JPH03206019A - Herb drug-based hair tonic - Google Patents

Abstract

PURPOSE:To provide the title hair tonic excellent in trichogenous, hair growing and hair care effects, free from side effects and high in safety, containing as active ingredients, at least three kinds of crude drug components. CONSTITUTION:At least three kinds of crude drug components selected from carrot, black soybean, polygoni multiflori radix, bean of Psoralea corylifolia, root of Angelica acutiloba, stalk of Mucuna birdwoodiana, rhizome of Cnidium officinale, bark of Schinopsis lerentzii, flower of Carthmus tinctorium, stone of Prunus persica, root of Ladebouriella seseloides, root of Rubia cordifolia and Thujae orientalis folium et ramulus, are mixed, and water-contg. ethanol is added to the mixture to effect immersion. The system is then filtered, thus obtaining the objective hair tonic. Or, the filtrate is lyophilized, and the resulting powder is prepared, through conventional processes, into an external preparation such as a lotion, cream or ointment. The present hair tonic can be used in such a way that normally, an appropriate amount thereof is dripped or coated on the affected parts of the head several times a day and the scalp is massaged.

Description

[Detailed Description of the Invention] <Industrial Application Field> The present invention applies to carrots and black beans. How many birds? This invention relates to a hair tonic containing as an active ingredient a mixture of three or more herbal medicine components selected from bone fat, toki, chicken blood wisteria, kawabou 2 ginseng, safflower, peach kernel, windbreak, madder root, and cypress leaf.

<Prior Art> Various hair tonics containing crude drugs or their extracts as active ingredients are known. Among them, interest in ``101 Hair Regeneration Essence'' has been increasing in recent years. However, regarding wood agents. The herbal medicines that make up these drugs have not yet been completely clarified, and their effectiveness cannot yet be fully determined. Furthermore, there have been reports of side effects recently.

Problems to be Solved by the Invention> The present inventors. The present invention was completed as a result of intensive research to find a hair-growth agent that has excellent hair-growth and hair-growth effects as well as safety.

Components of the Invention The present invention is directed to carrots, black soybeans, crow crows, bone fat, toki, chicken blood wisteria, kawasai, danshen, and safflower. Momohin. This invention relates to a hair growth agent whose effective ingredient is a mixture of three or more crude drug ingredients selected from the roots of Madder 1 and leaves of Akari.

Among the above-mentioned 13 kinds of herbal medicines, the combination of the three kinds of oak leaf, bone graft fat, and windbreak is the most preferred. Among these three herbal medicines.
In addition to these three herbal medicines, chicken blood wisteria is used as a vital medicine to invigorate blood. Preferred examples include appropriate combinations of peony bark, madder root, safflower, peach kernel, and the like.

In such a combination of herbal medicines, the amount of each herbal medicine used is not particularly limited; for example, in the case of the above-mentioned combination of oak leaves, bone grafting fat, and windbreak. Generally a ratio of 1:1:1 (weight ratio), and even 1:0.5:0.5 (weight ratio). 1:1
:0.5 (weight ratio), etc., as appropriate.

The dosage form of the hair tonic of the present invention includes common external preparations such as extracts, lotions, creams, and ointments.

Next, a typical method for producing the hair tonic of the present invention will be explained.

The above-mentioned combination of herbal medicines is mixed, an appropriate amount of aqueous ethanol (usually about 7596) is added to the mixture, and the mixture is mashed. Then filter. The obtained filtrate can be used as it is as the hair growth agent of the present invention. The dipping temperature is not particularly limited, and room temperature is sufficient.

Also, the immersion time is determined by the -fi5 immersion temperature, and the higher the immersion temperature, the shorter the time. For example, when immersion is carried out at a relatively low temperature of 5 to 10℃, the time is usually 3
It only takes about a week, and if immersion is done at a relatively high temperature of 75°C. The time required for this is usually about 10 hours. Also. The mixture of herbal medicines as described above may be soaked in water or hot water for a similar period of time as described above. Among these methods, when hot drying is used, the temperature is preferably 50°C or lower. After soaking, it may be filtered, and ethanol or salt for corrosion prevention may be added to the filtrate. The liquid obtained in this way is. It can be used as the hair nourishing agent of the present invention as it is.

Furthermore, in the above production method, the preparation may be made by mixing liquids extracted individually from each crude drug to be combined.

It is also possible to appropriately mix the filtrates produced by different dipping solutions, temperatures, or times in the above production method, and use the resulting solution as the hair growth agent of the present invention. or. The resulting liquid is freeze-dried and the resulting powder is made into a lotion using conventional formulation techniques. cream. It can also be used as an external preparation such as an ointment.

The hair tonic of the present invention obtained as described above is. Usually the appropriate amount! Simply drop or apply it to the affected area of the head several times a day and massage the scalp.

Effects of the Invention The hair tonic of the present invention is... Hair growth. It has excellent hair growth and hair nourishing effects, and no problems were found in terms of side effects. The present invention will be further explained below with reference to Examples and Test Examples, but the present invention is not limited thereto.

Recipe: Oak leaves 120g Bone fat 120g Windproof 120g According to the above recipe, each herbal medicine was weighed, two mixtures were prepared, and each was placed in a five-way separate flask.

Three squares of 75% (V/V) ethanol solution was added to one flask, and each crude drug was immersed in it. To prepare a high-temperature alcoholic extract, the container was covered with a separable cover equipped with a reflux condenser. The mixture was heated to 75°C using a mantle heater for 10 hours. The extract was filtered through a glass funnel lined with absorbent cotton to separate the extract from the crude drug IA. Next, rinse the remaining herbal medicine with 75% (V/V) ethanol until the total temperature reaches 4°C. The hot extract was collected in a five-sided beaker placed below. Next. Add 75% of the above amount to the other separable flask (
V/V) Add ethanol and soak. It was left for 3 weeks at a low temperature of 5°C to 10°C.

The obtained low-temperature extract was filtered through a glass funnel lined with absorbent cotton in the same way as the high-temperature extract. The extract and the crude drug residue were separated. Then, the sample was washed with 75% (V/V) ethanol so that the entire sample was in quadruple volume. Equal amounts of the obtained high-temperature extract and low-temperature extract were mixed (total amount: 8 J!) and left in a cool, dark place at 5°C to 10°C, and the supernatant was used as a hair growth agent.

Azumaren Riyu prescription: Oak leaf 240g, bone fat 240g, anti-M 24og Weigh each herbal medicine according to the above prescription. 75% or less (V/V
) A high-temperature extract and a low-temperature extract (4 JL each) were prepared by treating with ethanol in the same manner as in Example 1. This was mixed in total amount (81) and left in a cool, dark place at 5°C to 10°C to obtain a supernatant.

Test Example A group of 10 ICR mice were shaved on their backs. It was divided into two experimental sections. Once a day, 0.2 cc'4 of the hair nourishing agent of Example 1 (ethanol solution) was applied to one side, and 0.2 cc of 75% (V/V) z-tanol was applied to the other side. The length of the hair that grew in the bald area was measured 10 days after the start of application and 14 days later, and the length of the hair in the unshorn area was converted into a hair growth index, with the hair growth index being 100. The results obtained are shown in Table 1.

Table 1 As is clear from the table above. It was confirmed that the hair growth agent of the present invention has excellent hair growth and hair growth effects. or. No side effects were observed in the areas to which the hair tonic of the present invention was applied.

Claims (1)

[Claims] A hair tonic containing as an active ingredient a mixture of three or more herbal medicine ingredients selected from ginseng, black soybean, heshouwister, bone fat, dangki, chicken blood wisteria, river, danshen, safflower, peach kernel, windbreak, madder root, and cypress leaf.