JPH0314813B2 - - Google Patents
Info
- Publication number
- JPH0314813B2 JPH0314813B2 JP56090977A JP9097781A JPH0314813B2 JP H0314813 B2 JPH0314813 B2 JP H0314813B2 JP 56090977 A JP56090977 A JP 56090977A JP 9097781 A JP9097781 A JP 9097781A JP H0314813 B2 JPH0314813 B2 JP H0314813B2
- Authority
- JP
- Japan
- Prior art keywords
- dimethylpolysiloxane
- emulsion
- liquid preparation
- present
- polysorbate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 35
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 35
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 35
- 239000007788 liquid Substances 0.000 claims description 28
- 238000004519 manufacturing process Methods 0.000 claims description 16
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical group CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 claims description 13
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 13
- 239000004094 surface-active agent Substances 0.000 claims description 12
- 239000002562 thickening agent Substances 0.000 claims description 8
- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 230000003078 antioxidant effect Effects 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- 238000002360 preparation method Methods 0.000 description 21
- 239000000839 emulsion Substances 0.000 description 20
- 238000000034 method Methods 0.000 description 18
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 15
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 15
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 15
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 15
- 229920000053 polysorbate 80 Polymers 0.000 description 15
- 229910052708 sodium Inorganic materials 0.000 description 15
- 239000011734 sodium Substances 0.000 description 15
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 14
- 239000002245 particle Substances 0.000 description 14
- 229940068968 polysorbate 80 Drugs 0.000 description 14
- 239000001593 sorbitan monooleate Substances 0.000 description 14
- 235000011069 sorbitan monooleate Nutrition 0.000 description 14
- 229940035049 sorbitan monooleate Drugs 0.000 description 14
- 239000000203 mixture Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000008213 purified water Substances 0.000 description 12
- 238000009472 formulation Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- 238000004945 emulsification Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000003860 storage Methods 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 4
- -1 fatty acid esters Chemical class 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 210000003097 mucus Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000010419 fine particle Substances 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 2
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 2
- 241000147041 Guaiacum officinale Species 0.000 description 2
- 235000014121 butter Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229940091561 guaiac Drugs 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229960000984 tocofersolan Drugs 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 206010049119 Emotional distress Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000003961 organosilicon compounds Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56090977A JPS57206611A (en) | 1981-06-15 | 1981-06-15 | Production of stabilized dimethylpolysiloxane solution for internal use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56090977A JPS57206611A (en) | 1981-06-15 | 1981-06-15 | Production of stabilized dimethylpolysiloxane solution for internal use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57206611A JPS57206611A (en) | 1982-12-18 |
| JPH0314813B2 true JPH0314813B2 (he) | 1991-02-27 |
Family
ID=14013573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56090977A Granted JPS57206611A (en) | 1981-06-15 | 1981-06-15 | Production of stabilized dimethylpolysiloxane solution for internal use |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57206611A (he) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420176A (en) * | 1990-06-01 | 1995-05-30 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| US5948387A (en) * | 1990-06-01 | 1999-09-07 | Imarx Pharmaceutical Corp. | Contrast media for ultrasonic imaging |
| WO1997036600A1 (en) * | 1996-03-29 | 1997-10-09 | Ambi Inc. | Polysorbate-containing compositions and their use against helicobacter |
| CN102048690A (zh) * | 2011-01-14 | 2011-05-11 | 四川健能制药有限公司 | 一种二甲硅油乳剂及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5136325A (ja) * | 1974-06-08 | 1976-03-27 | Chizuru Watanabe | Jitenshasokorenshusochi |
| JPS5155783A (he) * | 1974-11-12 | 1976-05-17 | Shiseido Co Ltd |
-
1981
- 1981-06-15 JP JP56090977A patent/JPS57206611A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5136325A (ja) * | 1974-06-08 | 1976-03-27 | Chizuru Watanabe | Jitenshasokorenshusochi |
| JPS5155783A (he) * | 1974-11-12 | 1976-05-17 | Shiseido Co Ltd |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57206611A (en) | 1982-12-18 |
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