KR20020025358A - Composition for growing hair and method of preparation thereof - Google Patents
Composition for growing hair and method of preparation thereof Download PDFInfo
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- KR20020025358A KR20020025358A KR1020000057086A KR20000057086A KR20020025358A KR 20020025358 A KR20020025358 A KR 20020025358A KR 1020000057086 A KR1020000057086 A KR 1020000057086A KR 20000057086 A KR20000057086 A KR 20000057086A KR 20020025358 A KR20020025358 A KR 20020025358A
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- dry weight
- mixture
- dry
- powder
- hair
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/20—Ingredients acting on or related to the structure
- A23V2200/21—Binding agent
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
Description
본 발명은 발모 조성물 및 이의 제조 방법에 관한 것으로, 좀 더 자세하게는 감태 0.1∼10 건조중량%, 적하수오 1∼10 건조중량%, 대추 5∼30 건조중량%, 호두 10∼30 건조중량%, 검은 깨 10∼30 건조중량%, 상심자 1∼10 건조중량%, 및 식용 바인더 5∼25 중량%로 이루어진 발모 조성물 및 이의 제조 방법에 관한 것이다.The present invention relates to a hair regrowth composition and a method for producing the same, more specifically 0.1 to 10% dry weight of Ecklonia cava, 1 to 10% dry weight dripping water, 5-30% dry weight of jujube, 10-30% dry weight of walnut, It relates to a hair regrowth composition consisting of 10 to 30% by weight of black sesame seeds, 1 to 10% by weight of cores, and 5 to 25% by weight of an edible binder, and a method for producing the same.
일반적으로 사람의 두발이 탈모되는 원인은 유전적 요인, 노화의 진행, 약물 복용, 방사선 치료, 및 중병 후 스트레스 등을 들 수 있다. 생화학적 및 생리학적 관점에서 탈모 현상은 남성호르몬의 과다 활동, 두피 혈액순환의 문제, 및 모발대사에 필수적인 영양소의 결핍의 세가지 주요 원인에 의한 것이라고 알려져있다. 상기 세가지 요인들이 단독으로도 탈모를 유발할 수 있지만, 탈모요인들이 복합되어 상승작용을 일으키게 되면 탈모증이 가속화되고 증상이 심해지게 된다. 특히, 유전적 요인 또는 후천적 특수조건으로 인하여 남성호르몬의 생성, 변화, 인식 및 신호전달 과정이 과도하게 작동하여 모낭 조직이 조기 노화되는 경향을 갖게 된다면 그렇지 않은 일반인 보다 조기에 대머리가 될 확률이 높다. 또한 유전적 요인, 노화, 서구적 고지방 식생활 및 기타 외부적 요인으로 인하여 두피의 긴장도가 쉽게 높아지거나 동맥경화증 등의 증상이 있는 경우 혈액순환 장애가 쉽게 일어나므로 원활한 모발 대사에 장애가 생긴다.In general, the causes of human hair loss include genetic factors, the progress of aging, drug use, radiation therapy, and post-stress stress. From a biochemical and physiological point of view, hair loss is known to be due to three major causes of hyperactivity of male hormones, problems with scalp blood circulation, and a lack of nutrients essential for hair metabolism. Although these three factors alone can cause hair loss, when hair loss factors are combined to cause synergy, hair loss is accelerated and symptoms become worse. In particular, if genetic factors or acquired special conditions cause the production and alteration of male hormones, recognition, and signaling overworking, hair follicle tissues tend to age prematurely, which is likely to cause premature baldness. . In addition, due to genetic factors, aging, Western high-fat diet and other external factors, the tension of the scalp is easily increased, or if there are symptoms such as arteriosclerosis, blood circulation disorders occur easily, and thus, there is a problem in smooth hair metabolism.
한편, 모발대사를 포함한 인체의 대사활동을 수행하는데 필수적인 수많은 효소들이 적절히 생성되고 정상적인 활동을 수행하기 위해서는 호르몬, 비타민, 미네랄, 필수아미노산, 및 지질 등의 영양소가 충분히 공급되어야 하며, 매우 좁은 범위의 온도 및 pH 조건의 유지가 필요하다. 하지만 인체가 과도한 체력소모, 중병, 화학요법, 및 영양불균형 등의 장기적인 스트레스에 노출될 경우 인체는 생존을 위하여 상기 대사 요소들을 좀 더 필수적인 조직에 집중함으로써 항상성을 유지하려고 하는 경향을 갖게 되며 이 때 생존 문제에 있어서 우선 순위가 떨어지는 두발 생성 작용이 둔화됨에 따라 탈모와 발모의 균형이 탈모 쪽으로 진행되게 된다. 이러한 영양소적인 요인은 원형 탈모증이나, 방사선 치료, 및 항암 치료 후에 탈모를 일으키게 되며 유전적 요인 및 노화에 의한 탈모를 가속시킨다.On the other hand, a number of enzymes essential for the human body's metabolic activities, including hair metabolism, must be adequately supplied and sufficient nutrients such as hormones, vitamins, minerals, essential amino acids, and lipids are needed to perform normal activities. Maintenance of temperature and pH conditions is necessary. However, when the body is exposed to long-term stresses such as excessive physical dissipation, serious illness, chemotherapy, and nutritional imbalance, the body tends to maintain homeostasis by concentrating the metabolic elements in more essential tissues for survival. As the hair production action, which has a lower priority in terms of survival, slows down, the balance between hair loss and hair growth progresses toward hair loss. These nutrient factors cause alopecia areata, hair loss after radiation treatment, and chemotherapy and accelerate hair loss due to genetic factors and aging.
상기 요인들에 의해 유발된 대머리의 치료를 위해 현재까지 다양한 시도가 이루어져 왔는데, 먼저 외과적인 방법으로는 두피피판술, 탈모부위축소술, 및 조직확장술에 의한 두피성형술과 최근에 발전된 자가모발 이식술 등이 있다. 상기의 외과적 방법은 비록 그 효과면에서는 우수하더라도 수술에 대한 환자의 경제적, 정신적 부담이 매우 크므로 널리 사용되기 어렵다는 단점을 가지고 있다.Various attempts have been made to treat baldness caused by the above factors. First, surgical methods include scalp scalp, alopecia reduction, and scleroplasty by histopathoplasty and recently developed autologous hair transplantation. . Although the surgical method is excellent in terms of its effectiveness, it has a disadvantage in that it is difficult to be widely used because the economic and mental burden on the patient is very large.
이에 다양한 외용제가 사용되고 있는데, 미국 FDA의 공인을 받은 미녹시딜(Minoxidil)은 모세혈관 확장 기능이 있어 두피에 바름으로써 탈모를 방지하지만, 매일 2회씩 지속적으로 발라야하고, 3∼4시간 동안 약제가 두피에 머무르도록 해야만 어느 정도 효과가 나타나는 등 불편할 뿐 아니라, 그에 상응하는 효과면에서도 미미하고, 가려움증, 자극 등의 부작용이 나타나는 실정이다. FDA의 공인을 받은 내복약인 피나스테라이드(finasteride)는 탈모를 유발하는 남성 호르몬인 DHT(5α-dihydrotestosterone) 생성 억제 작용을 갖고 있으며, 6개월에서 1년 정도 복용시 발모 또는 탈모억제 효과가 나타나는 것으로 알려져 있지만 복용을 중단하면 2개월 안에 원상태로 돌아가는 문제점이 있었다. 또한, 부작용으로는 성욕감퇴, 발기부전 등의 성기능 감퇴 등을 들 수 있으며 여성은 기형아 출산 위험이 있기 때문에 복용해서는 안되는 것으로 알려져 있다.Various external preparations are used. Minoxidil, which is certified by the US FDA, has capillary expansion function to prevent hair loss by applying it to the scalp, but it must be applied twice a day continuously for 3 to 4 hours. It is not only inconvenient to have a certain effect to stay, but also insignificant in terms of the corresponding effects, and it appears that side effects such as itching and irritation appear. The FDA-approved oral drug, finasteride, has the effect of inhibiting the production of the male hormone, DHT (5α-dihydrotestosterone), which causes hair loss. There was a problem returning to the original state within two months if you stop taking. In addition, side effects include decreased sexual function, such as decreased libido, erectile dysfunction, etc. Women are known to not take because of the risk of birth defects.
생약성분의 추출물을 이용하여 두피에 바르거나 복용함으로써 발모를 촉진시키려는 시도 또한 많이 있었는데, 난초과 식물의 추출물을 이용하는 경우(대한민국특허 제0157667호), 웅지와 만형자를 이용하는 경우(대한민국 특허 제0161338호), 만병초 엑기스를 유효성분으로 사용하는 경우(한국특허공개 제91 - 106호), 소나무잎 추출물을 이용한 발모촉진제(한국특허공개 제96 - 40346호), 누에 등을 이용한 발모촉진제(한국특허공개 제 90-2757호), 오갈피 뿌리, 단너삼 뿌리, 적하수오 뿌리, 부채마, 및 메밀을 유효성분으로 하는 발모 육모제(한국공개 특2000-24499), 반하, 정향, 복분자, 산초, 만형자, 단삼 및 백자인을 이용하는 경우(대한민국 특허 제259037), 원자마, 잠종, 잠태, 잠사, 및 번데기를 약 200℃에서 15분 정도 가열하여 얻은 기름을 사용하는 경우 (한국공개특허 제90-2757호), 인삼, 황기, 당귀, 하수오, 호도, 복분자, 생지황, 보골지, 송채, 단삼, 홍화, 여정실 혼합 추출물을 사용하는 경우(한국공개특허 제90-13934호), 원자마(누에나방), 잠종(누에씨), 번데기(누에), 검은깨, 다시마, 참깨, 및 호두알을 고압 고온 추출하여 사용하는 경우(한국공개특허 제90-5952호), 녹두분, 대두분, 흑미분, 들깨분, 참깨분, 호두분, 김분, 홍합분, 굴분, 멸치분, 미역분, 다시마분, 효모농축액 또는 이의 건조분을 혼합 사용하는 경우(대한민국 특허 제0260673호), 사상자, 솔잎, 및 원자마를 사용하는 경우(한국공개특허 제90-002757호), 구기자 열매, 뿌리, 가지(줄기), 잎, 순, 꽃 및 강냉이 수염을 사용하는 경우(한국공개특허 특2000-36534호) 등이 공개된 바 있으나 그 작용 원리가 명확하지 않으며 효능이 충분히 검증되지 않은 실정이다.Many attempts have been made to promote hair growth by applying or taking herbal medicines to the scalp, using orchid plant extracts (Korean Patent No. 0157667), and using wormwood and mandrel (Korean Patent No. 0161338). ), In the case of using Manbyeongcho extract as an active ingredient (Korean Patent Publication No. 91-106), hair growth promoter using pine leaf extract (Korean Patent Publication No. 96-40346), hair growth promoter using silkworms (Korea Patent Publication) No. 90-2757), Ogalpi Root, Danner Ginseng Root, Red Sewage Root, Fanzama, and Hair Growth Hair Loss Agent with Buckwheat (Korean Patent Application Laid-Open No. 2000-24499), Half, Clove, Bokbunja, Sancho, Manza, Dansam And using white porcelain (Korean Patent No. 259037), using oil obtained by heating atomic hemp, latent species, latent fetus, silkworm, and chrysalis at about 200 ° C. for about 15 minutes. Patent No. 90-2757), Ginseng, Astragalus, Angelica, Shouo, Hodo, Bokbunja, Raw Yellow Sulfur, Bogolji, Songchae, Sweet Ginseng, Safflower, Journey Chamber Mixed Extract (Korea Patent Publication No. 90-13934), Won When high-temperature, high-temperature extraction of yam, silkworm moth, silkworm seed, chrysalis, black sesame, kelp, sesame, and walnut eggs is used (Korean Patent Publication No. 90-5952), mung bean flour, soybean meal , Black powder, perilla powder, sesame powder, walnut powder, seaweed powder, mussel powder, oyster powder, anchovy powder, seaweed powder, kelp powder, yeast concentrate or dry powder thereof (Korean Patent No. 0260673), casualties, When using pine needles and atomic hemp (Korea Patent Publication No. 90-002757), when using goji berries, roots, branches (stems), leaves, shoots, flowers and horseradish whiskers (Korea Patent Publication No. 2000-36534) ), But the principle of its operation is not clear and its efficacy has not been fully verified.
결론적으로, 전술한 공지의 방법 및 발모제들은 탈모환자에게 경제적 부담 및 고통을 주거나 부작용을 유발하고, 효과가 일시적이거나 또는 단편적인 약리학적 기작 만을 사용하거나, 작용 원리가 모호하고 효능이 충분히 검증되지 않는 등의 문제점을 가지고 있어서, 효과가 보다 뚜렷하고 지속적이며, 부작용이 없고 복용이 간편한 탈모제에 대한 요구가 증대되고 있는 실정이다.In conclusion, the above-mentioned known methods and hair regrowth agents cause economic burden and pain or cause side effects for alopecia patients, use only temporary or fragmentary pharmacological mechanisms, or are vague in principle of action and insufficient in efficacy. There is a problem, such as, the effect is more clear and persistent, there is no side effect and the need for a hair loss agent is easy to take the situation is increasing.
이에 본 발명자들이 광범위한 연구를 수행한 결과, 감태, 적하수오, 대추, 호두, 검은 깨, 및 상심자 등을 사용하여 제조한 조성물이 탈모 방지 및 발모 및 양모에 탁월한 효과가 있음을 발견하였으며, 본 발명은 이에 기초하여 완성되었다.As a result of extensive research by the present inventors, the inventors have found that the composition prepared using Ecklonia cava, drizzle, jujube, walnut, black sesame seeds, and greens has excellent effects on hair loss prevention and hair growth and wool. The invention has been completed based on this.
따라서, 본 발명의 목적은 효과적으로 탈모를 방지하고 발모를 촉진하며 그 효과가 지속되는 발모 조성물을 제공하는데 있다.Accordingly, an object of the present invention is to provide a hair growth composition that effectively prevents hair loss, promotes hair growth, and sustains the effect.
본 발명의 다른 목적은 효과적으로 탈모를 방지하고 발모를 촉진하며 그 효과가 지속되게 하는 발모 조성물의 제조방법을 제공하는데 있다.Another object of the present invention is to provide a method for preparing a hair growth composition that effectively prevents hair loss, promotes hair growth, and maintains the effect thereof.
상기 목적을 달성하기 위한 본 발명의 발모 조성물은 감태 0.1∼10 건조중량%, 적하수오 1∼10 건조중량%, 대추 5∼30 건조중량%, 호두 10∼30 건조중량%, 검은 깨 10∼30 건조중량%, 상심자 1∼10 건조중량%, 및 식용 바인더 5∼25 중량%로 이루어진다.Hair growth composition of the present invention for achieving the above object is 0.1-10 dry weight% Ecklonia cava, 1-10 dry weight% dripping water, 5-30 dry weight% jujube, walnut 10-30 dry weight%, black sesame seeds 10-30 It consists of dry weight%, core 1 to 10 weight%, and 5-25 weight% of an edible binder.
상기 다른 목적을 달성하기 위한 본 발명의 발모 조성물의 제조방법은 감태 0.1∼10 건조중량%, 적하수오 1∼10 건조중량%, 대추 5∼30 건조중량%, 호두 10∼30 건조중량%, 검은 깨 10∼30 건조중량%, 및 상심자 1∼10 건조중량%이 골고루 혼합된 제1혼합물을 제공하는 단계;The method for producing the hair regrowth composition of the present invention for achieving the above another object is 0.1-10 dry weight% of Ecklonia cava, 1-10 dry weight% of dripping water, 5-30 dry weight% of jujube, 10-30 dry weight of walnuts, black Providing a first mixture of 10 to 30% by weight of sesame seeds and 1 to 10% by weight of sesame seeds evenly mixed;
식용 바인더 5∼25 중량%에 2∼10 배 생수를 첨가하여 식용 바인더 혼합액을 만든 다음 상기 제1혼합물과 혼합하여 제2혼합물을 제공하는 단계;Adding 2 to 10 times bottled water to 5 to 25 wt% of the edible binder to form an edible binder mixture and then mixing with the first mixture to provide a second mixture;
상기 제2혼합물을 물중탕으로 80∼98℃에서 2∼10시간 정도 가열하여 20∼50% 정도 탈수하여 발모 조성물을 얻는 단계로 이루어진다.The second mixture is heated in a water bath at 80 to 98 ° C. for 2 to 10 hours to dehydrate about 20 to 50% to obtain a hair growth composition.
이하, 본 발명을 좀 더 구체적으로 설명하면 다음과 같다.Hereinafter, the present invention will be described in more detail.
본 발명에 따른 신규의 조성물은 탈모 방지 및 발모 촉진 효과가 탁월하기 때문에 주로 발모제로 사용할 수 있다.The novel composition according to the present invention can be mainly used as a hair restorer because of its excellent hair loss prevention and hair growth promoting effect.
본 발명에 따른 신규의 조성물은 감태 0.1∼10 건조중량%, 적하수오 1∼10 건조중량%, 대추 5∼30 건조중량%, 호두 10∼30 건조중량%, 검은 깨 10∼30 건조중량%, 상심자 1∼10 건조중량%, 및 식용 바인더 5∼25 중량%로 이루어지며, 바람직하게는, 감태 0.5∼5 건조중량%, 적하수오 3∼5 건조중량%, 대추 10∼25 건조중량%, 호두 20∼25 건조중량%, 검은 깨 20∼25 건조중량%, 상심자 3∼5 건조중량%, 및 식용 바인더 10∼15 중량%로 이루어진다.The novel composition according to the present invention is 0.1-10 dry weight% of Ecklonia cava, 1-10 dry weight% of dripping water, 5-30 dry weight% of jujube, 10-30 dry weight of walnuts, 10-30 dry weight of black sesame seeds, It consists of 1 to 10% by weight of the core, and 5 to 25% by weight of the edible binder, preferably 0.5 to 5% by weight of Ecklonia cava, 3 to 5% by weight of dried drop, 10 to 25% by weight of jujube, It consists of 20-25 weight% of walnuts, 20-25 weight% of black sesame seeds, 3-5 weight% of cores, and 10-15 weight% of an edible binder.
상기 식용 바인더는 물엿, 설탕, 벌꿀, 한천, 젤라틴, 및 전분으로 이루어진 군으로 부터 적어도 하나 이상 선택되며, 이중 특히 물엿을 사용하는 것이 미각적인 이유로 바람직하고, 선택적으로 주정을 10∼50%의 중량 비율로 포함할 수 있다.The edible binder is at least one selected from the group consisting of starch syrup, sugar, honey, agar, gelatin, and starch. Of these, it is preferable to use starch syrup, particularly for taste reasons, and optionally 10 to 50% by weight of alcohol. It can be included as a ratio.
상기 성분 이외에 기타 식용 첨가제로서 방부제 등의 가공성 및 보관성을 목적으로 하여 통상적으로 식품에 사용되는 성분들이 소량 사용될 수 있다.In addition to the above ingredients, a small amount of ingredients commonly used in foods for the purpose of processability and storage properties such as preservatives as other edible additives may be used.
본 발명의 발모 조성물은 한의학적 원리 및 생화학, 생리학의 물질과학적 원리를 상호 보완적으로 사용하여 여러 성분을 적절히 배합함으로써 탈모 방지 및 발모 효과를 극대화시켰으며 다양한 형태의 탈모증에 모두 적용되도록 하였다. 한의학에서 "모발은 신장 기능에 속하며, 혈액의 영양상태의 나타남이니 혈액 기능이 왕성하면 모발이 윤택하고, 혈액 기능이 쇠퇴하면 따라서 모발도 쇠퇴하게 된다"라고 알려져 있으며(동의보감), 이러한 한의학적 견해를 바탕으로 신장과 간 기능의 활성화를 통하여 혈액이 원활하게 활동할 수 있도록 기본적인 성분 구성을 하였으며, 뿐만 아니라 현대 생화학, 생리학적 관점에서 모발 상태의 개선을 위해 필요한 요소인 1) 남성호르몬의 조절 2) 두피 혈액순환의 활성화 3) 모발대사의 필수 영양분의 풍부한 공급을 만족시키는 성분을 찾기 위하여 다양한 식용 해조류로부터 생리활성 효과를 갖는 천연 물질을 검색하고 상기 성분과 함께 사용되어 탈모 방지및 발모 촉진에 상승작용을 나타내도록 배합 가공하였다.The hair regrowth composition of the present invention maximizes the hair loss prevention and hair regrowth effect by appropriately combining various components by using the principles of oriental medicine and the material science principles of biochemistry and physiology to be applied to all types of alopecia. It is known in Korean medicine that "hair is a kidney function, and it is a nutritional state of the blood. When the blood function is strong, the hair becomes lustrous, and when the blood function declines, the hair also declines." Based on the activation of the kidneys and liver function, the basic composition of the blood for the smooth activity of the kidneys, as well as modern biochemical and physiological point of view for the improvement of hair condition 1) male hormone regulation 2) scalp Activation of blood circulation 3) Searching for natural substances with physiological activity from various edible algae to find ingredients that satisfy the abundant supply of essential nutrients for hair metabolism and used together with these ingredients to synergistically prevent hair loss and promote hair growth The compounding process was shown to show.
전술한 세가지 주요 접근 방법들 중 한의학적 견지에 따른 두피 혈액순환의 활성화 및 모발대사에 필수적인 영양분의 풍부한 공급을 위하여 본 발명에서 사용한 성분으로는 적하수오, 호두, 검은깨, 대추 및 상심자가 있다. 이들에 대한 상세한 설명은 하기에 기술한 바와 같다.Ingredients used in the present invention for the activation of the scalp blood circulation and the abundant supply of nutrients essential for hair metabolism according to the oriental medical point of view of the three main approaches described above are red sesame, walnut, black sesame, jujube and heart. Details of these are as described below.
본 발명의 기본 성분 중의 하나인 적하수오는 마디풀과(Polygonaceae) 식물인 하수오(Polygonum multiflorum Thumb.)의 괴근(塊根)으로서 주로 한방에서 간과 신의 기능의 약화로 인하여 나타나는 각종 신체적 허약 증상에 사용하는 약재로서, 간과 신을 보함으로써 간신음허 증상을 치료하여 체질개선을 유도하여 모발 대사에 적절한 혈액성분을 공급할 수 있도록 한다. 가을철에 캐내어 씻어 얇게 썰고 햇볕에 말려 그대로 쓰거나, 검은콩을 끓인 즙에 섞어 쪄서 햇볕에 말려 검게된 것을 쓰면 신장기능을 활성화 시키는데 상승효과를 나타낸다. 중국 문헌을 보면 검은콩에 대한 약용 기록이 많이 등장하는데, 이 중 '본초강목'을 살펴보면 검은콩은 신장을 다스리고 혈액을 활발히 하며 모든 독을 푼다고 나와 있다. 이렇듯 검은콩과 함께 가공하여 사용하게 되면 신장 계통의 대사 촉진에 좋고 장기관이 활발하게 움직이고 몸의 대사가 활성화되므로 체질 개선이 이루어지게 할 뿐만 아니라 발모에 필요한 필수 아미노산, 불포화 지방산 및 미네랄 등도 풍부하게 공급하게 되는 것이다.One of the basic constituents of the present invention is a drop of sesame, a polygonum multiflorum Thumb. As a liver and god, by treating the symptoms of liver deafness to induce constitution improvement to supply the appropriate blood components for hair metabolism. Catch and wash thinly in autumn, dry it in the sun and use it as it is, or mix it with boiled juice and mix it with boiled black juice in the sun to activate the kidney function. Chinese literature shows a lot of medicinal records for black beans, among which, the `` herbaceous cortex '' shows that black beans control the kidneys, activate the blood, and detoxify all poisons. When processed together with black soybeans, it is useful for promoting metabolism of the kidney system, organ organs are actively moving, and metabolism of the body is activated, which not only improves the constitution but also provides essential amino acids, unsaturated fatty acids and minerals necessary for hair growth. Will be supplied.
본 발명의 기본 성분 중의 하나인 호두는 양질의 단백질과 소화 흡수가 잘 되는 필수 불포화지방산인 리놀렌산이 풍부하게 들어 있는데, 이는 동맥경화나 비만 및 피부 노화 등 혈액순환에 좋지 못한 육류에 포함된 지방산의 병폐를 모두 씻어주고 고쳐주는 역할을 함으로써 두피 모세혈관의 순환이 잘 되도록 하며, 모낭세포 등을 형성하는데 도움이 되는 지질성분을 공급하게 된다. 한방적으로는 신장을 도와주는 역할을 하여 간을 활성화시켜 혈액의 기능을 충실하게 한다.Walnut, one of the basic ingredients of the present invention, is rich in high-quality protein and linolenic acid, an essential unsaturated fatty acid that is easily digested and absorbed, which is a fatty acid contained in meat that is not good for blood circulation such as arteriosclerosis, obesity, and skin aging. By rinsing and repairing all the ills, the scalp capillaries circulate well and provide lipid components to help form hair follicles. Oriental medicine to help the kidneys to activate the liver to improve the function of the blood.
본 발명의 기본 성분 중의 하나인 검은깨는 참깨 종류 중에서도 한방에서 가장 약효가 높다고 인정되고 있다. 참깨에는 필수 식물성 지방인 리놀산과 리놀렌산이란 불포화지방산이 많아 혈관에 괴어있는 콜레스테롤을 녹이는 작용이 있으므로 혈관의 순환작용을 정상화시키며, 또한 메티오닌 등 필수 아미노산이 많이 들어 있어 뇌 및 모발을 건강하게 해준다. 필수 아미노산은 몸 속에서 만들어지지 않기 때문에 반드시 음식을 통해서만 체내에 공급된다. 토코페롤 등의 항산화제는 활성산소를 제거해 주는 작용을 통하여 두피의 혈류를 개선시켜 준다. 한편, 칼슘, 철분, 비타민 등 각종 미네랄이 풍부하여 정상적인 모발 대사를 할 수 있도록 도와준다. 한방에서는 검은깨는 간, 신 기능을 강화하고 몸을 튼튼히 하고, 피 순환을 도우며, 피부를 윤기 있고 촉촉하게 하고, 아름다운 검은 머리를 만들고, 내장의 작용을 촉구하여 변통을 돕고, 뇌에도 좋은 영양을 미치는 약으로 취급된다. 세계에서 가장 오랜 의학서인 「신농본초경」에는 간, 신장 및 심장, 비장, 폐의 기능을 보완해 줌으로써 체질개선을 통하여 심신의 건강을 촉진하여 원기와 체력을 증강시키고 머리를 충실히 하며 몸을 가볍게 하는 식품으로 기록되어 있다.Black sesame, which is one of the basic components of the present invention, is recognized to have the highest medicinal effect among herbal types. Sesame seeds, linoleic acid and linolenic acid, which are essential vegetable fats, have a large amount of unsaturated fatty acids that dissolve cholesterol in blood vessels, thereby normalizing blood vessel circulation. Essential amino acids are not produced by the body, so they are only supplied to the body through food. Antioxidants, such as tocopherol, improve the blood flow to the scalp by removing free radicals. On the other hand, it is rich in calcium, iron, vitamins and other minerals to help normal hair metabolism. In Chinese medicine, black sesame seeds strengthen the liver and renal function, strengthen the body, help blood circulation, shine and moisturize the skin, make beautiful dark hair, help the intestines to work, and help nourish the brain. Madness is treated as a medicine. In the world's oldest medical textbook, "Nong-Non-Bone Carbide," it supplements the functions of the liver, kidneys, heart, spleen, and lungs. It is recorded as food.
본 발명의 기본 성분 중의 하나인 대추는 유기산, 아미노산, 비타민 A, B2, 및 C 등의 미량원소와 무기물을 다량 함유하여 모발 등의 대사에 필수적인 영양소를 다량 공급해 주며, 혈청 총단백질과 알부민(Albumin)을 증가시키며 간을 보호하는 작용이 있으며, 한방적으로도 강장작용이 있으며 간을 보호하고 고혈압이나 콩팥 질병 및 이뇨제로 쓰임으로써 간과 신장의 기능을 원활하게 도와줌으로써 탈모방지 및 발모효과를 높인다.Jujube, which is one of the basic components of the present invention, contains a large amount of organic elements, amino acids, vitamins A, B2, and C and the like, and provides a large amount of nutrients essential for metabolism of hair, and includes serum total protein and albumin (Albumin). ) Increases the protective effect of the liver, and also has a tonic effect on the liver and protects the liver and is used as a high blood pressure or kidney disease and diuretics to help the function of the liver and kidney smoothly to increase hair loss prevention and hair growth effect.
본 발명의 기본 성분 중의 하나인 상심자(Mori Semen)는 뽕나무과(Moraceae)식물인 뽕나무(Morus alba L.)의 성숙한 과실의 주성분으로서 지질 63%, 유기산 27%, 알콜 1.6%, 정유 시네올(cineol), 제라니올(geraniol), 캠퍼(camphor), α-피넨 리모넨(pinene limonene), 지방산은 리놀레익 에시드(linoleic acid), 시아니딘(cyanidin), 유기당, 점액질, 아스테린(asterin), 당분, 및 다종의 비타민을 함유하고 있으며, 동의보감에 의하면, 보혈자음(補血滋陰)의 작용을 가지고 있어, 간과 신장의 기력을 도움으로써 오장의 활동을 도와 흰머리를 검게 하고 귀와 눈을 밝게 한다고 기록되어 있다. Mori Semen , one of the basic ingredients of the present invention, is the main component of the mature fruit of Morus alba L. , a Moraceae plant, as a major component of lipid 63%, organic acid 27%, alcohol 1.6%, essential oil cineol ( cineol, geraniol, camphor, α-pinene limonene, fatty acids are linoleic acid, cyanidin, organic sugar, mucus, asterin ), Sugar, and many kinds of vitamins, and according to the agreement, it has the effect of blood-resonant consonants, help the activity of the liver and kidney to help the activity of the five intestines, black hair and brighten ears and eyes It is written.
본 발명의 또 다른 접근 방향인 남성호르몬의 조절 및 두피 혈액순환을 활성화시키는 물질을 찾기 위해 미역, 파래, 톳, 모자반, 및 감태 등 다양한 식용 해조류로부터 생리활성물질을 검색한 결과 감태가 가장 효과가 뛰어난 것으로 밝혀졌다(표 1 및 표 2 참조).Another approach of the present invention is to search for bioactive substances from various edible algae, such as seaweed, seaweed, shellfish, yamban, and Ecklonia cava, to find a substance that regulates male hormones and activates scalp blood circulation. It was found to be excellent (see Table 1 and Table 2).
감태(Ecklonia Cava)는 근해에 서식하는 식용 해조류로서 에틸아세테이트 등의 유기용매로 추출한 추출물이 테스토스테론-5α-환원효소(testosterone-5α-reductase)에 대하여 뛰어난 억제활성을 나타낸다. 남성호르몬인 테스토스테론은 산화환원효소인 테스토스테론-5α-환원효소에 의하여 DHT로 전환되어 궁극적으로세포질내에 존재하는 안드로겐 수용체 단백질과 결합하여 탈모를 유발시키는 특정 단백질들의 발현을 자극하게 된다. 따라서 감태 추출물의 테스토스테론-5α-환원효소에 대한 억제 활성은 DHT 농도를 조절하게 되므로 탈모방지 작용을 나타낼 수 있다. Ecklonia Cava ( Ecklonia Cava ) is an edible seaweed inhabiting the water, and the extract extracted with organic solvents such as ethyl acetate shows an excellent inhibitory activity against testosterone-5α-reductase. Testosterone, a male hormone, is converted to DHT by the oxidoreductase testosterone-5α-reductase and ultimately binds to androgen receptor proteins present in the cytoplasm to stimulate the expression of certain proteins that cause hair loss. Therefore, the inhibitory activity on testosterone-5α-reductase of the Ecklonia cava extract may exhibit a hair loss prevention action because it regulates the concentration of DHT.
한편, 감태의 메탄올 또는 에탄올과 물 혼합용액에 의한 추출물은 강력한 항산화 작용을 가짐으로써 활성산소종(ROS: reactive oxygen species)의 공격에 의한 모세혈관벽의 노화를 방지하여 혈관의 탄력을 개선시켜 혈류를 원활히 할 수 있는 작용을 가진다. 특히 감태 추출물 성분 중에서 단일 물질로 분리된 화학식 1, 2, 및 3으로 표시되는 디카발 A, B, C는 항산화력이 합성물인 부틸히드록시톨루엔 (BHT)등 보다 우수하여 또한 탈모방지 작용을 나타낼 수 있다.Meanwhile, the extract of Ecklonia cavaum or ethanol and water mixture has a powerful antioxidant action, which prevents the aging of capillary walls caused by reactive oxygen species (ROS), improving blood vessel elasticity and improving blood flow. It has an effect that can be done smoothly. In particular, dicarbals A, B, and C represented by the formulas (1), (2), and (3), which are separated from the Ecklonia cava extract components, are superior to butylhydroxytoluene (BHT), which is an antioxidant, and also exhibit anti-hair loss. Can be.
상기 발모 조성물의 제조 방법은 다음과 같다:The preparation method of the said hair growth composition is as follows:
먼저, 감태 0.1∼10 건조중량%, 적하수오 1∼10 건조중량%, 대추 5∼30 건조중량%, 호두 10∼30 건조중량%, 검은 깨 10∼30 건조중량%, 및 상심자 1∼10 건조중량%이 골고루 혼합된 제1혼합물을 제공하고; 식용 바인더 5∼25 중량%에 2∼10 배 생수를 첨가하여 식용 바인더 혼합액을 만든 다음 상기 제1혼합물과 혼합하여 제2혼합물을 제공하고; 상기 제2혼합물을 물중탕으로 80∼98℃에서 2∼10 시간 정도 가열하여 20∼50% 정도 탈수시킴으로써 본 발명의 발모 조성물을 얻는다.First, 0.1-10 dry weight% of Ecklonia cava, 1-10 dry weight% of dripping water, 5-30 dry weight% of jujube, 10-30 dry weight of walnuts, 10-30 dry weight of black sesame seeds, and 1-10 Providing a first mixture in which dry weight percent is evenly mixed; 5 to 25 wt% of the edible binder is added with 2 to 10 times bottled water to form an edible binder mixture and then mixed with the first mixture to provide a second mixture; The second mixture is heated in a water bath at 80 to 98 ° C. for about 2 to 10 hours and dehydrated by about 20 to 50% to obtain a hair growth composition of the present invention.
상기 감태는 먼저 증류수로 세척하여 이물질을 제거한 후에 음지에서 건조한 다음 이를 파쇄하여 분말을 얻어 이를 바로 사용하거나, 또는 실온 조건에서 상기 파쇄된 감태에 유기용매를 가하여 추출물을 얻어 사용한다. 상기 유기용매로는 메탄올, 에탄올, 물과 이들의 혼합물 및 물/에탄올 혼합물로 이루어진 군으로부터 하나 또는 그 이상을 선택하여 사용하는 것이 바람직하다. 선택적으로, 수득율을 높이기 위하여 상기 추출과정을 2회 이상 반복하여 실시할 수 있으며, 이때 반복단계마다 다른 유기용매를 사용할 수 있다. 추출된 물질 내에 함유된 잔사 및 용매를 제거하기 위하여 예를 들면, 원심분리기 및 회전증발 농축기와 같은 분리, 농축수단을 이용할 수 있다. 상기 과정을 거친 추출물을 직접 다양한 응용분야에 사용할 수 있으며, 이러한 경우에는 별도의 추가공정을 요하지 않기 때문에 경제적으로 유리한 장점을 갖는다. 상기 대추는 건조된 조각 또는 분말, 또는 엑기스 형태, 상기 호두는 기름을 추출하거나 또는 추출하지 않은 조각 또는 분말, 상기 검은 깨는 살짝 볶거나 갈아서 기름을 추출하거나 또는 추출하지 않은 상태, 상기 상심자는 분말, 상기 적하수오는 분말 또는 용액으로 사용하는 것이 바람직한데, 이 중 상기 적하수오는 순수한 적하수오 분말, 또는 적하수오와 검은콩을 1:10∼10:1의 비율로 혼합 가열한 후 검정콩을 제거한 나머지 액 또는 상기 액을 건조한 분말을 사용할 수 있다.The Ecklonia cava is first washed with distilled water to remove foreign matters and then dried in the shade and then crushed to obtain a powder, or used immediately, or an organic solvent is added to the crushed Ecklonia cava at room temperature to obtain an extract. The organic solvent is preferably used by selecting one or more from the group consisting of methanol, ethanol, water and mixtures thereof, and water / ethanol mixtures. Optionally, the extraction process may be repeated two or more times in order to increase the yield, wherein a different organic solvent may be used for each repeating step. Separation and concentration means such as, for example, centrifuges and rotary evaporators can be used to remove residues and solvents contained in the extracted material. The above-described extract can be used directly for various applications, and in this case, it does not require a separate additional process, and thus has an economical advantage. The jujube is dried pieces or powder, or extract form, the walnut is extracted or unextracted oil or flakes, the black sesame is slightly roasted or ground, the oil is extracted or not extracted, the heartache is powder, The dripping water is preferably used as a powder or a solution, wherein the dripping water is pure dripping water powder, or mixed with dripping water and black beans at a ratio of 1:10 to 10: 1, and then the black beans are removed. A liquid or powder dried on the liquid can be used.
상기 식용 바인더는 물엿, 설탕, 벌꿀, 한천, 젤라틴, 및 전분으로 이루어진 군으로 부터 적어도 하나 이상 선택되며, 이중 특히 물엿을 사용하는 것이 미각적인 이유로 바람직하고, 선택적으로 주정을 10∼50%의 중량 비율로 포함할 수 있다.The edible binder is at least one selected from the group consisting of starch syrup, sugar, honey, agar, gelatin, and starch. Of these, it is preferable to use starch syrup, particularly for taste reasons, and optionally 10 to 50% by weight of alcohol. It can be included as a ratio.
상기의 방법으로 제조된 발모 조성물은 가공 직후 20∼50g 정도씩 폴리프로필렌 수지 등의 다양한 형태로 진공 포장을 하여 4∼10℃에 보관함으로써 보관성을 높일 수 있다.The hair regrowth composition prepared by the above method can be stored immediately at 20 to 50 g in various forms such as polypropylene resin and stored at 4 to 10 ° C. immediately after processing to increase storage.
상기 발모 조성물은 경구 투여가 바람직하다. 경구투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 이러한 고형제제는 상기 발모 조성물에 적어도 하나 이상의 부형제 예를 들면, 전분, 칼슘카보네이트 (Calcium carbonate), 수크로스(Sucrose) 또는 락토오스 (Lactose), 젤라틴 등을 섞어 조제된다. 또한 단순한 부형제 이외에 마그네슘 스티레이트 탈크 같은 윤활제들도 사용된다. 경구를 위한 액상제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데 흔히 사용되는 단순 희석제인 물, 액상 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다.The hair growth composition is preferably administered orally. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and the solid preparations include at least one excipient such as starch, calcium carbonate, sucrose ( Sucrose) or lactose (Lactose), gelatin, etc. are mixed and prepared. In addition to simple excipients, lubricants such as magnesium styrate talc are also used. Oral liquid preparations include suspensions, solvents, emulsions, and syrups, and may include various excipients such as wetting agents, sweeteners, fragrances, and preservatives, in addition to commonly used simple diluents such as water and liquid paraffin. .
상기의 방법으로 제조된 조성물은 간편하게 섭취할 수 있으며, 탈모증상의 정도에 따라 3∼6개월 동안 1일 20∼120 g씩 1∼3회에 걸쳐 섭취하게 되면 탈모증상이 1∼10년 진행된 사람들의 90% 정도가 회복되며, 원형탈모의 경우 1개월 정도 복용하면 현저하게 머리털이 자라남을 관찰할 수 있다. 한편 방사선 치료 후유증, 중병을 앓고 난 후에 나타나는 탈모의 경우에도 빠른 효과가 나타난다. 따라서, 상기 발모 조성물의 유효용량은 1일 20∼120 g이고, 바람직하기로는 60∼100g 이다.The composition prepared by the above method can be easily ingested, and according to the degree of hair loss, the ingestion of 1 to 3 times 20 to 120 g per day for 3 to 6 months can cause hair loss symptoms of those who have progressed for 1 to 10 years. About 90% is recovered, and in the case of alopecia areata, hair growth can be observed significantly after 1 month. On the other hand, a rapid effect is also seen in the case of hair loss after radiation therapy sequelae and severe illness. Therefore, the effective dose of the said hair regrowth composition is 20-120 g per day, Preferably it is 60-100 g.
이하, 실시예를 통하여 본 발명을 좀 더 구체적으로 살펴보지만, 이에 본 발명의 범주가 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to Examples, but the scope of the present invention is not limited thereto.
실시예 1Example 1
식용 해조류들인 미역, 파래, 톳, 모자반, 및 감태를 채취하여 음건한 뒤에 잘게 분쇄한 다음 각각 100 g씩을 1 ℓ의 둥근 바닥 플라스크에 넣고 실온에서 500 ㎖의 메탄올로 12시간 동안 천천히 교반하여 추출물을 얻었다. 그 다음, 상온에서 원심분리하여 잔사를 제거하였고 회전 증발농축기를 사용하여 메탄올을 제거하였다. 농축된 메탄올 추출물의 양은 각각 미역 20 g, 파래 13 g, 톳 22 g, 모자반 15 g, 및 감태 18 g이었고, 이들의 항산화 활성을 비교 측정하였다.Take seaweeds, seaweeds, oysters, yams, yamban and Ecklonia cava, edible seaweed, and crush them. Got it. The residue was then removed by centrifugation at room temperature and methanol was removed using a rotary evaporator. The amount of concentrated methanol extract was 20 g of brown seaweed, 13 g of green seaweed, 22 g of silk, 15 g of moths and 18 g of Ecklonia cava, and their antioxidant activities were compared and measured.
항산화 활성 측정은 블로이스 방법에 따라 분자에 유리라디칼이 붙은 1,1-디페닐-2-피크릴히드라질(1,1-diphenyl-2-pickrylhydrazil; 이하 'DPPH'라 약칭함)의 라디칼 소거 활성을 측정하였다. 블로이스 방법은 먼저 DPPH 20 ㎎을 에탄올 150 ㎖에 용해시켜 DPPH 용액을 제조하고, 이 용액 600 ㎕에 디메틸설폭사이드(이하 'DMSO'라 약칭함) 250 ㎕를 가하고 적당량의 에탄올로 희석시켜 10초 동안 진탕시킨 후에 517 ㎚에서 대조군의 흡광도가 0.94에서 0.97이 되도록 맞춘다. 동일한 방법으로 흡광도가 0.94에서 0.97인 DPPH 용액 1 ㎖에 각 시료(㎎)를 넣고 완전히 혼합한 후에 10분 동안 반응시켜 흡광도를 측정하여 대조군에 대하여 감소한 흡광도 값을 DPPH 라디칼 소거활성으로 하여 항산화 활성도를 측정하였다. 항산화제 활성의 비교값은 하기 표 1에 나타내었다.Antioxidant activity was determined according to the Bloose method. Radical scavenging of 1,1-diphenyl-2-picrylhydrazyl (hereinafter abbreviated as 'DPPH') with free radicals attached to the molecule Activity was measured. The Blose method first dissolved DPPH 20 mg in 150 ml of ethanol to prepare a DPPH solution, and to 600 µl of this solution was added 250 µl of dimethyl sulfoxide (hereinafter abbreviated as 'DMSO') and diluted with an appropriate amount of ethanol for 10 seconds. After shaking for a while, the absorbance of the control at 517 nm is adjusted from 0.94 to 0.97. In the same way, each sample (mg) was added to 1 ml of DPPH solution with absorbance between 0.94 and 0.97, followed by complete mixing. The absorbance was measured for 10 minutes, and the absorbance value of the control group was reduced to DPPH radical scavenging activity. Measured. Comparative values of antioxidant activity are shown in Table 1 below.
상기 값은 감태 추출물의 각 농도에 대하여 10분 경과 후의 DPPH 라디칼 소거활성 △A를 100%로 하여 상대적인 항산화 활성을 비교한 것이다.The above values compare the relative antioxidant activity of each concentration of Ecklonia cava extract with a DPPH radical scavenging activity ΔA of 100% after 10 minutes.
그 결과 감태의 항산화 활성이 매우 뛰어남을 확인할 수 있었다.As a result, it was confirmed that the antioxidant activity of Ecklonia cava very excellent.
실시예 2Example 2
감태의 테스토스테론-5α-환원효소 저해 활성도Testosterone-5α-Reductase Inhibitory Activity of Ecklonia cava
각 해조류의 추출물은 메탄올 대신에 에틸아세테이트를 사용한 것을 제외하고는 실시예 1과 동일한 방법으로 얻었다. 900 ㎕의 인산완충용액(pH 7.0)에 테스토스테론을 첨가하여 0.2 ㎎/㎖의 농도로 만든 후, 1 ㎎ NADH와 50 ㎕의 테스토스테론 5-α환원효소액을 첨가하여 25℃에서 반응시켰다. 50 ㎕의 완충용액 또는 각각의 해조류 추출물 1 ㎎이 포함된 완충용액 50 ㎕를 첨가하여 340 nm에서의 흡광도 변화 속도를 비교하여 저해 활성을 비교 관찰하였다. 저해활성은 반응초기와 종결 시의 흡광도 차이의 5% 수준의 변화가 일어나는 초기 속도를 비교하여, 추출물이 없는 경우의 반응 속도를 가질 경우를 저해율 0%, 감태 추출물 경우의 반응 속도를 저해율 100%로 하여 비교하였다.Extract of each seaweed was obtained in the same manner as in Example 1 except that ethyl acetate was used instead of methanol. Testosterone was added to 900 μl of phosphate buffer solution (pH 7.0) to make a concentration of 0.2 mg / ml, followed by reaction at 25 ° C. with 1 mg NADH and 50 μl of testosterone 5-α reductase solution. 50 μl of the buffer solution or 50 μl of the buffer solution containing 1 mg of each seaweed extract was added to compare the inhibitory activity by comparing the rate of change of absorbance at 340 nm. The inhibitory activity was compared with the initial rate of change of 5% of the difference in absorbance at the beginning and the end of the reaction.The inhibition rate was 0% for the absence of the extract and the 100% inhibition rate for the Ecklonia cava extract. The comparison was made.
실시예 3Example 3
발모 기능성 식품의 제조Preparation of hair growth functional food
적하수오 15 ㎏, 검정 콩 10 kg, 물 50 kg을 혼합하여 1시간을 끓인 후, 콩을 제거한 나머지를 건조하여 얻은 분말 형태 1.5 kg, 감태 분말 5 kg, 마른 대추조각 15 kg, 호두 가루 13 kg, 검은깨 가루 15 kg, 상심자 가루 9 kg 과 함께 스테인레스 용기에 넣고 골고루 혼합하였다. 상기 혼합물에 물엿 10 kg, 한천가루 8 kg, 생수 130 kg을 더하여 다시 골고루 혼합한 후 물 중탕으로 4시간 가열하여 155 kg의 식품을 얻었다. 2회에 걸친 제조를 하여 303 kg의 위와 같이 제조된 식품을 얻고, 각각 30 g 씩 폴리프로필렌 용기에 진공포장 하였다.15 kg of dripping water, 10 kg of black beans and 50 kg of water were mixed and boiled for 1 hour, and the remaining beans were removed to dry 1.5 kg of powder form, 5 kg of Ecklonia cava, 15 kg of dried jujube pieces, and 13 kg of walnut powder. 15 kg of black sesame powder and 9 kg of mortar powder were placed in a stainless container and mixed evenly. 10 kg of starch syrup, 8 kg of agar powder, and 130 kg of bottled water were added to the mixture, mixed again, and then heated in a water bath for 4 hours to obtain 155 kg of food. Two productions were made to obtain 303 kg of the above food, vacuum packed in polypropylene containers of 30 g each.
실시예 4Example 4
위약(Placebo)의 제조Preparation of Placebo
전분 15 kg, 찹쌀가루 10 kg, 물엿 6 kg, 한천가루 5 kg, 및 검은콩 끓인물 110 kg을 스테인레스 용기에 넣고 골고루 혼합한 후 물 중탕으로 4시간 가열하여 95 kg의 식품을 얻었다. 2회 반복하여 197 kg의 위약을 얻었다. 위와같이 제조된 식품을 각각 30 g 씩 폴리프로필렌 용기에 진공포장하였다.15 kg of starch, 10 kg of glutinous rice flour, 6 kg of starch syrup, 5 kg of agar powder, and 110 kg of black bean boiled water were mixed in a stainless container and mixed evenly and heated for 4 hours in a water bath to obtain 95 kg of food. Repeat 2 times to obtain 197 kg of placebo. Each 30 g of the food prepared as described above was vacuum packed in a polypropylene container.
실시예 5Example 5
실험 대상자의 선정 및 분류 및 효능실험의 진행Selection and classification of test subjects and progress of efficacy test
자연 탈모자로서 1∼10년간 탈모가 진행된 20∼50세의 실험 대상자 총 50명을 선정하여 실험군 (I-a) 30명, 위약군 (I-b) 20명 씩으로 나누었다.As a natural hair loss, a total of 50 subjects aged 20 to 50 years who had lost hair for 1 to 10 years were selected and divided into 30 experimental groups (I-a) and 20 placebo (I-b) groups.
원형 탈모자로서 20∼50세의 실험 대상자 총25명을 선정하여 실험군 (II-a) 15명, 위약군 (II-b) 10명씩으로 나누었다.Twenty-five subjects of 20 to 50 years old were selected as circular hair loss and divided into 15 experimental group (II-a) and 10 placebo group (II-b).
모발 탈색자로서 30∼50세의 실험대상자 15명을 선정하여 실험군 (III-a) 10명, 위약군 (III-b) 5명으로 나누었다.Fifteen subjects aged 30 to 50 years were selected as hair bleachers and divided into ten groups (III-a) and five (III-b) placebo.
각각의 실험군 및 위약군에 대하여 실험식품 및 위약을 3개월간 하루 3회,식후 2시간 후에 30 g 씩 섭취하도록 하고 다음과 같은 관찰을 실험 직전 및 종료 직후에 하여 기록하였다.For each experimental group and placebo group, the experimental food and placebo were ingested 30 g three times a day for three months and two hours after a meal, and the following observations were recorded immediately before and immediately after the end of the experiment.
(1) 발모 갯수의 관찰: 각각의 실험군의 실험 대상자의 실험 시작 직전의 관찰부위 (두피 지름 2.54 cm의 원)를 정확히 정해두고 실험 종료 후와 전의 머리카락의 숫자를 기록하고 그 차의 평균치를 계산하고 그 결과를 하기 표 3에 나타내었다.(1) Observation of the number of hair growth: Accurately determine the observation area (circle with a scalp diameter of 2.54 cm) just before the start of the experiment of each subject, record the number of hairs before and after the experiment and calculate the average of the difference. The results are shown in Table 3 below.
(2) 연구원들에 의한 직접 관찰: 연구원들이 직접 두피의 머리카락을 관찰하고 발모 정도 및 탈색 개선 정도에 대한 관찰결과를 표 2에 개선율%로 나타내었다. 개선율%는 실험전 상태 0%, 완전회복 100%를 기준으로 하여 평가하였고, 그 결과는 하기 표 4에 나타내었다.(2) Direct observation by the researchers: The researchers directly observed the hair of the scalp and the observation results on the degree of hair growth and depigmentation are shown in% of improvement in Table 2. % Improvement was evaluated based on the pre-experimental state 0%, 100% complete recovery, the results are shown in Table 4 below.
(3) 자가평가: 실험대상자 본인에게 다음과 같은 질문을 하였다. "머리 상태가 개선되었습니까?" 그 답은 "예" 와 "아니오" 로 하였으며 "예" 에 대한 비율을 하기 표 5에 나타내었다.(3) Self-assessment: The subjects were asked the following questions. "Is your hair improved?" The answer was "Yes" and "No" and the ratio for "Yes" is shown in Table 5 below.
그 결과 탈모증상이 1∼10년 진행된 사람들의 90% 정도가 회복되었으며, 원형탈모의 경우 1개월 정도 복용하면 현저하게 머리털이 자라남을 확인할 수 있었다.As a result, about 90% of people who had alopecia for 1 to 10 years were recovered, and in the case of alopecia areata, hair growth was remarkable.
상기 실시예에서 본 바와 같이, 본 발명의 발모제는 독성 및 부작용이 없는 식품 및 생약성분을 배합하여 편리하게 섭취하게 함으로써 탈모의 세가지 주요 원인인 남성호르몬의 과다 활동, 두피 혈액순환의 문제, 모발대사에 필수적인 영양소의 결핍 현상을 동시에 차단하여 이러한 탈모요인들을 약화시킬 뿐만 아니라 서로 상승작용을 일으키지 못하게 함으로써 효과적으로 탈모를 방지하고 발모를 촉진하는데 효과적이다.As seen in the above embodiment, the hair regrowth agent of the present invention is a food and herbal ingredient that is not toxic and side effects are conveniently ingested by the three main causes of hair loss, male hormone overactivity, scalp blood circulation problems, hair metabolism It is effective in preventing hair loss and promoting hair growth by simultaneously blocking the deficiency of nutrients essential to the human body, thereby not only weakening these hair loss factors but also preventing synergistic effects from each other.
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KR20040001683A (en) * | 2002-06-28 | 2004-01-07 | 김용규 | Device for manufacturing the natural hair restorer |
WO2011096688A2 (en) * | 2010-02-03 | 2011-08-11 | 라이브켐 주식회사 | Composition for improving scalp and hair health comprising a dibenzo-p-dioxin derivative |
KR101220508B1 (en) * | 2012-03-27 | 2013-01-23 | 주식회사 보타메디 | Composition for improvement of health of scalp and hair comprising dibenzo-p-dioxin derivatives |
KR101299410B1 (en) * | 2004-05-03 | 2013-08-23 | (주)아모레퍼시픽 | Hair cosmetic composition |
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JPH07278003A (en) * | 1994-04-11 | 1995-10-24 | Narisu Keshohin:Kk | Testosterone-5alpha-reductase inhibitor |
KR19990084364A (en) * | 1998-05-06 | 1999-12-06 | 조기원 | Hair regrowth composition and preparation method thereof |
KR20000024499A (en) * | 2000-02-14 | 2000-05-06 | 조종원 | Hair Loss Prevention & Hair Growth Agent |
-
2000
- 2000-09-28 KR KR1020000057086A patent/KR20020025358A/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS591408A (en) * | 1982-06-28 | 1984-01-06 | Fukue Ito | Preparation of hair tonic |
JPS5955815A (en) * | 1982-09-27 | 1984-03-31 | Dai Ichi Seiyaku Co Ltd | Promotor for hair growth |
JPH01230512A (en) * | 1987-08-04 | 1989-09-14 | Osamu Hanakawa | Hair growth promoter |
JPH07278003A (en) * | 1994-04-11 | 1995-10-24 | Narisu Keshohin:Kk | Testosterone-5alpha-reductase inhibitor |
KR19990084364A (en) * | 1998-05-06 | 1999-12-06 | 조기원 | Hair regrowth composition and preparation method thereof |
KR20000024499A (en) * | 2000-02-14 | 2000-05-06 | 조종원 | Hair Loss Prevention & Hair Growth Agent |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040001683A (en) * | 2002-06-28 | 2004-01-07 | 김용규 | Device for manufacturing the natural hair restorer |
KR101299410B1 (en) * | 2004-05-03 | 2013-08-23 | (주)아모레퍼시픽 | Hair cosmetic composition |
WO2011096688A2 (en) * | 2010-02-03 | 2011-08-11 | 라이브켐 주식회사 | Composition for improving scalp and hair health comprising a dibenzo-p-dioxin derivative |
WO2011096688A3 (en) * | 2010-02-03 | 2012-01-05 | 라이브켐 주식회사 | Composition for improving scalp and hair health comprising a dibenzo-p-dioxin derivative |
JP2013518875A (en) * | 2010-02-03 | 2013-05-23 | ボタメディ インク | Composition for improving scalp and hair health comprising dibenzo-p-dioxin derivative |
KR101220508B1 (en) * | 2012-03-27 | 2013-01-23 | 주식회사 보타메디 | Composition for improvement of health of scalp and hair comprising dibenzo-p-dioxin derivatives |
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