JPH01216912A - Hair tonic - Google Patents

Hair tonic

Info

Publication number
JPH01216912A
JPH01216912A JP4183588A JP4183588A JPH01216912A JP H01216912 A JPH01216912 A JP H01216912A JP 4183588 A JP4183588 A JP 4183588A JP 4183588 A JP4183588 A JP 4183588A JP H01216912 A JPH01216912 A JP H01216912A
Authority
JP
Japan
Prior art keywords
hair tonic
forskolin
hair
effect
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4183588A
Other languages
Japanese (ja)
Inventor
Giichi Izumi
儀一 和泉
Tsuguko Wada
和田 嗣子
Tochirou Tatee
舘江 栃郎
Seiji Tsumato
妻藤 清治
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP4183588A priority Critical patent/JPH01216912A/en
Publication of JPH01216912A publication Critical patent/JPH01216912A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin

Abstract

PURPOSE:To obtain a hair tonic exhibiting excellent hair tonic effect, by using forskolin as an active component. CONSTITUTION:Forskolin which is known compound found in the root of a plant of family Labiatae is compounded in a hair tonic in an amount of 0.001-5wt.%, preferably 0.1-2.0wt.%. The hair tonic may contain conventional additives for hair tonic, e.g., peripheral vasodilator, stimulant, vitamins, keratolytic agent, disinfectant, refreshing agent, humectant, etc.

Description

【発明の詳細な説明】 〔産業上の利用分野〕 本発明はフォルスコリンを有効成分とする養毛剤に間す
る。
DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a hair nourishing agent containing forskolin as an active ingredient.

〔従来の技術〕[Conventional technology]

センブリエキス、ビタミンEアセテート等の末梢血管拡
張剤やトウガラシチンキ等の刺激剤は従来から、養毛剤
の成分として用いられてきた。
Peripheral vasodilators such as Oriental japonica extract and vitamin E acetate, and stimulants such as capsicum tincture have been used as ingredients of hair tonics.

〔発明が解決しようとする課題〕[Problem to be solved by the invention]

従来知られている養毛剤は、その効果の不十分なものが
多く、新たな有効成分の出現が期待されている。
Many of the conventionally known hair nourishing agents have insufficient effects, and the emergence of new active ingredients is expected.

〔課題を解決するための手段〕[Means to solve the problem]

そこで本発明者らは種々検討した結果、フォルスコリン
が養毛剤の有効成分として有用であることを見い出した
As a result of various studies, the present inventors have discovered that forskolin is useful as an active ingredient in hair tonics.

本発明は上記知見に基づき完成されたものである。フォ
ルスコリンはシソ科植物Co1eusforskohl
 i iの機中から見い出された既知の化合物である(
テトラヘドロン レター 1669−1672 (19
77))。
The present invention has been completed based on the above findings. Forskolin is a plant of the Lamiaceae family, Coleusforskohl.
It is a known compound found in the aircraft of ii (
Tetrahedron Letter 1669-1672 (19
77)).

本発明の養毛剤におけるフォルスコリンの配合量は、約
0.001〜6重量%程度、好ましくは0.1〜2.0
重量%程度である。
The amount of forskolin in the hair growth agent of the present invention is approximately 0.001 to 6% by weight, preferably 0.1 to 2.0% by weight.
It is about % by weight.

本発明の養毛剤にはフォルスコリンのほか、通常養毛剤
に用いられる添加剤、例えば末梢血管拡張剤(ビタミン
Eアセテート、センブリエキス等)、刺激剤(トウガラ
シチンキ等)、ビタミン類(ビタミンE−B2、B6、
ビオチン、イノジット、パントテン酸、パントテニール
アルコール、ニコチン酸アミドなど) 〔実施例〕 フォルスコリン     0.5g ビタミンEアセテート  0.1 g トウガラシチンキ   適量 グリチルリチン酸    0.05g サリチル酸      0.01g メントール      0.01g グリセリン      1.0 g エタノール       70g 香料         適量 蒸留水        28.32g 総計     100g 上記各成分を混合、均一に溶解して溶液剤を得た。
In addition to forskolin, the hair tonic of the present invention includes additives normally used in hair tonics, such as peripheral vasodilators (vitamin E acetate, Japanese thorns extract, etc.), stimulants (capsicum tincture, etc.), and vitamins (vitamin E-B2, B6,
Biotin, Inosit, pantothenic acid, pantothenyl alcohol, nicotinic acid amide, etc.) [Example] Forskolin 0.5g Vitamin E acetate 0.1g Capsicum tincture Appropriate amount Glycyrrhizic acid 0.05g Salicylic acid 0.01g Menthol 0.01g Glycerin 1 0 g Ethanol 70 g Perfume Appropriate amount Distilled water 28.32 g Total 100 g The above components were mixed and uniformly dissolved to obtain a solution.

〔作用〕[Effect]

75%エタノールにフォルスコリンを0.5W/V%添
加溶解した試料を用い次の実験を行った。
The following experiment was conducted using a sample prepared by adding and dissolving 0.5 W/V% forskolin in 75% ethanol.

1、本養毛剤の皮膚への影響を調べるため、1日2回、
消炎剤(塩酸ジフェンヒドラミン、グリチルレチン酸、
グリチルリチンなど)、角質溶解剤(乳酸、レゾルシン
、サリチル酸など)、殺菌剤(イソプロピルメチルフェ
ノール、塩酸アルキルジアミノエチルグリシン液、パラ
クロルメタキシレノール、第四級アンモニウム塩など)
、清涼剤(メントール、カンファーなど)、湿潤剤(グ
リセリン、プロピレングリコール、1.3−ブチレング
リコール、ソルビトール、ピロリドンカルボン酸ナトリ
ウム、ムコ多糖類など)なとのほかアルコール(エチル
アルコール、ベンジルアルコール、フェネチルアルコー
ルなど)、油性分(オリーブオイル、スクワランなど)
、色素、香料、界面活性剤、高分子(カルボキシビニル
ポリマー、ポリビニルアルコール、メチルセルロースな
ど)、水などをさらに配合することができる。また剤型
的には、ローションタイプ、ゲル、ゲル状クリーム、ク
リーム、乳液などいずれでもよい。
1. To investigate the effect of this hair tonic on the skin, twice a day.
Anti-inflammatory agents (diphenhydramine hydrochloride, glycyrrhetinic acid,
glycyrrhizin, etc.), keratolytic agents (lactic acid, resorcinol, salicylic acid, etc.), disinfectants (isopropylmethylphenol, alkyldiaminoethylglycine hydrochloride solution, parachlormetaxylenol, quaternary ammonium salts, etc.)
, cooling agents (menthol, camphor, etc.), humectants (glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, sodium pyrrolidone carboxylate, mucopolysaccharide, etc.), and alcohols (ethyl alcohol, benzyl alcohol, phenethyl alcohol, etc.). alcohol, etc.), oil-based ingredients (olive oil, squalane, etc.)
, pigments, fragrances, surfactants, polymers (carboxyvinyl polymer, polyvinyl alcohol, methyl cellulose, etc.), water, etc. can be further blended. In terms of dosage form, it may be of any type, such as lotion type, gel, gel-like cream, cream, or milky lotion.

本発明の養毛剤は有効成分のほかに適当量の上記した添
加剤を、それ自体公知の方法またはそれに準する方法に
より製造することができる0通常は上記の所要成分を混
合することによって製造することができる。このように
して製造した組成分は朝晩各1回約1〜6gづつ頭皮ま
たは頭髪にふりかけ手指などで塗擦することにより使用
することができる。
The hair growth agent of the present invention can be manufactured by adding an appropriate amount of the above-mentioned additives in addition to the active ingredients by a method known per se or a method similar thereto.Normally, it can be manufactured by mixing the above-mentioned required ingredients. Can be done. The composition prepared in this manner can be used by sprinkling about 1 to 6 g of the composition on the scalp or hair once in the morning and evening and rubbing it in with fingers or the like.

1回当り50μ9の試料を3週間、マウスの皮膚に塗布
したが、とくに悪い影響は認められなかった。
A sample of 50 μ9 per dose was applied to the skin of mice for 3 weeks, but no particular adverse effects were observed.

2、  II毛作用、脱毛防止作用を確認するため、8
名の壮年性脱毛症の男性(38〜58才)に朝夕1日2
回、適量を6ケ月間頭皮に塗布した。作用の評価の仕方
は写真と本人の自覚症状を併用した。その結果、写真で
発毛効果のあった者 3名 フケ、かゆみがなくなった
者 2名 であり、従って、症状の改善のあったものは
8名中5名であった。
2. II To confirm the hair effect and hair loss prevention effect, 8
Two times a day, morning and evening, for men (38 to 58 years old) with middle-aged alopecia.
Apply an appropriate amount to the scalp once for 6 months. Effects were evaluated using both photographs and the patient's subjective symptoms. As a result, 3 people showed a hair growth effect and 2 people had no dandruff or itching as seen in the photos.Therefore, 5 out of 8 people showed improvement in their symptoms.

〔結果〕〔result〕

以上から明らかなように、フォルスコリンはすぐれた裏
毛効果を発揮するもので、新たな養毛剤として期待され
る。
As is clear from the above, forskolin exhibits an excellent fleece effect and is expected to be used as a new hair growth agent.

Claims (1)

【特許請求の範囲】[Claims] フォルスコリンを有効成分とする養毛剤Hair tonic containing forskolin as an active ingredient
JP4183588A 1988-02-26 1988-02-26 Hair tonic Pending JPH01216912A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4183588A JPH01216912A (en) 1988-02-26 1988-02-26 Hair tonic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4183588A JPH01216912A (en) 1988-02-26 1988-02-26 Hair tonic

Publications (1)

Publication Number Publication Date
JPH01216912A true JPH01216912A (en) 1989-08-30

Family

ID=12619320

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4183588A Pending JPH01216912A (en) 1988-02-26 1988-02-26 Hair tonic

Country Status (1)

Country Link
JP (1) JPH01216912A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970032805A (en) * 1995-12-07 1997-07-22 다카하시 미치나오 Parenting
US6333057B1 (en) * 1995-07-03 2001-12-25 Wilson T. Crandall Composition and method for topical treatment of androgenic alopecia
JP2009298787A (en) * 2008-06-06 2009-12-24 Lvmh Recherche Method for anti-aging cosmetic care by stimulation of survivin expression
JP2011084523A (en) * 2009-10-16 2011-04-28 Nicca Chemical Co Ltd Fibroblast growth factor-7 production promoter, and scalp/hair cosmetic, food and drink containing the same
GB2489206A (en) * 2011-03-14 2012-09-26 James Terence Fletcher A pharmaceutical composition comprising forskolin and sodium cholate
JP2015083571A (en) * 2014-11-21 2015-04-30 日華化学株式会社 Fibroblast growth factor-7 production promoter, and cosmetic for scalp and hair and food and drink containing same

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6333057B1 (en) * 1995-07-03 2001-12-25 Wilson T. Crandall Composition and method for topical treatment of androgenic alopecia
KR970032805A (en) * 1995-12-07 1997-07-22 다카하시 미치나오 Parenting
JP2009298787A (en) * 2008-06-06 2009-12-24 Lvmh Recherche Method for anti-aging cosmetic care by stimulation of survivin expression
JP2011084523A (en) * 2009-10-16 2011-04-28 Nicca Chemical Co Ltd Fibroblast growth factor-7 production promoter, and scalp/hair cosmetic, food and drink containing the same
GB2489206A (en) * 2011-03-14 2012-09-26 James Terence Fletcher A pharmaceutical composition comprising forskolin and sodium cholate
JP2015083571A (en) * 2014-11-21 2015-04-30 日華化学株式会社 Fibroblast growth factor-7 production promoter, and cosmetic for scalp and hair and food and drink containing same

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