JPH03141956A - 骨欠損部及び骨空隙部充填材 - Google Patents
骨欠損部及び骨空隙部充填材Info
- Publication number
- JPH03141956A JPH03141956A JP1279812A JP27981289A JPH03141956A JP H03141956 A JPH03141956 A JP H03141956A JP 1279812 A JP1279812 A JP 1279812A JP 27981289 A JP27981289 A JP 27981289A JP H03141956 A JPH03141956 A JP H03141956A
- Authority
- JP
- Japan
- Prior art keywords
- bone
- filling material
- hydroxyapatite
- sulfuric acid
- acid salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 61
- 239000000463 material Substances 0.000 title claims abstract description 31
- 230000007547 defect Effects 0.000 title claims description 26
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 20
- 239000000945 filler Substances 0.000 claims description 19
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 18
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 18
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 18
- 239000007864 aqueous solution Substances 0.000 claims description 17
- 239000012530 fluid Substances 0.000 claims description 14
- 229920003023 plastic Polymers 0.000 claims description 12
- 239000004033 plastic Substances 0.000 claims description 12
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract description 15
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract description 15
- 239000008187 granular material Substances 0.000 abstract description 7
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 238000013329 compounding Methods 0.000 abstract 1
- 239000011800 void material Substances 0.000 description 16
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 6
- 238000002156 mixing Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 230000035876 healing Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- OKJPEAGHQZHRQV-UHFFFAOYSA-N iodoform Chemical compound IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940036348 bismuth carbonate Drugs 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- GMZOPRQQINFLPQ-UHFFFAOYSA-H dibismuth;tricarbonate Chemical compound [Bi+3].[Bi+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GMZOPRQQINFLPQ-UHFFFAOYSA-H 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 238000001027 hydrothermal synthesis Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
Landscapes
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1279812A JPH03141956A (ja) | 1989-10-30 | 1989-10-30 | 骨欠損部及び骨空隙部充填材 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1279812A JPH03141956A (ja) | 1989-10-30 | 1989-10-30 | 骨欠損部及び骨空隙部充填材 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03141956A true JPH03141956A (ja) | 1991-06-17 |
| JPH051026B2 JPH051026B2 (enrdf_load_stackoverflow) | 1993-01-07 |
Family
ID=17616264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1279812A Granted JPH03141956A (ja) | 1989-10-30 | 1989-10-30 | 骨欠損部及び骨空隙部充填材 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03141956A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005019102A1 (ja) * | 2003-08-22 | 2005-03-03 | National Institute For Materials Science | 金属イオンで一部置換または表面担持されたリン酸カルシウム多孔質球形粒子とリン酸カルシウム多孔質多層球形粒子 |
| WO2009099136A1 (ja) * | 2008-02-07 | 2009-08-13 | Kuraray Medical Inc. | リン酸カルシウム組成物及びその製造方法 |
-
1989
- 1989-10-30 JP JP1279812A patent/JPH03141956A/ja active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005019102A1 (ja) * | 2003-08-22 | 2005-03-03 | National Institute For Materials Science | 金属イオンで一部置換または表面担持されたリン酸カルシウム多孔質球形粒子とリン酸カルシウム多孔質多層球形粒子 |
| US7348060B2 (en) | 2003-08-22 | 2008-03-25 | National Insititute For Materials Science | Porous and spherical calcium phosphate particle comprising metal ion, and porous multilayer calcium phophate particle |
| CN100434357C (zh) * | 2003-08-22 | 2008-11-19 | 独立行政法人物质·材料研究机构 | 用金属离子部分取代或表面担载金属离子的磷酸钙多孔质多层球形粒子 |
| WO2009099136A1 (ja) * | 2008-02-07 | 2009-08-13 | Kuraray Medical Inc. | リン酸カルシウム組成物及びその製造方法 |
| JP5436229B2 (ja) * | 2008-02-07 | 2014-03-05 | クラレノリタケデンタル株式会社 | リン酸カルシウム組成物粉体の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH051026B2 (enrdf_load_stackoverflow) | 1993-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4996030B2 (ja) | ケイ酸塩溶液から調製されるリン酸カルシウムセメント | |
| US5342441A (en) | Biologically compatible hardening material for dental or medical applications | |
| JP5838524B2 (ja) | 象牙質知覚過敏抑制材及びその製造方法 | |
| JP5095034B2 (ja) | 照射後貯蔵安定性の直接注入可能なデュアルペースト型骨セメントを製造するシステムおよびリン酸カルシウム組成物 | |
| Chow et al. | Calcium phosphate cements | |
| US6425949B1 (en) | Hydraulic surgical cement | |
| JPH0773602B2 (ja) | 医科用および歯科用硬化性材料 | |
| WO2005025450A2 (en) | Use of vibration with orthopedic cements | |
| JPH02147064A (ja) | 成形材料およびそれから得られる成形物 | |
| GB2248232A (en) | Cement compositions | |
| US20070092580A1 (en) | Dual-Phase Cement Precursor Systems for Bone Repair | |
| AU2006304730A1 (en) | Dual-phase cement precursor systems for bone repair | |
| JP2009515611A (ja) | 骨修復材 | |
| CN102049062B (zh) | 可注射高效悬浮稳定的磷酸钙骨水泥及其制备方法与应用 | |
| CA2567325A1 (en) | Orthopedic cements comprising a barium apatite contrast agent | |
| JP2020508721A (ja) | インスタントナノ多孔性バイオ人工骨組織合成物エンジニアリングの方法 | |
| JPH05168692A (ja) | 生体硬組織修復用硬化性材料 | |
| JP2018167016A (ja) | 硬組織接合用接着剤、硬組織接合用接着剤キット、及び骨セメント | |
| JPH03141956A (ja) | 骨欠損部及び骨空隙部充填材 | |
| JP3965249B2 (ja) | リン酸カルシウムセメント及びリン酸カルシウムセメント組成物 | |
| JPH0588623B2 (enrdf_load_stackoverflow) | ||
| Chen et al. | Injectable calcium phosphate cements for hard tissue repair | |
| JPH03174348A (ja) | 水硬性リン酸カルシウムセメント | |
| JPH03141955A (ja) | 水硬性リン酸カルシウムセメント硬化液 | |
| TWI436795B (zh) | An injection-type bone filling composition |