JPH01230512A - Hair growth promoter - Google Patents

Abstract

PURPOSE: To obtain a hair growth accelerator having high safety and a validity higher than the usual same kind of medicine using a natural crude drug by blending at least Thujae orientalis folium et ramulus, Polygoni multiflori radix, Angelica radix and Ligustrum lucidum as active components. CONSTITUTION: This hair growth accelerator having excellent safety to curing of alopecia compelled to use for a long period of time and exhibiting an excellent curing effect equivalent to a market-sold carpronium chloride by blending preferably respective 1-3 pts.wt. of a crude drug or its extract (a weight ratio of the crude drug itself and an extract is reduced to a crude drug weight), especially an extract by a water-containing alcohol selected from Thujae orientalis folium et ramulus, Polygoni multiflori radix, Angelica radix and Ligustrum lucidum, and further Psoralea corylifolia as active components.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Field of Application) The present invention relates to a hair growth promoter of a new Chinese medicine (also referred to as Chinese medicine or Chinese herbal prescription). More specifically, the present invention relates to a hair growth promoter comprising at least Cypress leaves, Heshu Karasu, Dongki, and Onnako, or a bone grafting fat added thereto.

(Prior Art) Since ancient times, there have been many attempts to obtain hair growth and hair growth-promoting substances from natural animals, minerals, and plants. In addition, there are countless patent documents featuring established Japanese and Chinese herbal medicines (including herbal medicines for alopecia areata) as well as hair growth and hair growth-promoting substances. However, there are few attempts to treat alopecia with new Chinese herbal medicine.

Kampo attempts to organically and comprehensively treat an individual's disease by administering a combination of several Japanese and Chinese herbal medicines, and can be said to be a treatment-oriented medicine based on clinical experience. The desired comprehensive synergistic effect cannot be expected just because it has the desired effect. However, some prescriptions for alopecia have been known since ancient times. For example, according to Kampo Medical Medicine, 318-319 (1st edition published by Nanzando on January 15, 1969), in the section on 2-round alopecia, Taisaikoto, Shosaikoto, Saikokaryukotsuoyaito, It includes prescriptions for internal and external use such as Keishikaryukotsu Oobito, Jin-Oyo-Shintan, Bofu-dō-san, Hōwara-san, and Shiun-go, and it is stated that they should be used depending on the symptoms. Incidentally, the composition of these Chinese herbs is as follows.

0) Daisaikoyu Saiko6. Half summer 4. Concubine 4. Huang Ling 3. Xun medicine 3. 3 degrees of fire, 1-2. Inuzatsu 3゜(2) Shosaikoyu Saiko7. Half summer 5. Concubine 4. Yellow mustard 3. 31 large jujube, 3 carrots, 2 licorice (3) Saikoka Ryukotsu Okaito Saiko 5. Half summer 4. Warrior 3. Katsura 3. Huang Ling 2.5. Ikubishi 2
．． 5. Daito 2.59 carrots 2.5. Keel 2.5. Oyster 2.
5. Fire Zake 1 (4) Keizhika Ryukotsu Oyster Tang Guizhigou (Guizhi 4. Xun Yaku 4. Daijutsu 4. Fresh form 4. Licorice 2) with 3 each of Keizhi and Oyaku added.

(5) 3 each of Shinyōyo Shindandōki, Yoshu, Takuyaku, Tenma, Onikatsu, Jukudaihuang, Mokkou, and Rabbit Thread. Tsukuda, thin cargo, raw form.

1.2 each of Aoki, Windproof, and Ephedra. Dog Yellow, Glauber's Salt 1.5° each Kikyo, Chalk 1. Licorice, 1 yellow strawberry, 2 each. Talcstone 3 (7) Bald Sensan (Asada Okikata) Yugi 2. Sulfur 4. Akeiwa 1. A liniment made by putting 3 pieces of rhubarb into a clam shell and turning it into a slurry with vinegar (8) Shiunko sesame oil 1000. Return 100. Purple root 100. yellow wax 3
80° pork fat 25 Also, practical dermatology (practical dermatology).

278-279 (1981) (published by Guangdong Science and Technology Publishing House) describes the experience method consisting of 9 each of Danggui, Heshouwu, and Xiangziren as a Chinese medicine for the treatment of baldness disease (ALOPECIA). Maru (Ikuyu Maru; Toki 3゜Yoman 24. Tenma 2
．． Onikatsu 2. Jukuchi 6. Mokko 2. 6).

In addition, the Tokoe Chinese Medicine Journal (Jinjie Chinese Medicine Yoshi).

Volume 8, 11th, 14 (1965) mainly includes oral medicines and preparations for the treatment of alopecia areata.
Alternatively, it is reported that good results have been obtained when applied to alopecia using a mixture of Onna Sadako and Early Lotus Grass depending on the medical condition.

On the other hand, the second herbal medicine used as the active ingredient of the present invention is Nukuhakuyo (Nukuhakuyo).
) is a species of Cypressaceae [BioLa Orien
talis (L,) gndl, refers to the young branches and leaves of the coryza, and cools the blood. Stop bleeding. Leave the wind temperature.

It has the effect of dispersing tumor toxins, mainly for hematemesis.

It is said to cure bleeding, urinary bleeding, hematorrhea, etc.

It is also known that its alcohol solution is effective in treating baldness. [See Dictionary of Chinese Medicine, page 21. Published December 10, 1985 (Shogakukan)].

Kashinira, also known as Shu, is a member of the Polygonaceae family.
num mulLiflorum Thumb), which has the efficacy of replenishing the liver, benefiting the kidneys, nourishing the blood, and eliminating wind, and is said to cure problems such as liver-kidney scrotum and premature graying of hair. Also.

As mentioned above, it is known to have been used as one of the ingredients in Chinese herbal medicine for the treatment of alopecia areata. In addition, a patent application has recently been filed regarding the use of this hair growth promoter (Japanese Patent Application Laid-Open No. 59-55815).

In addition, Touki (Angki) is a member of the Umbelliferae family.
elica, 5inensis (Oliv) Di
els) rootless, replenishes blood and soothes blood. Adjusts the meridian and relieves pain. Moisturizes dryness and smooths the intestines. It is said to be effective in curing menstrual irregularities, cessation of menstruation, etc. Note that in Japan, ``tōki'' is often used as ``tōki'' or ``Hokkai toki.''

Female Sadako (Jiteishi) is a rat mochi (L) of the Oleaceae family.
The fruit of Lrum lucidum Alk) supplements the liver and kidneys and strengthens the hips and knees. It has the efficacy of
It is said to cure symptoms such as yin-deficient internal fever, eye blooms, tinnitus, IM knee acid softening, and whitening of beards and hair. In addition, as mentioned above, it is known that it is added to nejichi, hekukarasu, along with early lotus, depending on the condition of alopecia areata.

Furthermore, Japanese Patent Application Laid-Open No. 62-99318 discloses that extracts of female staghorn are useful as a hair nourishing agent.

In addition, bone fat (hokoshi) is a component of the leguminous family Dutchby (
Psorale eorylifolim L, )
The fruit is said to be effective in replenishing the kidneys and supporting yang.

It is known to be effective in treating renal failure and ablation. It is also known that an injection of this bone grafting fat has been used to treat baldness (alopecia); see Encyclopedia of Traditional Chinese Medicine (cited above), p. 2423].

Blank space below (problems to be solved by the invention) As is well known, the treatment of alopecia requires long-term use, so natural herbal medicines, their extracts, or Chinese herbal medicines, which are highly safe, have to be reconsidered. , Cosmetics etc. have been added [
It is used.

However, natural herbal medicines and their extracts, which are said to have hair growth and hair growth effects, have only a mild therapeutic effect, and the above-mentioned Chinese medicine, which is based on organic and comprehensive treatment, especially those with experience, such as Ikkamigan, etc. Even so, the therapeutic effect is inferior to carpronium chloride, which is the main ingredient in commercially available hair growth agents, and the reality is that until now there have been no natural herbal medicines or Chinese herbal hair growth promoters that are comparable to carpronium chloride.

(Solution Means) As a result of intensive research into the development of a hair growth promoter that is highly safe and comparable to commercially available hair growth agents containing carpronium chloride as its main ingredient, the present inventors have found that at least The present inventors discovered that a Chinese herbal medicine consisting of ``Sadako'' and ``Sadako'' and a Chinese herbal medicine containing bone fat added thereto exhibits an excellent therapeutic effect on alopecia, and thus completed the present invention.

In other words, the first invention of the two applications comprises a hair growth promoter containing at least Physifolia foliage, Heshukarasu, Dangki, and Onna Teiko as active ingredients, and the second invention of the two applications comprises at least Physifolia foliage, Heshukarasu, Dangki, and Onna Teiko as active ingredients. .

The object of the present invention is to provide a hair growth promoter containing Sadako Toki and bone fat as active ingredients, and to provide these hair growth promoters.

Below, one configuration of the present invention will be explained in detail.

(active ingredient) The Chinese herbal medicine of the present invention is lateral oak leaf and heshouwu.

For Toki 2nd daughter Sadako and supplementary bone fat, use the ones mentioned above.

In the present invention, these terms are not limited only to crude drugs themselves, but also include infusions, decoctions,
Alternatively, infusions, decoctions, tinctures, and liquid extracts are produced by further concentrating part or all of the infusion, or by drying the ammonium.

It also includes extracts (hereinafter these extracts are simply referred to as extracted extracts) and the chemical substances themselves that are contained in crude drugs and exert their main effects.

Infusion or decoction (hereinafter referred to simply as extraction) of the extract can be done using water, alcohol such as methanol, ethanol, isopropanol, etc.

Ether, dioxane, tetrahydrofuran.

Acetone, methyl ethyl ketone (2-butanone).

Benzene, toluene, xylene, ethyl acetate.

Organic solvents such as dichloromethane, dichloroethane, chloroform, carbon tetrachloride, methoxyethanol, ethoxyethanol, etc., and mixed solvents thereof (・ are solvents such as alkaline water, or sesame oil.

It is carried out using vegetable oil such as soybean oil, and may be any of cold soaking, Percolay silane, and hot soaking. The leaching process is 12-962-9 in case of cold immersion or percolation.
In the case of about 6 hours, it varies depending on the type of solvent used and the temperature.

It is advantageous to carry out the reaction preferably at a temperature close to the reflux temperature of the solvent for about 0.5 to 24 hours.

In particular, the extract of the present invention is preferably a tincture, liquid extract, or extract leached with hydrous alcohol.

The proportion of the herbal medicine in the Chinese medicine (prescription) of the present invention is as described in the Examples: 1 part each of Side Oak Leaf, Heshu Karasu, Dangki, and Onna Teiko (hereinafter, this prescription will be referred to as No. 1 prescription).

Or 1 side oak leaf, 1 chou crow, 1 female Sadako of Toki, and 1 each of bone fat.
(hereinafter referred to as No. 2 prescription) is the most suitable, but depending on the degree or situation of the disease or the constitution of the subject to be administered.
The proportion of each herbal medicine can be increased or decreased depending on various variables such as age. Therefore, the proportion of herbal medicines may be any proportion as long as it can effectively exhibit the hair growth promoting effect, but it is particularly preferable to select the proportion within the range of 1 to 3 parts of each of these herbal medicines.

The above ratio is a specified weight ratio of the crude drug itself, and when blending the crude drug itself and extracting the entire herbal medicine, it can be left as is, but when blending with extracted extract or chemical substances, it is converted to the weight of the crude drug. It is preferable to set the prescription ratio by

As is well known, the essential oil of Cypress leaves contains tsene, thujone, fenchone, pinene, and caryophyllene, and the essential oil of Cypress leaves contains aromatic compounds such as aromapunthrin, quercetin, myricetin, cypress flavone, and anthraquine. , Voyts, tannins, resins, vitamin C, etc. In addition, anthraquinones such as clinphanol, emodin, rhein, phosdione, chrysophal, anthrone, etc.

Contains starch, fat, lecithin, etc.

From Toki, ferulic acid, succinic acid, nicotinic acid, uracil, etc. are obtained from the water-soluble part, 7 thallides such as butyrizo/phthalide, ligus tylide, etc. are obtained from the petroleum ether part,
Amino acids such as adenyl, lolin and 13fiII have been isolated, as well as large amounts of sucrose and vitamin Bl! , vitamin A and its related substances have also been obtained. Furthermore, n-butyl phthalide, coumarins, sesquiterpenes, biotin, etc. have also been isolated from Japanese-produced Okina Toki and Hokkai Toki.

Female Sadako contains oleanolic acid, acetyloleanolic acid, mannitol, crucose, palmitic acid, stearic acid, ursolic acid, etc.

In addition, the fruit contains 20% essential oil in bone fat.

Organic acid (C4°H4s O+.), a type of methyl glycoside.

Contains alkali-soluble resin, non-volatile terpene oil, and saponin, and the 70 seeds contain coumarins such as psoralen and isopnoralen, flavonoids such as babaquin, pavaquinin and invapaquinin, chalcones such as babachalcone and isobabachalcone, and monoterpene phenol derivatives. Bakkior,
Other essential oils and resins2. It is known to contain fats and fatty oils.

The present invention also includes formulations that are effective for promoting hair growth and include combinations of 1f3i or more of the above chemical substances, which correspond to the combinations of the above herbal medicines.

On the other hand, as is clear from the hair growth test and clinical test in the Examples, the word ``hair growth promotion'' of the present invention refers to the term ``hair growth promotion'' of the present invention.
Prescription) is hair growth 2 hair growth.

It has been found to be effective for stopping hair loss, reducing seborrhea, and itching.It not only has the effect of promoting hair growth in the narrow sense, but also has various effects such as hair growth, hair growth, hair growth, and prevention and termination of hair loss. It should also be understood as an inclusive term. Therefore, the hair growth promoter of the present invention can be used as a preventive and therapeutic agent for various alopecias such as alopecia areata, androgenetic alopecia, and seborrheic alopecia.

The hair growth promoter of the present invention may be combined with other hair growth promoters in addition to the above-mentioned Chinese herbal medicine (prescription) within a range that does not impair the main effect of the Chinese herbal medicine (prescription), preferably in order to give a synergistic effect to the main effect. does not prevent the addition of Such substances include peripheral vasodilators such as calguronium chloride;
Hinokitiol, benzalkonium chloride, benzethonium chloride, chlorhexidine and its salts, undecylenic acid, hexachlorophene.

Phenol, cetylpyridinium chloride.

antibacterial agents such as trichlorocarbanilide and bitionol;
Vitamin E and its derivatives, pantothenic acid and its derivatives,
Vitamins such as vitamin B (vitamin C is contained in cypress leaves, vitamins A and B are contained in toki, and biotin is contained in toki grown in Japan (although you may add more)
.

Amino acid EC amino acids such as serine and methionine are also included in Toki, but you can also add more), skin function enhancers such as cephalanthine and photosensitive pigments, 2 female hormones, glycyrrhizin and its salts, etc. Anti-inflammatory agents, antipruritics such as glycyrrhetinic acid and its esters, antihistamines such as diphenhydramine and its salts, chlorpheniramine salts, keratin emollients such as salicylic acid and resorcinol, niche/scalp acids such as benzyl acid and panilamide nonylic acid. In addition to chemical substances such as stimulants, various testosterone-5α-ligutase inhibitors, high-grade fat-acid preventers, and glycerides of higher fatty acids (including odd-numbered carbon chains), Chinese herbal medicine (prescription) that has been a hair growth promoter since ancient times. Netsuchi, saiko, and yoman are used as herbal medicines.

Two raw carrots, a shield, an oyster, a cannabis plant, a devil, and a quince.

Examples include rabbit thread, licorice, and their extracts.

(Pharmacological effect) The pharmacological effect test results of the present invention are shown below.

Preparation Example 1 (Formulation No. 1) Cut the side oak leaves into 10 cm long pieces, and cut the leaves into pieces with a thickness of 0.5 cm.
5 em Weighed 270 g of each K-cut female Sadako as they were.

To this was added 4,500 cal of 75% aqueous ethanol, cooled at room temperature for 48 hours, then heated under reflux for 4 hours, filtered the leachate, and extracted the extract (hereinafter referred to as the stock solution) at 2,70 cal.
I got 0a+Z.

The stock solution was then concentrated and lyophilized to obtain the dry extract 115
I got g.

For the pharmacological tests and clinical trials, the stock solution No. ethanol solution (diluted with stock solution Nia 5% aqueous ethanol = 1:1) was used.

vI4 Preparation Example 2 (Prescription No. 2) Cut the oak leaves on the side into 10 cm long pieces.9.
Cut into 5cm pieces and leave the 1st daughter Sadako and bone fat intact for 270 yen each.
g, and treated in the same manner as in Preparation Example 1 to obtain a stock solution of 2.500 g.
m1 was obtained. This stock solution was pressed in the same manner as in Preparation Example 1 to obtain 111 g of dry extract powder.

(Pharmacological test) Table 1 shows the results of the mouse hair growth test, and Table 2 shows the results of the guinea pig hair growth test.

Table 2 (Mouse) Table 2 (Guinea pig) (Clinical trial) 17 patients (15 to 58 years old) presenting with alopecia areata
(9 male patients aged 58 years old, 8 female patients aged 20 to 43 years old), and 3 patients aged 22 to 30 years old presenting with androgenetic alopecia.
Male patient 6, aged 24 to 50, presenting with seborrheic alopecia
A total of 26 cases were targeted, and these patients were given 1 ml-1.5 rnl of the undiluted ethanol solution of Prescription No. 1, applied to the affected area 2 to 3 times a day for 3 months, and the condition of the affected area was observed. The hair promoting effect was determined.

Significant effect (＋＋＋　)　Black hair starts to grow all over.

Quite effective (++) Black hair grows in some areas.

Effective (+) Alopecia areata; Thin hair begins to grow.

Seborrhea: Decreased seborrhea. Pain relief.

Stopped hair loss or thinning hair begins to grow.

The effectiveness was determined using four levels of ineffective (-), and those above effective were judged to be effective.

The results are shown in Table 3.

Table 3 Also, during this clinical trial, no side effects such as redness or itching were observed.

The above clinical trial results are comparable to commercially available carpronium, and there are no side effects observed, so it is highly safe.

(Effects of the invention, administration method, and dosage) As is clear from the above, 5. The present invention is superior in effectiveness to hair growth promoters using conventional natural herbal medicines.
Moreover, it has a particularly remarkable effect in that it can provide a hair growth promoter with excellent safety.

The hair growth promoter of the present invention is an exudate as described above.

Alternatively, the ethanol diluted solution of the infusion is suitable for use as a liniment, but general Chinese herbal prescription preparations, i.e.
Detergents, decoctions, tinctures, extracts.

Liquid extracts, elixirs, syrups, ointments.

It can be made into internal or external preparations such as cream preparations. In addition, hair tonics, hair tonics, and hair lotions can be made using the traditional Chinese herbal formula of the present invention.

It can also be blended into hair cosmetics such as hair creams, shampoos and conditioners to produce medicinal cosmetics.

These various forms of drugs or cosmeceuticals are prepared by conventional methods by appropriately selecting additives that are commonly used in the product. Solvents such as ethanol and hydrous innopropateol.

Olive oil, sesame oil, soybean oil, corn oil.

Vegetable oils such as rapeseed oil, cottonseed oil, camellia oil, and peanut oil;
Oils and fats such as vegetable fats such as Japanese wax, cacao butter, and coconut oil, waxes such as carnauba wax, beeswax, spermaceti wax, and lanolin, and liquid paraffin.

Hydrocarbons such as squalane and petrolatum, lactic acid, succinic acid, tartaric acid, citric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, lylunic acid.

Fatty acids such as ricinoleic acid and behenic acid, higher alcohols such as cetyl alcohol and stearyl alcohol,
Glycerin, polyglycerin, erylene glycol, propylene glycol, polyhydric alcohols such as 1,3-butanediol, fatty acid glycerin ester, sucrose fatty acid ester, sorbitan fatty acid ester, polyoxyethylene lupicone fatty acid ester, polyoxyethylene Sorvit fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil fatty acid ester, polyglycerin fatty acid ester.

Surfactants such as N1% chain acyl-L-glutamic acid, higher alcohol diester, N-long-term acyl-L-f rutamic acid polyoxyethylene higher alcohol ether diester, dibasic acid diester such as adipic acid diester, sepatic acid diester, Arabic Rubber, guar gum, carrageenan, pectin, agar (unprocessed), mannan,
Tragacanth gum, xanthan gum, dextrin, gelatin, gluten, casein, collagen, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose.

Hydroxypropyl methyl cellulose, carboxy methyl cellulose and its salts, alginic acid, propylene glycol alginate, polyvinyl alcohol.

Polyvinylpyrrolidone, carboxyvinyl polymer.

Water-soluble polymers such as polyacrylic acid and its salts, polyethylene glycol (macrogol), methyl vinyl ether maleic anhydride copolymer, cornstarch, wheat f
Starches such as starch and barley starch, and silica
#L Natural or synthetic sugars such as lactose, glucose, mannitol, palatinose, calcium sulfate, calcium phosphate, precipitated calcium carbonate, sodium chloride, light anhydrous silicic acid, magnesium stearate, Merck, synthetic aluminum silicate, magnesium oxide, titanium oxide , inorganic substances such as dried aluminum hydroxide gel, other cooling agents such as menthol, preservatives such as methylparaben and ethylparaben, nordihydroguaiaretic acid.

DMA, B) IT, antioxidants such as propyl gallate.

Other commonly used colorants, fragrances, etc. may be used.

The dosage varies depending on the patient's age, symptoms, administration route, etc., but in the case of external liquid preparations, it is f ral ~ 1.5 per day.
It is preferable to apply this 1 to 5 times a day for one month or more.

Patent applicant Osamu Hanakawa (and one other person) Private patent attorney Seiya Fujino

Claims (1)

[Scope of Claims] 1. A hair growth promoter containing at least cypress leaves, heshukarasu, dōki, and yadako as active ingredients. 2. 1 to 3 parts of each of cypress foliage, heshukarasu, dōki, and yoshiko. Claim 1 or 2, wherein one or more of the prescription ingredients comprising the hair growth promoter 3, cypress leaf, heshukarasu, dangki, and female pedagogia according to claim 1 is an extract. The hair growth promoter 4 described in Claims 1 to 3 is an extract of cypress leaf, heshugarasu, dangki, and maidenko with hydrous alcohol.
Hair growth promoter 5 according to any one of the above, hair growth promoter 6 containing at least Cypress leaf, Hekhukarasu, Toki, Mesadako, and bone fat as active ingredients, Cypress leaf, Heshukarasu, Toki, Mesadako, and 1 of the prescription ingredients consisting of the hair growth promoter 7 according to claim 5, which contains bone fat in the range of 1 to 3 parts, side oak leaf, heshukarasu, dangki, women's fat, and bone fat. The hair growth promoter 8 of claim 5 or 6, in which the species or more is an extracted extract, the hair growth promoter 8 of the patent claim, which is an extract of cypress leaf, heshu karasu, dangki, female pedagogium, and bone fat extracted with hydroalcohol. Hair growth promoter according to any one of items 5 to 7.