JPH0133449B2 - - Google Patents
Info
- Publication number
- JPH0133449B2 JPH0133449B2 JP55080465A JP8046580A JPH0133449B2 JP H0133449 B2 JPH0133449 B2 JP H0133449B2 JP 55080465 A JP55080465 A JP 55080465A JP 8046580 A JP8046580 A JP 8046580A JP H0133449 B2 JPH0133449 B2 JP H0133449B2
- Authority
- JP
- Japan
- Prior art keywords
- freeze
- vaccine
- live
- titer
- drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004108 freeze drying Methods 0.000 claims description 16
- 229940041323 measles vaccine Drugs 0.000 claims description 11
- 150000005846 sugar alcohols Chemical class 0.000 claims description 11
- 150000002016 disaccharides Chemical class 0.000 claims description 6
- 229920002307 Dextran Polymers 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 5
- 229920000159 gelatin Polymers 0.000 claims description 5
- 239000008273 gelatin Substances 0.000 claims description 5
- 235000019322 gelatine Nutrition 0.000 claims description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 4
- 230000008014 freezing Effects 0.000 claims description 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 description 22
- 239000000243 solution Substances 0.000 description 10
- 239000000047 product Substances 0.000 description 8
- 239000011550 stock solution Substances 0.000 description 8
- 241000712079 Measles morbillivirus Species 0.000 description 7
- 229960003213 live attenuated measles Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 241000700605 Viruses Species 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000002238 attenuated effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- 229940124862 Measles virus vaccine Drugs 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- FBPFZTCFMRRESA-FBXFSONDSA-N Allitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-FBXFSONDSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-altritol Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 description 1
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 1
- FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 description 1
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-threitol Chemical compound OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- PXXXZVXOMPUQRY-NKNAPQMISA-N OC(=O)[C@@H](N)CCC(O)=O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O Chemical compound OC(=O)[C@@H](N)CCC(O)=O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O PXXXZVXOMPUQRY-NKNAPQMISA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8046580A JPS577423A (en) | 1980-06-13 | 1980-06-13 | Frozen or freeze-dried live measles vaccine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8046580A JPS577423A (en) | 1980-06-13 | 1980-06-13 | Frozen or freeze-dried live measles vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS577423A JPS577423A (en) | 1982-01-14 |
| JPH0133449B2 true JPH0133449B2 (de) | 1989-07-13 |
Family
ID=13719000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8046580A Granted JPS577423A (en) | 1980-06-13 | 1980-06-13 | Frozen or freeze-dried live measles vaccine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS577423A (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5997136A (ja) * | 1982-11-26 | 1984-06-04 | Fuji Photo Film Co Ltd | 感光性組成物 |
| JP2571354B2 (ja) * | 1983-06-01 | 1997-01-16 | 富士写真フイルム株式会社 | 感光性組成物 |
| FR2742756B1 (fr) | 1995-12-22 | 1998-04-03 | Pasteur Merieux Serums Vacc | Stabilisants pour vaccins vivants, vaccins les contenant et procedes pour leur preparation |
| US6051238A (en) * | 1996-12-20 | 2000-04-18 | Merck & Co., Inc. | Stabilizers for lyophilized mumps vaccines |
| US6290967B1 (en) * | 1996-12-20 | 2001-09-18 | Merck & Co., Inc. | Stabilizers for lyophilized vaccines |
| JP2000507963A (ja) * | 1996-12-20 | 2000-06-27 | メルク エンド カンパニー インコーポレーテッド | 凍結乾燥ワクチン用安定剤 |
| US6210683B1 (en) * | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| CN112023057B (zh) * | 2020-10-21 | 2021-08-03 | 成都柏奥特克生物科技股份有限公司 | 疫苗保护剂 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS49109520A (de) * | 1973-02-07 | 1974-10-18 |
-
1980
- 1980-06-13 JP JP8046580A patent/JPS577423A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS49109520A (de) * | 1973-02-07 | 1974-10-18 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS577423A (en) | 1982-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100702086B1 (ko) | 동결 건조된 감독 ａ형 간염의 생 백신 및 그의 안정화제 | |
| US6231860B1 (en) | Stabilizers for live vaccines | |
| CN101679954A (zh) | 用于活的减毒病毒的方法和组合物 | |
| WO2010124428A1 (zh) | 一种不含明胶的疫苗冻干保护剂及其制备方法 | |
| CA1237076A (en) | Hepatitis b vaccine | |
| JP2002516850A (ja) | 凍結乾燥ワクチンの安定化剤 | |
| BRPI0915696B1 (pt) | Composição de vacina de rotavírus liofilizada e método de preparar a referida composição | |
| KR20090007588A (ko) | 니코틴-담체 백신 제제 | |
| AU2018236897B2 (en) | Compositions and methods for live, attenuated alphavirus formulations | |
| JPH0133449B2 (de) | ||
| JP2018162254A (ja) | トロンビン溶液及びその使用方法 | |
| US20210069318A1 (en) | VLP Stabilized Vaccine Compositions | |
| JPS6314729A (ja) | 生ワクチン用改良安定剤、その製造法およびそれを含有するワクチン | |
| JPH06234659A (ja) | 安定化生ワクチン | |
| US3186908A (en) | Calcium lactobionate stabilization of labile antigenic virus vaccine materials | |
| US11123420B2 (en) | Stable live attenuated recombinant dengue vaccine | |
| JP2000507963A (ja) | 凍結乾燥ワクチン用安定剤 | |
| Webb et al. | Argentine and Bolivian hemorrhagic fevers (South American hemorrhagic fevers) | |
| CA2424863A1 (en) | Vaccine composition and stabilisation method | |
| Berge et al. | Preservation of enteroviruses by freeze-drying | |
| PT87388B (pt) | Processo para a preparacao de uma vacina viva de virus herpes liofilizada e estavel | |
| SU660389A1 (ru) | Способ получени вакцины против клещевого энцефелита | |
| CA1183083A (en) | Herpes virus vaccine | |
| JPS585169B2 (ja) | ウイルス性混合生ワクチンの製法 | |
| KR20030025480A (ko) | 약독화 수두 생바이러스 백신용 무단백질 안정화제 |