JPH0328404B2 - - Google Patents
Info
- Publication number
- JPH0328404B2 JPH0328404B2 JP56177323A JP17732381A JPH0328404B2 JP H0328404 B2 JPH0328404 B2 JP H0328404B2 JP 56177323 A JP56177323 A JP 56177323A JP 17732381 A JP17732381 A JP 17732381A JP H0328404 B2 JPH0328404 B2 JP H0328404B2
- Authority
- JP
- Japan
- Prior art keywords
- nifedipine
- formulation
- solid solution
- preparation
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 claims description 80
- 239000006104 solid solution Substances 0.000 claims description 61
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 58
- 229960001597 nifedipine Drugs 0.000 claims description 58
- 238000002360 preparation method Methods 0.000 claims description 46
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 32
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 32
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 29
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 29
- 239000010419 fine particle Substances 0.000 claims description 19
- 238000000576 coating method Methods 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- 239000011248 coating agent Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000004503 fine granule Substances 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 229920000609 methyl cellulose Polymers 0.000 claims description 5
- 239000001923 methylcellulose Substances 0.000 claims description 5
- 235000010981 methylcellulose Nutrition 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000003232 water-soluble binding agent Substances 0.000 claims description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 235000001727 glucose Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 77
- 230000000052 comparative effect Effects 0.000 description 29
- 238000004090 dissolution Methods 0.000 description 16
- 239000000843 powder Substances 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000005469 granulation Methods 0.000 description 7
- 230000003179 granulation Effects 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 238000007922 dissolution test Methods 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 239000003960 organic solvent Substances 0.000 description 5
- 206010002383 Angina Pectoris Diseases 0.000 description 4
- FHHZOYXKOICLGH-UHFFFAOYSA-N dichloromethane;ethanol Chemical compound CCO.ClCCl FHHZOYXKOICLGH-UHFFFAOYSA-N 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 235000021189 garnishes Nutrition 0.000 description 2
- 229940031702 hydroxypropyl methylcellulose 2208 Drugs 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009506 drug dissolution testing Methods 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17732381A JPS5877811A (ja) | 1981-11-04 | 1981-11-04 | 安定な易吸収性ニフエジピン製剤の製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17732381A JPS5877811A (ja) | 1981-11-04 | 1981-11-04 | 安定な易吸収性ニフエジピン製剤の製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5877811A JPS5877811A (ja) | 1983-05-11 |
| JPH0328404B2 true JPH0328404B2 (ko) | 1991-04-19 |
Family
ID=16028964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17732381A Granted JPS5877811A (ja) | 1981-11-04 | 1981-11-04 | 安定な易吸収性ニフエジピン製剤の製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5877811A (ko) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7432392B2 (en) | 2003-08-29 | 2008-10-07 | Japan Tobacco Inc. | Ester derivatives and medical use thereof |
| WO2010137888A2 (ko) | 2009-05-27 | 2010-12-02 | 주식회사 삼양사 | 생체이용률이 향상된 난용성 약물 함유 미립구 및 그 제조 방법 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3318649A1 (de) * | 1983-05-21 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | Zweiphasenformulierung |
| JPS6038322A (ja) * | 1983-08-11 | 1985-02-27 | Fujisawa Pharmaceut Co Ltd | ジヒドロピリジンａ物質含有易溶性固形製剤 |
| SE457326B (sv) * | 1986-02-14 | 1988-12-19 | Lejus Medical Ab | Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa |
| CA2328085C (en) | 1998-04-10 | 2006-08-22 | Mitsubishi Chemical Corporation | Solid dispersion containing sialic acid derivative |
| JP2002138034A (ja) * | 2000-10-27 | 2002-05-14 | Kyoto Pharmaceutical Industries Ltd | 苦味マスキングチュアブル錠およびその製造方法 |
| JP4644397B2 (ja) | 2001-09-05 | 2011-03-02 | 信越化学工業株式会社 | 難溶性薬物を含む医薬用固形製剤の製造方法 |
| JP6838446B2 (ja) * | 2017-03-22 | 2021-03-03 | ニプロ株式会社 | トルバプタン製剤およびその製造方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS542316A (en) * | 1977-06-07 | 1979-01-09 | Yamanouchi Pharmaceut Co Ltd | Solid pharmaceutical composition containing nifedipene |
-
1981
- 1981-11-04 JP JP17732381A patent/JPS5877811A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS542316A (en) * | 1977-06-07 | 1979-01-09 | Yamanouchi Pharmaceut Co Ltd | Solid pharmaceutical composition containing nifedipene |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7432392B2 (en) | 2003-08-29 | 2008-10-07 | Japan Tobacco Inc. | Ester derivatives and medical use thereof |
| WO2010137888A2 (ko) | 2009-05-27 | 2010-12-02 | 주식회사 삼양사 | 생체이용률이 향상된 난용성 약물 함유 미립구 및 그 제조 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5877811A (ja) | 1983-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1255223A (en) | Pellet formulation | |
| US8563042B2 (en) | Pharmaceutical composition containing fenofibrate and method for the preparation thereof | |
| EP1010423B1 (en) | Oral pharmaceutical preparation comprising an antiulcer benzimidazole derivative, and process for its production | |
| JPH0122245B2 (ko) | ||
| JP2001511156A (ja) | 高いバイオアベイラビリティーを有するフェノフィブレート医薬組成物及びそれを調製するための方法 | |
| HU196304B (en) | Process for production of granulates of medical active substances with delaying effect | |
| HU193359B (en) | Process for preparing a delayed theophylline composition | |
| KR0133526B1 (ko) | Nb-818의 용이흡수성 약제 | |
| TWI243063B (en) | Orally administrable nifedipine pellet and process for the preparation thereof | |
| JPH0328404B2 (ko) | ||
| EP1267840B1 (en) | Granulated particles with masked taste | |
| JPH031288B2 (ko) | ||
| US20020172727A1 (en) | Multiparticulate formulations of lithium salts for oral administration suitable for once-a-day administration | |
| KR20060020681A (ko) | 염산 베니디핀 함유 의약 조성물 | |
| PL192959B1 (pl) | Kompozycja zawierająca granulat składający się z rozpuszczalnego w wodzie związku i substancji celulozowej | |
| JPH04103525A (ja) | 難水溶性薬物の持続性製剤化方法 | |
| JPH11335302A (ja) | 安定な医薬組成物 | |
| KR100505899B1 (ko) | 로라타딘과 슈도에페드린을 함유한 캅셀제 조성물 | |
| KR101760278B1 (ko) | 에페리손을 유효 성분으로 함유하는 서방성 미립구의 제조방법 | |
| JPH02223522A (ja) | Ｎｂ―８１８の易吸収性製剤 | |
| JP6733499B2 (ja) | ソリフェナシン含有医薬組成物とその製造方法 | |
| JP3494321B2 (ja) | テオフィリン徐放性マイクロカプセルのドライシロップ剤およびその製造法 | |
| KR20030076634A (ko) | 의약 조성물 | |
| JPS615010A (ja) | 水素添加麦角アルカロイド徐放性製剤及びその製法 | |
| JPH06157313A (ja) | ニカルジピン持続性製剤とその製造方法 |