JPH02157225A - 相乗作用を有する抗菌組成物 - Google Patents
相乗作用を有する抗菌組成物Info
- Publication number
- JPH02157225A JPH02157225A JP1271441A JP27144189A JPH02157225A JP H02157225 A JPH02157225 A JP H02157225A JP 1271441 A JP1271441 A JP 1271441A JP 27144189 A JP27144189 A JP 27144189A JP H02157225 A JPH02157225 A JP H02157225A
- Authority
- JP
- Japan
- Prior art keywords
- ceftizoxime
- ester
- fce
- fce22101
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 11
- 230000002195 synergetic effect Effects 0.000 title claims abstract description 7
- NNULBSISHYWZJU-LLKWHZGFSA-N ceftizoxime Chemical compound N([C@@H]1C(N2C(=CCS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 NNULBSISHYWZJU-LLKWHZGFSA-N 0.000 claims abstract description 16
- 229960001991 ceftizoxime Drugs 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 150000002148 esters Chemical class 0.000 claims abstract description 12
- 239000002253 acid Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 208000035143 Bacterial infection Diseases 0.000 claims description 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 2
- VIKZIPIQNIJTFL-WMZJFQQLSA-N (2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetamide Chemical compound CO\N=C(/C(N)=O)C1=CSC(N)=N1 VIKZIPIQNIJTFL-WMZJFQQLSA-N 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- IKQNRQOUOZJHTR-UHFFFAOYSA-N 3-(carbamoyloxymethyl)-6-(1-hydroxyethyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical compound S1C(COC(N)=O)=C(C(O)=O)N2C(=O)C(C(O)C)C21 IKQNRQOUOZJHTR-UHFFFAOYSA-N 0.000 abstract description 16
- 230000003115 biocidal effect Effects 0.000 abstract description 4
- 208000015181 infectious disease Diseases 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 210000002345 respiratory system Anatomy 0.000 abstract description 2
- NNULBSISHYWZJU-QHDYGNBISA-N (6R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound NC=1SC=C(N=1)C(C(=O)NC1[C@@H]2N(C(=CCS2)C(=O)O)C1=O)=NOC NNULBSISHYWZJU-QHDYGNBISA-N 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 150000002961 penems Chemical class 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8822409A IT1231487B (it) | 1988-10-24 | 1988-10-24 | Composizione sinergica antibatterica contenente penem e ceftizoximaf |
| IT22409A/88 | 1988-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH02157225A true JPH02157225A (ja) | 1990-06-18 |
Family
ID=11195923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1271441A Pending JPH02157225A (ja) | 1988-10-24 | 1989-10-18 | 相乗作用を有する抗菌組成物 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPH02157225A (it) |
| DE (1) | DE3934855A1 (it) |
| GB (1) | GB2223945B (it) |
| IT (1) | IT1231487B (it) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3618813A1 (de) * | 1986-06-04 | 1987-12-10 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung bakterieller infektionen |
-
1988
- 1988-10-24 IT IT8822409A patent/IT1231487B/it active
-
1989
- 1989-10-18 JP JP1271441A patent/JPH02157225A/ja active Pending
- 1989-10-19 DE DE3934855A patent/DE3934855A1/de not_active Withdrawn
- 1989-10-23 GB GB8923809A patent/GB2223945B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3934855A1 (de) | 1990-04-26 |
| GB2223945A (en) | 1990-04-25 |
| IT1231487B (it) | 1991-12-07 |
| IT8822409A0 (it) | 1988-10-24 |
| GB8923809D0 (en) | 1989-12-13 |
| GB2223945B (en) | 1992-03-04 |
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