JPH0153247B2 - - Google Patents

Info

Publication number
JPH0153247B2
JPH0153247B2 JP55039150A JP3915080A JPH0153247B2 JP H0153247 B2 JPH0153247 B2 JP H0153247B2 JP 55039150 A JP55039150 A JP 55039150A JP 3915080 A JP3915080 A JP 3915080A JP H0153247 B2 JPH0153247 B2 JP H0153247B2
Authority
JP
Japan
Prior art keywords
indomethacin
hydroxy
difluorophenyl
acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP55039150A
Other languages
English (en)
Japanese (ja)
Other versions
JPS55130915A (en
Inventor
Shen Tsunnyun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS55130915A publication Critical patent/JPS55130915A/ja
Publication of JPH0153247B2 publication Critical patent/JPH0153247B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP3915080A 1979-03-28 1980-03-28 Improved antiinflammatory composition having reduced ulcer formation Granted JPS55130915A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/024,639 US4228161A (en) 1979-03-28 1979-03-28 Anti-inflammatory combination having reduced ulcerogenicity

Publications (2)

Publication Number Publication Date
JPS55130915A JPS55130915A (en) 1980-10-11
JPH0153247B2 true JPH0153247B2 (enExample) 1989-11-13

Family

ID=21821627

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3915080A Granted JPS55130915A (en) 1979-03-28 1980-03-28 Improved antiinflammatory composition having reduced ulcer formation

Country Status (13)

Country Link
US (1) US4228161A (enExample)
EP (1) EP0017169B1 (enExample)
JP (1) JPS55130915A (enExample)
AR (1) AR230953A1 (enExample)
AT (1) ATE2718T1 (enExample)
AU (1) AU531174B2 (enExample)
CA (1) CA1124648A (enExample)
DE (1) DE3062251D1 (enExample)
FI (1) FI800921A7 (enExample)
IE (1) IE49652B1 (enExample)
NZ (1) NZ193239A (enExample)
PT (1) PT71015B (enExample)
ZA (1) ZA801821B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU183408B (en) 1981-04-28 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing oral ratard pharmaceutical compositions
WO1983001382A1 (en) * 1981-10-13 1983-04-28 Mroszczak, Edward Gastrointestinal sparing thioester pro-drugs
DE3366910D1 (en) * 1982-04-27 1986-11-20 Noristan Ltd Pharmaceutical compositions and preparation thereof
GB8607662D0 (en) * 1986-03-27 1986-04-30 Rainsford K D Pharmaceutical formulation
GB2201591B (en) * 1987-03-02 1990-11-14 Ricerfarma Srl Analgesic antipyretic and anti-inflammatory compositions.
US6767899B1 (en) * 2000-08-29 2004-07-27 Leiner Health Services Corp. Composition and method for treatment of conditions having an inflammatory component

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161564A (en) * 1960-10-03 1964-12-15 Salsbury S Lab Dr Veterinary composition containing halo-nitro-benzamides and methods of using same
US3714226A (en) * 1970-06-09 1973-01-30 Merck & Co Inc Phenyl benzoic acid compounds
US3674870A (en) * 1970-06-09 1972-07-04 Merck & Co Inc Phenyl benzoic acid compounds in compositions and methods for treating inflammation
HU170329B (enExample) 1974-12-12 1977-05-28
US4016268A (en) * 1975-10-06 1977-04-05 Morton-Norwich Products, Inc. Method of combatting gastric ulceration
GB1509979A (en) * 1975-11-28 1978-05-10 Fisons Ltd Pharmaceutical compositions containing aspirin or indomethacin

Also Published As

Publication number Publication date
CA1124648A (en) 1982-06-01
PT71015B (en) 1981-06-25
EP0017169A1 (en) 1980-10-15
AR230953A1 (es) 1984-08-31
IE49652B1 (en) 1985-11-13
DE3062251D1 (en) 1983-04-14
ZA801821B (en) 1981-11-25
ATE2718T1 (de) 1983-03-15
PT71015A (en) 1980-04-01
AU531174B2 (en) 1983-08-11
EP0017169B1 (en) 1983-03-09
US4228161A (en) 1980-10-14
FI800921A7 (fi) 1981-01-01
NZ193239A (en) 1984-07-31
AU5653780A (en) 1980-10-02
JPS55130915A (en) 1980-10-11
IE800633L (en) 1980-09-28

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