JPH0156380B2 - - Google Patents
Info
- Publication number
- JPH0156380B2 JPH0156380B2 JP58225266A JP22526683A JPH0156380B2 JP H0156380 B2 JPH0156380 B2 JP H0156380B2 JP 58225266 A JP58225266 A JP 58225266A JP 22526683 A JP22526683 A JP 22526683A JP H0156380 B2 JPH0156380 B2 JP H0156380B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- compound
- blood coagulation
- carbonyl groups
- tests
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000023555 blood coagulation Effects 0.000 claims description 20
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 15
- -1 cyclic organic compound Chemical class 0.000 claims description 8
- 150000001923 cyclic compounds Chemical class 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 description 21
- 239000008280 blood Substances 0.000 description 21
- 150000001875 compounds Chemical class 0.000 description 17
- 238000012360 testing method Methods 0.000 description 10
- 238000009534 blood test Methods 0.000 description 9
- 210000002966 serum Anatomy 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 5
- 125000001183 hydrocarbyl group Chemical group 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 102000000429 Factor XII Human genes 0.000 description 4
- 108010080865 Factor XII Proteins 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical compound C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- WOAHJDHKFWSLKE-UHFFFAOYSA-N 1,2-benzoquinone Chemical group O=C1C=CC=CC1=O WOAHJDHKFWSLKE-UHFFFAOYSA-N 0.000 description 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 3
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 3
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 3
- 229920002079 Ellagic acid Polymers 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- LNTHITQWFMADLM-UHFFFAOYSA-N anhydrous gallic acid Natural products OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000003114 blood coagulation factor Substances 0.000 description 3
- 229940019700 blood coagulation factors Drugs 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000004132 ellagic acid Nutrition 0.000 description 3
- 229960002852 ellagic acid Drugs 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 3
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- OILAIQUEIWYQPH-UHFFFAOYSA-N cyclohexane-1,2-dione Chemical group O=C1CCCCC1=O OILAIQUEIWYQPH-UHFFFAOYSA-N 0.000 description 2
- 235000004515 gallic acid Nutrition 0.000 description 2
- 229940074391 gallic acid Drugs 0.000 description 2
- 150000002391 heterocyclic compounds Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- HCZKYJDFEPMADG-UHFFFAOYSA-N nordihydroguaiaretic acid Chemical compound C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 241000519695 Ilex integra Species 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000003262 carboxylic acid ester group Chemical group [H]C([H])([*:2])OC(=O)C([H])([H])[*:1] 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- POLCUAVZOMRGSN-UHFFFAOYSA-N dipropyl ether Chemical compound CCCOCCC POLCUAVZOMRGSN-UHFFFAOYSA-N 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58225266A JPS60115519A (ja) | 1983-11-28 | 1983-11-28 | 血液凝固促進剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58225266A JPS60115519A (ja) | 1983-11-28 | 1983-11-28 | 血液凝固促進剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60115519A JPS60115519A (ja) | 1985-06-22 |
| JPH0156380B2 true JPH0156380B2 (ko) | 1989-11-29 |
Family
ID=16826622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58225266A Granted JPS60115519A (ja) | 1983-11-28 | 1983-11-28 | 血液凝固促進剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60115519A (ko) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2746386B2 (ja) * | 1988-09-07 | 1998-05-06 | 清水製薬株式会社 | 全血を用いた血液凝固能検査法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57175115A (en) * | 1981-04-21 | 1982-10-28 | Sekisui Chem Co Ltd | Blood coagulation accelerator |
| JPS57187658A (en) * | 1981-05-13 | 1982-11-18 | Sekisui Chem Co Ltd | Container for blood inspection |
| JPS57197469A (en) * | 1981-05-29 | 1982-12-03 | Sekisui Chem Co Ltd | Vessel for blood inspection |
| JPS57197471A (en) * | 1981-05-29 | 1982-12-03 | Sekisui Chem Co Ltd | Blood coagulation accelerant |
| JPS58114659A (ja) * | 1981-12-28 | 1983-07-08 | Matsushita Electric Ind Co Ltd | インタ−ホン装置 |
| JPS58114661A (ja) * | 1981-12-23 | 1983-07-08 | シ−メンス・アクチエンゲゼルシヤフト | 英数字伝送方法 |
-
1983
- 1983-11-28 JP JP58225266A patent/JPS60115519A/ja active Granted
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57175115A (en) * | 1981-04-21 | 1982-10-28 | Sekisui Chem Co Ltd | Blood coagulation accelerator |
| JPS57187658A (en) * | 1981-05-13 | 1982-11-18 | Sekisui Chem Co Ltd | Container for blood inspection |
| JPS57197469A (en) * | 1981-05-29 | 1982-12-03 | Sekisui Chem Co Ltd | Vessel for blood inspection |
| JPS57197471A (en) * | 1981-05-29 | 1982-12-03 | Sekisui Chem Co Ltd | Blood coagulation accelerant |
| JPS58114661A (ja) * | 1981-12-23 | 1983-07-08 | シ−メンス・アクチエンゲゼルシヤフト | 英数字伝送方法 |
| JPS58114659A (ja) * | 1981-12-28 | 1983-07-08 | Matsushita Electric Ind Co Ltd | インタ−ホン装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60115519A (ja) | 1985-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0475860B2 (ko) | ||
| US3704282A (en) | Catecholamine antigens and antibodies specific therefor | |
| JPH0339080B2 (ko) | ||
| JPS6154008B2 (ko) | ||
| KR950006614B1 (ko) | 혈액응고 촉진방법 | |
| Mohammed et al. | Multiple active forms of thrombin: binding to platelets and effects on platelet function. | |
| JPH0156380B2 (ko) | ||
| JPH0546502B2 (ko) | ||
| JPH08154697A (ja) | 血液検査用容器 | |
| Fantl | Thiol groups of blood platelets in relation to clot retraction | |
| US2495298A (en) | Process for the preparation of thrombin | |
| US3922145A (en) | Hypothyroid serum control | |
| JPH084499B2 (ja) | 加水分解酵素活性促進剤 | |
| JP2512527B2 (ja) | 血液凝固促進剤および血液検査用容器 | |
| JPH0151942B2 (ko) | ||
| JPS63275954A (ja) | 血液検査用容器 | |
| JPH0354303B2 (ko) | ||
| JPH0114240B2 (ko) | ||
| JPH0643342B2 (ja) | 血液凝固促進剤 | |
| JPH065229B2 (ja) | 血液凝固促進剤 | |
| JPH0515437B2 (ko) | ||
| JP3514848B2 (ja) | 血液検査用容器 | |
| JPH065230B2 (ja) | 血液凝固促進剤 | |
| JPH0725672B2 (ja) | 血液凝固促進剤 | |
| JPH071272B2 (ja) | 血液凝固促進剤 |