JPH0244319B2 - - Google Patents

Info

Publication number
JPH0244319B2
JPH0244319B2 JP57031555A JP3155582A JPH0244319B2 JP H0244319 B2 JPH0244319 B2 JP H0244319B2 JP 57031555 A JP57031555 A JP 57031555A JP 3155582 A JP3155582 A JP 3155582A JP H0244319 B2 JPH0244319 B2 JP H0244319B2
Authority
JP
Japan
Prior art keywords
complex
maleic anhydride
neocarzinostatin
ncs
sma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57031555A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58149903A (ja
Inventor
Hiroshi Maeda
Ryunosuke Kanamaru
Nakao Ishida
Toshihiko Yoshitake
Minoru Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KAYAKU KK
KURARE KK
YAMANOCHI SEIYAKU KK
Original Assignee
KAYAKU KK
KURARE KK
YAMANOCHI SEIYAKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KAYAKU KK, KURARE KK, YAMANOCHI SEIYAKU KK filed Critical KAYAKU KK
Priority to JP57031555A priority Critical patent/JPS58149903A/ja
Priority to DE8383301027T priority patent/DE3367921D1/de
Priority to EP83301027A priority patent/EP0087957B1/fr
Priority to AT83301027T priority patent/ATE23863T1/de
Priority to CA000422497A priority patent/CA1214458A/fr
Publication of JPS58149903A publication Critical patent/JPS58149903A/ja
Priority to US06/730,823 priority patent/US4732933A/en
Publication of JPH0244319B2 publication Critical patent/JPH0244319B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP57031555A 1982-02-27 1982-02-27 ネオカルチノスタチン複合体の製造法 Granted JPS58149903A (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP57031555A JPS58149903A (ja) 1982-02-27 1982-02-27 ネオカルチノスタチン複合体の製造法
DE8383301027T DE3367921D1 (en) 1982-02-27 1983-02-25 Neocarzinostatin complexes, a method for producing the same, and an antitumor agent containing said complexes as an active component
EP83301027A EP0087957B1 (fr) 1982-02-27 1983-02-25 Complexes de néocarzinostatine, méthode pour leur production, et agent antitumeur contenant ces complexes comme composant actif
AT83301027T ATE23863T1 (de) 1982-02-27 1983-02-25 Neocarzinostatinkomplexe, verfahren zu ihrer herstellung und antitumormittel, das diese komplexe als aktive komponente enhaelt.
CA000422497A CA1214458A (fr) 1982-02-27 1983-02-28 Complexes de neocarzinostatin, methode de production et agent antitumoral les contenant et tant qu'ingredient actif
US06/730,823 US4732933A (en) 1982-02-27 1985-05-06 Neocarzinostatin complexes, a method for producing the same, and an antitumor agent containing said complexes as an active component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57031555A JPS58149903A (ja) 1982-02-27 1982-02-27 ネオカルチノスタチン複合体の製造法

Publications (2)

Publication Number Publication Date
JPS58149903A JPS58149903A (ja) 1983-09-06
JPH0244319B2 true JPH0244319B2 (fr) 1990-10-03

Family

ID=12334426

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57031555A Granted JPS58149903A (ja) 1982-02-27 1982-02-27 ネオカルチノスタチン複合体の製造法

Country Status (1)

Country Link
JP (1) JPS58149903A (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139396A (ja) * 1983-01-31 1984-08-10 Kuraray Co Ltd ネオカルチノスタチン複合体の製造方法
JPS63211238A (ja) * 1987-02-27 1988-09-02 Masayasu Inoue 抗潰瘍剤
JP2556865B2 (ja) * 1986-09-19 1996-11-27 山之内製薬株式会社 ネオカルチノスタチン誘導体の非注射投与用組成物
GB0123232D0 (en) * 2001-09-26 2001-11-21 Smith & Nephew Polymers
US7682630B2 (en) 2003-05-26 2010-03-23 Hiroshi Maeda Antitumor agent and process for producing the same
AU2006238072A1 (en) * 2005-04-18 2006-10-26 Hiroshi Maeda Polymeric pharmaceutical agent for treatment of cancer and process for production of the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53117095A (en) * 1977-03-24 1978-10-13 Hiroshi Maeda Neocarcinostachin derivative and producing process thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53117095A (en) * 1977-03-24 1978-10-13 Hiroshi Maeda Neocarcinostachin derivative and producing process thereof

Also Published As

Publication number Publication date
JPS58149903A (ja) 1983-09-06

Similar Documents

Publication Publication Date Title
JP5369137B2 (ja) 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
RU2384593C2 (ru) Таксаны, ковалентно связанные с гиалуроновой кислотой или производными гиалуроновой кислоты
JP4272537B2 (ja) Y型分鎖親水性ポリマー誘導体、それらの調製方法、前記誘導体および薬剤分子の結合生成物、ならびに前記結合生成物を含む医薬組成物
JP4039466B2 (ja) 新規アンスラサイクリン系化合物誘導体及びそれを含む医薬製剤
JPWO2004039869A1 (ja) カンプトテシン類の高分子誘導体
US5130126A (en) Polymer-drug conjugate and a method of producing it
JP4663233B2 (ja) ベンジル脱離系を利用する高分子チオール結合プロドラッグ
CN110591078B (zh) 还原/pH双重响应性阿霉素前药的制备方法
JP2005513006A6 (ja) ベンジル脱離系を利用する高分子チオール結合プロドラッグ
EP0087957B1 (fr) Complexes de néocarzinostatine, méthode pour leur production, et agent antitumeur contenant ces complexes comme composant actif
CN108026271A (zh) 6配位铂络合物的高分子偶联物
EP4066860A1 (fr) Médicament conjugué au polyéthylene glycol et son procédé de préparation et son utilisation
JPH0244319B2 (fr)
EP0354836A1 (fr) Polymères iodés à squelette dextrane, leurs procédés de préparation et leurs applications comme produits de contraste
JPH0123480B2 (fr)
KR100348380B1 (ko) 항종양미토크산트론중합체조성물
JPH0278699A (ja) ベンゾイルウレア系化合物・アルブミン複合体
EP0452179A2 (fr) Médicament combinÀ© avec un polymère pour le traitement gastrique et son procédé de préparation
JPS6330886B2 (fr)
CN111346234B (zh) 去铁胺-八臂星型聚乙二醇结合物及其应用
CN1206257C (zh) 亲水性聚合物-水飞蓟提取物的结合物以及包含该结合物的药物组合物
CN110787302A (zh) 一种pH敏感青蒿琥酯聚合物前药及其制备方法、治疗结肠癌的药物组合物
JPH05132431A (ja) 高分子化薬剤およびその製造法
RU2805370C1 (ru) Лекарственное средство, представляющее собой конъюгат с полиэтиленгликолем, способ его получения и его применение
CN114948926A (zh) 一种线粒体靶向的卡巴他赛药物前体及其制备方法和应用