting lotion.

Formulation Example 7 [Hair Rinse] The extract obtained in Preparation Example 1 was freeze-dried in the same manner as in Formulation Example 6, and ground to obtain a powder (particle size of about 30 microns or less), and this powder was used.

[Component (A)] (Part) Behenyl alcohol 0.2 cetanol
1.5 Stearyltrimethylammonium chloride 20 Glyceryl monostearate (self-emulsifying type) 2° Hexalan (manufactured by Kyoei Chemical Industry Co., Ltd.) 1.0 Freeze-dried powder of the extract obtained in Preparation Example 1 i, 0 [(B) Ingredients: Cohydroquine ethylcellulose 1.0 Methylparaben 0.2 Glycerin
3゜Purified water 8
7.9 (0 ingredients fragrance)
-0.2 The above (A) component and (B) component were each heated to 80° C. or higher, and then mixed and stirred. After cooling to 50'C, component (C) was added and further stirred and mixed to prepare a uniform hair rinse.

Formulation Example 8 [Bath Salt] The extract obtained in Preparation Example 3 was freeze-dried in the same manner as in Formulation Example 6, and a powder obtained by pulverization (particle size: 100-
(below) was used.

[Ingredients] (Part) Sodium sulfate 47.0 Sodium hydrogen carbonate
47.0 Preparation Example 3 Freeze-dried powder of the obtained extract 6.0 Flavor
A uniform bath agent was prepared by mixing and stirring trace amounts of the above components.

Comparative Formulation Example 1 A cream was prepared in the same manner as Formulation Example 1 except that purified water was used instead of the extract obtained in Preparation Example 1.

Comparative Prescription Example 2 A lotion was prepared in the same manner as Preparation Example 2 except that 'fi'i water was used instead of the extract obtained in Preparation Example 2.

Comparative Formulation Example 3 A bag was prepared in the same manner as Formulation Example 3 except that purified water was used instead of the extract obtained in Preparation Example 3.

Comparative Formulation Example 4 A shampoo was prepared in the same manner as Formulation Example 5, except that purified water was used instead of the extract obtained in Preparation Example 3.

Comparative Formulation Example 5 A hair setting lotion was prepared in the same manner as Formulation Example 6 except that purified water was used instead of the extract obtained in Preparation Example 2.

Comparative Formulation Example 6 A hair rinse was prepared in the same manner as Formulation Example 7 except that purified water was used instead of the extract obtained in Preparation Example 1.

Comparative Formulation Example 7 A bath agent was prepared in the same manner as Formulation Example 8 except that purified water was used instead of the extract obtained in Preparation Example 3.

Example 1 The following monitor tests were conducted on the cosmetics obtained in Formulation Examples 1 to 3 and Comparative Formulation Examples 1 to 3. The results are shown in Table 2.

(Monitor test) The moisturizing effect, emollient effect, and skin luster when each cosmetic was applied to the skin of the face and cheeks were evaluated according to the following criteria for 100 randomly selected women aged 18 to 55. Based on this, we conducted an evaluation.

[Moisture effect A: Very moist B: Somehow moist C: Average or not very moist E: No moist feeling at all [Emollient effect] A: Very soft and pleasant to the touch Good B: Somehow soft and has a good feel C: Average D: Doesn't feel very flexible and has a good feel E: Doesn't feel flexible at all and has a good feel [skin smoothness] A: Very shiny B: Somehow became shiny C: No change D Somehow lost luster E: Obviously lost luster Furthermore, as a result of the monitor test, no one complained of any skin abnormality.

[Blank below] Example 2 The hair cosmetics obtained in Formulation Examples 5 to 7 and Comparative Formulation Examples 4 to 6 were subjected to the following half-head test. The results are shown in Table 3.

(Half-head test) 20 randomly selected men between the ages of 18 and 60 used each hair cosmetic twice a day for 30 days. Kushidori was evaluated based on the following criteria.

[Shininess] A: Very shiny B: Somehow shiny C: No change D: Somehow lost gloss E: No shiny at all [Moist G] A: Very moist It feels better B: It feels moister and better C: There is no change D2 It doesn't feel moist at all E: It doesn't feel moist at all B: Somewhat improved C: No change D: Somewhat worse E: Completely worse In addition, as a result of the half-head test, no one complained of any abnormalities with their hair or scalp.

[Left below] Example 3 The following monitor tests were conducted on the bath additives obtained in Formulation Example 8 and Comparative Formulation Example 7. The results are shown in Table 4.

(Monitor test) 20 randomly selected women aged 30 to 60 were tested in a room at 20°C and 65% humidity after bathing when 25g of each bath additive was used per 20ON of hot water. The effectiveness of keeping body temperature after a 15-minute rest was evaluated based on the following criteria.

(Heat retention effect) A: Feels very warm B: Feels pleasantly warm C: Average D = Feels slightly chilly E: Chilly However, as a result of the monitor test, no one complained of any skin abnormalities. .

No. 4 table be effective.

Furthermore, when the cosmetic of the present invention is used as a bath agent, it has an excellent effect of keeping body temperature during and after bathing.

Furthermore, when the cosmetic of the present invention is used as a hair cosmetic, it exhibits effects such as preventing split ends and hair breakage and protecting the hair.

[Effect of the invention]

Claims (1)

[Claims] 1. A cosmetic containing an extract obtained from the internal organs of gastropods. 2. The cosmetic according to claim 1, wherein the extract has been treated with a proteolytic enzyme.