JPH0247964B2 - - Google Patents

Info

Publication number
JPH0247964B2
JPH0247964B2 JP59102991A JP10299184A JPH0247964B2 JP H0247964 B2 JPH0247964 B2 JP H0247964B2 JP 59102991 A JP59102991 A JP 59102991A JP 10299184 A JP10299184 A JP 10299184A JP H0247964 B2 JPH0247964 B2 JP H0247964B2
Authority
JP
Japan
Prior art keywords
injection
nicardipine hydrochloride
sorbitol
polyhydric alcohol
same manner
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59102991A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60246313A (ja
Inventor
Katayasu Ogawa
Takeshi Ootani
Shoji Yokota
Masayoshi Ariga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP59102991A priority Critical patent/JPS60246313A/ja
Priority to PT80486A priority patent/PT80486B/pt
Priority to GR851230A priority patent/GR851230B/el
Priority to KR1019850003448A priority patent/KR910003555B1/ko
Priority to AT85303588T priority patent/ATE63810T1/de
Priority to ES543343A priority patent/ES8700567A1/es
Priority to EP85303588A priority patent/EP0162705B1/en
Priority to CA000481975A priority patent/CA1240930A/en
Priority to DE8585303588T priority patent/DE3582954D1/de
Publication of JPS60246313A publication Critical patent/JPS60246313A/ja
Priority to US07/338,402 priority patent/US4880823A/en
Publication of JPH0247964B2 publication Critical patent/JPH0247964B2/ja
Priority to US07/791,358 priority patent/USRE34618E/en
Priority to MX9203588A priority patent/MX9203588A/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP59102991A 1984-05-22 1984-05-22 塩酸ニカルジピンの注射剤およびその製法 Granted JPS60246313A (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP59102991A JPS60246313A (ja) 1984-05-22 1984-05-22 塩酸ニカルジピンの注射剤およびその製法
PT80486A PT80486B (en) 1984-05-22 1985-05-17 Process for producing an injection of nicardipine hydrochloride
GR851230A GR851230B (forum.php) 1984-05-22 1985-05-20
KR1019850003448A KR910003555B1 (ko) 1984-05-22 1985-05-20 니카르디핀 염산염의 주사용 제제의 제조방법
CA000481975A CA1240930A (en) 1984-05-22 1985-05-21 Process for producing an injection of nicardipine hydrochloride
ES543343A ES8700567A1 (es) 1984-05-22 1985-05-21 Un procedimiento para producir una inyeccion de hidroclorurode nicardipina
EP85303588A EP0162705B1 (en) 1984-05-22 1985-05-21 Injection of nicardipine hydrochloride and production thereof
AT85303588T ATE63810T1 (de) 1984-05-22 1985-05-21 Nicardipin-hydrochlorid-injektionsloesungen sowie deren herstellung.
DE8585303588T DE3582954D1 (de) 1984-05-22 1985-05-21 Nicardipin-hydrochlorid-injektionsloesungen sowie deren herstellung.
US07/338,402 US4880823A (en) 1984-05-22 1989-04-12 Injection of nicardinpine hydrochloride and process for the production thereof
US07/791,358 USRE34618E (en) 1984-05-22 1991-11-14 Injection of nicardinpine hydrochloride and process for the production thereof
MX9203588A MX9203588A (es) 1984-05-22 1992-06-26 Inyeccion de hidrocloruro de nicardipina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59102991A JPS60246313A (ja) 1984-05-22 1984-05-22 塩酸ニカルジピンの注射剤およびその製法

Publications (2)

Publication Number Publication Date
JPS60246313A JPS60246313A (ja) 1985-12-06
JPH0247964B2 true JPH0247964B2 (forum.php) 1990-10-23

Family

ID=14342164

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59102991A Granted JPS60246313A (ja) 1984-05-22 1984-05-22 塩酸ニカルジピンの注射剤およびその製法

Country Status (11)

Country Link
US (1) US4880823A (forum.php)
EP (1) EP0162705B1 (forum.php)
JP (1) JPS60246313A (forum.php)
KR (1) KR910003555B1 (forum.php)
AT (1) ATE63810T1 (forum.php)
CA (1) CA1240930A (forum.php)
DE (1) DE3582954D1 (forum.php)
ES (1) ES8700567A1 (forum.php)
GR (1) GR851230B (forum.php)
MX (1) MX9203588A (forum.php)
PT (1) PT80486B (forum.php)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210083A (en) * 1986-07-17 1993-05-11 Ed. Geistlich Sohne A.G. Fur Chemische Industrie Pharmaceutical compositions
GB8617482D0 (en) * 1986-07-17 1986-08-28 Geistlich Soehne Ag Pharmaceutical composition
JPH0696533B2 (ja) * 1987-01-14 1994-11-30 北陸製薬株式会社 キノロンカルボン酸の水性組成物
YU45837B (sh) * 1988-01-18 1992-07-20 LEK TOVARNA FARMACEVTSKIH IN KEMIČKIH IZDELKOV d.d. Postopek za pripravo novega inkluzijskega kompleksa nikardipina oz. njegovega hidroklorida z beta-ciklodekstrinom
BE1003647A5 (fr) * 1989-02-28 1992-05-12 Syntex Inc Composition pharmaceutique de nicardipine pour administration parenterale.
WO1998001138A1 (fr) * 1996-07-04 1998-01-15 Nippon Kayaku Kabushiki Kaisha Injections de succinate sodique de methylprednisolone
US20070112041A1 (en) * 2005-11-16 2007-05-17 Sun Pharmaceutical Industries Limited Nicardipine injection composition
BRPI0710287A2 (pt) * 2006-04-18 2012-05-29 Ekr Therapeutics Inc composição farmacêutica, método para tratar um indivìduo quanto à pressão sangüìnea elevada, complexo de inclusão, e, métodos para tratar e evitar elevações agudas da pressão sangüinea em um indivìduo humano e para induzir a hipotensão em um indivìduo humano.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3720761A (en) * 1968-10-14 1973-03-13 W Hunter Injectable radio-pharmaceutical scanning agent and preparation
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3023495C2 (de) * 1980-06-24 1982-04-08 Kienzle Apparate Gmbh, 7730 Villingen-Schwenningen Diagrammauswertegerät für die Unfalldiagrammauswertung von Fahrtschreiber-Diagrammen
JPS57167967A (en) * 1981-04-08 1982-10-16 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid ester or its salt
DE3205504C2 (de) * 1982-02-16 1983-12-01 Dolorgiet Gmbh & Co Kg, 5300 Bonn Äußerlich anwendbares, Ibuprofen enthaltendes Arzneimittel
JPS58172312A (ja) * 1982-04-02 1983-10-11 Toa Eiyou Kagaku Kogyo Kk ニフエジピン外用剤
DE3212736A1 (de) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
DE3316510A1 (de) * 1983-05-06 1984-11-08 Bayer Ag Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
JPS6016917A (ja) * 1983-07-08 1985-01-28 Yamanouchi Pharmaceut Co Ltd 塩酸ニカルジピンまたはニフエジピンの軟膏剤

Also Published As

Publication number Publication date
US4880823A (en) 1989-11-14
JPS60246313A (ja) 1985-12-06
GR851230B (forum.php) 1985-11-25
CA1240930A (en) 1988-08-23
PT80486B (en) 1986-12-12
EP0162705A3 (en) 1987-01-28
KR850008278A (ko) 1985-12-16
PT80486A (en) 1985-06-01
ES543343A0 (es) 1986-10-16
EP0162705A2 (en) 1985-11-27
MX9203588A (es) 1992-07-31
DE3582954D1 (de) 1991-07-04
ATE63810T1 (de) 1991-06-15
ES8700567A1 (es) 1986-10-16
EP0162705B1 (en) 1991-05-29
KR910003555B1 (ko) 1991-06-05

Similar Documents

Publication Publication Date Title
Chvasta et al. The effect of several ulcerogenic drugs on the canine gastric mucosal barrier
Walkenstein et al. Bioavailability of cimetidine in man
César et al. Thiazide induces water absorption in the inner medullary collecting duct of normal and Brattleboro rats
CA1174601A (en) Pharmaceutical preparations for external use
Oldendorf et al. pH dependence of blood-brain barrier permeability to lactate and nicotine.
JPS61267517A (ja) 記憶障害の経皮治療製剤
JPH0247964B2 (forum.php)
KR20080024118A (ko) 가용화 제제
Weiner et al. Renal excretion of cimetidine.
JP4179631B2 (ja) キサンチン誘導体含有脂肪乳剤
McGahan Ascorbic acid levels in aqueous and vitreous humors of the rabbit: effects of inflammation and ceruloplasmin
PT95770A (pt) Processo para a preparacao de (2,3-dihidroxi-n-metil-propil)-(2-hidroxi-etil)-diamida do acido 5-hidroxiacetamido-2,4,6-triiodo-isoftalico e de agentes de contraste para raios x nao ionicos com alto teor de iodo que a contem
JP2822058B2 (ja) 安定な点眼剤
INAGI et al. Influence of vehicle composition on the penetration of indomethacin through guinea-pig skin
Priest et al. Injectable sodium pentobarbital: stability at room temperature
Zanetti et al. Plasma protein synthesis in patients with low-grade nephrotic proteinuria
Van der Sluijs et al. Binding of drugs with a quaternary ammonium group to alpha-1 acid glycoprotein and asialo alpha-1 acid glycoprotein.
JPH0383924A (ja) 経皮投与用組成物
JP3061062B2 (ja) ビタミンｂ▲下１▼▲下２▼の光安定化方法及びビタミンｂ▲下１▼▲下２▼を含有する医薬組成物
Jochemsen et al. Pharmacokinetics of brotizolam in healthy subjects following intravenous and oral administration.
CN105377848A (zh) 取代的三唑并吡啶的前体药物衍生物
AU720219B2 (en) New dosage form of hydroxocobalamin and its use in cyanide poisoning
JPH07324034A (ja) フマル酸ケトチフェン含有の点眼剤
NL7906835A (nl) Etomidaat-bevattende infusievloeistof, alsmede werkwijze voor het intraveneus toedienen en bereiden daarvan.
USRE34618E (en) Injection of nicardinpine hydrochloride and process for the production thereof

Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term
R154 Certificate of patent or utility model (reissue)

Free format text: JAPANESE INTERMEDIATE CODE: R154