JPH0143549B2 - - Google Patents
Info
- Publication number
- JPH0143549B2 JPH0143549B2 JP58008797A JP879783A JPH0143549B2 JP H0143549 B2 JPH0143549 B2 JP H0143549B2 JP 58008797 A JP58008797 A JP 58008797A JP 879783 A JP879783 A JP 879783A JP H0143549 B2 JPH0143549 B2 JP H0143549B2
- Authority
- JP
- Japan
- Prior art keywords
- peptone
- plasminogen activator
- cells
- animal meat
- fibrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000001888 Peptone Substances 0.000 claims description 26
- 108010080698 Peptones Proteins 0.000 claims description 26
- 235000019319 peptone Nutrition 0.000 claims description 26
- 108010001014 Plasminogen Activators Proteins 0.000 claims description 24
- 102000001938 Plasminogen Activators Human genes 0.000 claims description 24
- 229940127126 plasminogen activator Drugs 0.000 claims description 24
- 238000004519 manufacturing process Methods 0.000 claims description 19
- 235000013372 meat Nutrition 0.000 claims description 18
- 210000004027 cell Anatomy 0.000 claims description 16
- 241001465754 Metazoa Species 0.000 claims description 15
- 102000009123 Fibrin Human genes 0.000 claims description 13
- 108010073385 Fibrin Proteins 0.000 claims description 13
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 13
- 229950003499 fibrin Drugs 0.000 claims description 13
- 210000001840 diploid cell Anatomy 0.000 claims description 9
- 210000003953 foreskin Anatomy 0.000 claims description 6
- 241000282412 Homo Species 0.000 claims description 3
- 210000005265 lung cell Anatomy 0.000 claims description 3
- 108010062580 Concanavalin A Proteins 0.000 claims description 2
- 230000009849 deactivation Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 24
- 239000000243 solution Substances 0.000 description 19
- 235000015278 beef Nutrition 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000012190 activator Substances 0.000 description 8
- 238000000354 decomposition reaction Methods 0.000 description 8
- 108010009004 proteose-peptone Proteins 0.000 description 8
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 4
- 102000057297 Pepsin A Human genes 0.000 description 4
- 108090000284 Pepsin A Proteins 0.000 description 4
- 102000013566 Plasminogen Human genes 0.000 description 4
- 108010051456 Plasminogen Proteins 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 4
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- 239000001569 carbon dioxide Substances 0.000 description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 229940111202 pepsin Drugs 0.000 description 4
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- 239000011734 sodium Substances 0.000 description 4
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000283153 Cetacea Species 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000008946 Fibrinogen Human genes 0.000 description 3
- 108010049003 Fibrinogen Proteins 0.000 description 3
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- 102000004407 Lactalbumin Human genes 0.000 description 3
- 108090000942 Lactalbumin Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- 229940012952 fibrinogen Drugs 0.000 description 3
- 239000003527 fibrinolytic agent Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002806 plasmin inhibitor Substances 0.000 description 3
- 229960000103 thrombolytic agent Drugs 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- KWTQSFXGGICVPE-UHFFFAOYSA-N 2-amino-5-(diaminomethylideneamino)pentanoic acid;hydron;chloride Chemical compound Cl.OC(=O)C(N)CCCN=C(N)N KWTQSFXGGICVPE-UHFFFAOYSA-N 0.000 description 2
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 235000019743 Choline chloride Nutrition 0.000 description 2
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- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
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- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 2
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- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
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- 210000002105 tongue Anatomy 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
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- 210000000626 ureter Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
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- 239000011719 vitamin A Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940041603 vitamin k 3 Drugs 0.000 description 1
Landscapes
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58008797A JPS59134733A (ja) | 1983-01-24 | 1983-01-24 | 生物活性物質の製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58008797A JPS59134733A (ja) | 1983-01-24 | 1983-01-24 | 生物活性物質の製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59134733A JPS59134733A (ja) | 1984-08-02 |
| JPH0143549B2 true JPH0143549B2 (enExample) | 1989-09-21 |
Family
ID=11702852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58008797A Granted JPS59134733A (ja) | 1983-01-24 | 1983-01-24 | 生物活性物質の製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59134733A (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60259187A (ja) * | 1984-04-19 | 1985-12-21 | マイルス・ラボラトリ−ス・インコ−ポレ−テツド | プラスミノーゲン活性化因子を増収する方法 |
-
1983
- 1983-01-24 JP JP58008797A patent/JPS59134733A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59134733A (ja) | 1984-08-02 |
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