JPH02167229A - かわらたけ由来の蛋白多糖体の粒状製剤 - Google Patents
かわらたけ由来の蛋白多糖体の粒状製剤Info
- Publication number
- JPH02167229A JPH02167229A JP1225284A JP22528489A JPH02167229A JP H02167229 A JPH02167229 A JP H02167229A JP 1225284 A JP1225284 A JP 1225284A JP 22528489 A JP22528489 A JP 22528489A JP H02167229 A JPH02167229 A JP H02167229A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- sieve
- krestin
- granulation
- minutes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 37
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 37
- 150000004676 glycans Chemical class 0.000 title claims abstract description 32
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 32
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 32
- 239000000126 substance Substances 0.000 title abstract description 13
- 241000222355 Trametes versicolor Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 claims abstract description 65
- 238000005469 granulation Methods 0.000 claims abstract description 44
- 230000003179 granulation Effects 0.000 claims abstract description 44
- 238000004090 dissolution Methods 0.000 claims abstract description 34
- 239000000654 additive Substances 0.000 claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000001125 extrusion Methods 0.000 claims abstract description 13
- 108010001062 polysaccharide-K Proteins 0.000 claims description 50
- 238000002360 preparation method Methods 0.000 claims description 50
- 239000002245 particle Substances 0.000 claims description 34
- 238000009472 formulation Methods 0.000 claims description 18
- 238000009826 distribution Methods 0.000 claims description 12
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims description 7
- 238000005096 rolling process Methods 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 3
- 238000007922 dissolution test Methods 0.000 abstract description 29
- 239000011230 binding agent Substances 0.000 abstract description 16
- 230000000996 additive effect Effects 0.000 abstract description 14
- 230000035622 drinking Effects 0.000 abstract description 13
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract description 10
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract description 10
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract description 10
- 230000000144 pharmacologic effect Effects 0.000 abstract description 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 8
- 229930006000 Sucrose Natural products 0.000 abstract description 8
- 229920002472 Starch Polymers 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 239000001341 hydroxy propyl starch Substances 0.000 abstract description 2
- 235000013828 hydroxypropyl starch Nutrition 0.000 abstract description 2
- 239000000843 powder Substances 0.000 description 68
- 235000018102 proteins Nutrition 0.000 description 30
- 239000003814 drug Substances 0.000 description 20
- 239000000243 solution Substances 0.000 description 20
- 229940079593 drug Drugs 0.000 description 19
- 230000000694 effects Effects 0.000 description 17
- 239000008187 granular material Substances 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
- 206010028980 Neoplasm Diseases 0.000 description 13
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
- 230000000259 anti-tumor effect Effects 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 7
- 238000001694 spray drying Methods 0.000 description 7
- 229920002678 cellulose Polymers 0.000 description 6
- 239000001913 cellulose Substances 0.000 description 6
- 239000007884 disintegrant Substances 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 229920002261 Corn starch Polymers 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 239000008120 corn starch Substances 0.000 description 5
- 238000004898 kneading Methods 0.000 description 5
- 239000000314 lubricant Substances 0.000 description 5
- 235000019359 magnesium stearate Nutrition 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 230000000503 lectinlike effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- -1 Krestin Chemical class 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 235000010724 Wisteria floribunda Nutrition 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 244000215068 Acacia senegal Species 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 238000002679 ablation Methods 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- 238000005199 ultracentrifugation Methods 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- FYGDTMLNYKFZSV-WFYNLLPOSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,3s,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-WFYNLLPOSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- 101100120289 Drosophila melanogaster Flo1 gene Proteins 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 240000000599 Lentinula edodes Species 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 208000006268 Sarcoma 180 Diseases 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 229940008396 carrot extract Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000005772 leucine Nutrition 0.000 description 1
- 235000015250 liver sausages Nutrition 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000014393 valine Nutrition 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1225284A JPH02167229A (ja) | 1988-09-01 | 1989-08-31 | かわらたけ由来の蛋白多糖体の粒状製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21917788 | 1988-09-01 | ||
| JP63-219177 | 1988-09-01 | ||
| JP1225284A JPH02167229A (ja) | 1988-09-01 | 1989-08-31 | かわらたけ由来の蛋白多糖体の粒状製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02167229A true JPH02167229A (ja) | 1990-06-27 |
| JPH0549649B2 JPH0549649B2 (en, 2012) | 1993-07-26 |
Family
ID=16731409
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1225284A Granted JPH02167229A (ja) | 1988-09-01 | 1989-08-31 | かわらたけ由来の蛋白多糖体の粒状製剤 |
| JP1225285A Granted JPH02174722A (ja) | 1988-09-01 | 1989-08-31 | かわらたけ由来の蛋白多糖体の粒状製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1225285A Granted JPH02174722A (ja) | 1988-09-01 | 1989-08-31 | かわらたけ由来の蛋白多糖体の粒状製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JPH02167229A (en, 2012) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002526437A (ja) * | 1998-09-18 | 2002-08-20 | バイエル アクチェンゲゼルシャフト | アジテーション非依存性薬学的マルチプル−ユニット持効性製剤およびその製法 |
| JP2009541226A (ja) * | 2006-06-23 | 2009-11-26 | 天津天士力制▲薬▼股▲分▼有限公司 | 顆粒剤及びその製造方法 |
| JP2014214125A (ja) * | 2013-04-25 | 2014-11-17 | 小林製薬株式会社 | 錠剤の製造方法 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4752233B2 (ja) * | 2001-04-27 | 2011-08-17 | 味の素株式会社 | 免疫賦活剤 |
-
1989
- 1989-08-31 JP JP1225284A patent/JPH02167229A/ja active Granted
- 1989-08-31 JP JP1225285A patent/JPH02174722A/ja active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002526437A (ja) * | 1998-09-18 | 2002-08-20 | バイエル アクチェンゲゼルシャフト | アジテーション非依存性薬学的マルチプル−ユニット持効性製剤およびその製法 |
| JP2009541226A (ja) * | 2006-06-23 | 2009-11-26 | 天津天士力制▲薬▼股▲分▼有限公司 | 顆粒剤及びその製造方法 |
| US8951568B2 (en) | 2006-06-23 | 2015-02-10 | Tasly Pharmaceuticals Group Co., Ltd. | Granule and preparation method thereof |
| JP2014214125A (ja) * | 2013-04-25 | 2014-11-17 | 小林製薬株式会社 | 錠剤の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0549649B2 (en, 2012) | 1993-07-26 |
| JPH0549650B2 (en, 2012) | 1993-07-26 |
| JPH02174722A (ja) | 1990-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0235986B1 (en) | Slow release formulation | |
| TWI296198B (en) | Immediate release pharmaceutical granule compositions and a continuous process for making them | |
| DE69023183T2 (de) | Rotogranulate und geschmacksabdeckende Überzüge zur Herstellung pharmazeutischer Kautabletten. | |
| JP5439366B2 (ja) | 偏析防止効果に優れるセルロース粉末及びその組成物 | |
| JP2001511156A (ja) | 高いバイオアベイラビリティーを有するフェノフィブレート医薬組成物及びそれを調製するための方法 | |
| JP6216074B2 (ja) | 微小セルロース粉末 | |
| ZA200410386B (en) | Medicinal composition for regulating release and process for producing the same | |
| WO1988006457A1 (en) | Medicinal composition containing albumin as carrier and process for its preparation | |
| CN1300590A (zh) | 膜衣用作口服剂型的味道掩蔽包衣的用途 | |
| WO2004106416A1 (ja) | セルロース粉末 | |
| EP2344138B1 (de) | Verwendung von copolymeren auf basis von polyethern und vinylmonomeren als bindemittel für feste wirkstoffhaltige dosierungsformen | |
| WO2002002083A1 (fr) | Tablette se desintegrant rapidement dans la bouche et procede de production correspondant | |
| JPH0717866A (ja) | 医薬組成物 | |
| KR102377914B1 (ko) | 분쇄 유당 또는 조립 유당을 포함하는 붕해성 입자 조성물 | |
| CA2245370C (en) | Production of pharmaceutical formulations for treatment of edema and venous disorders | |
| JP5232472B2 (ja) | 向上された生体利用効率を備えるプランルカスト固体分散体組成物およびその固体分散体の製造方法 | |
| TWI724534B (zh) | 纖維素粉末、錠劑及錠劑之製造方法 | |
| JP2013032351A (ja) | 漢方又は生薬製剤及びその製造方法 | |
| JPH02167229A (ja) | かわらたけ由来の蛋白多糖体の粒状製剤 | |
| JP2018083923A (ja) | セルロース分散液、セルロース分散液の製造方法、成形体組成物、成形体、及び成形体組成物の製造方法 | |
| CN103800297B (zh) | 一种吡喹酮组合物胃内漂浮型缓释片及其制备方法 | |
| JP2018002695A (ja) | 結晶セルロース混合粉末、組成物、及び成形体の製造方法 | |
| CN111936168A (zh) | 易服用性颗粒剂及其制造方法 | |
| JPH10502937A (ja) | フシジン酸錠剤の製法 | |
| JP2000516601A (ja) | 水溶性化合物及びセルロースを含有する粒状物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080726 Year of fee payment: 15 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080726 Year of fee payment: 15 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090726 Year of fee payment: 16 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090726 Year of fee payment: 16 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100726 Year of fee payment: 17 |
|
| EXPY | Cancellation because of completion of term | ||
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100726 Year of fee payment: 17 |