JPH0120131B2 - - Google Patents
Info
- Publication number
- JPH0120131B2 JPH0120131B2 JP55040054A JP4005480A JPH0120131B2 JP H0120131 B2 JPH0120131 B2 JP H0120131B2 JP 55040054 A JP55040054 A JP 55040054A JP 4005480 A JP4005480 A JP 4005480A JP H0120131 B2 JPH0120131 B2 JP H0120131B2
- Authority
- JP
- Japan
- Prior art keywords
- parts
- weight
- aerosol
- stock solution
- inflammatory analgesic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 32
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 30
- 239000000443 aerosol Substances 0.000 claims description 28
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 claims description 20
- 239000011550 stock solution Substances 0.000 claims description 20
- 239000004480 active ingredient Substances 0.000 claims description 18
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 18
- 239000003915 liquefied petroleum gas Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 230000000202 analgesic effect Effects 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000003380 propellant Substances 0.000 claims description 15
- 239000000730 antalgic agent Substances 0.000 claims description 13
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 11
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 11
- 241000723346 Cinnamomum camphora Species 0.000 claims description 11
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 11
- 229960000846 camphor Drugs 0.000 claims description 11
- 229930008380 camphor Natural products 0.000 claims description 11
- 229940041616 menthol Drugs 0.000 claims description 11
- 229960002389 glycol salicylate Drugs 0.000 claims description 10
- 229960001047 methyl salicylate Drugs 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 5
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 description 16
- 239000002360 explosive Substances 0.000 description 9
- 239000008213 purified water Substances 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 229940075894 denatured ethanol Drugs 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- -1 C 3 alcohols Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 3
- DLGBEGBHXSAQOC-UHFFFAOYSA-M 2-carboxy-4-methylphenolate Chemical compound CC1=CC=C(O)C(C([O-])=O)=C1 DLGBEGBHXSAQOC-UHFFFAOYSA-M 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 3
- 229960000520 diphenhydramine Drugs 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 235000014692 zinc oxide Nutrition 0.000 description 3
- 239000011787 zinc oxide Substances 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229940111745 camphor / menthol / methyl salicylate Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4005480A JPS56135414A (en) | 1980-03-27 | 1980-03-27 | Aerosol type antiphlogistic and analgesic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4005480A JPS56135414A (en) | 1980-03-27 | 1980-03-27 | Aerosol type antiphlogistic and analgesic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56135414A JPS56135414A (en) | 1981-10-22 |
| JPH0120131B2 true JPH0120131B2 (de) | 1989-04-14 |
Family
ID=12570196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4005480A Granted JPS56135414A (en) | 1980-03-27 | 1980-03-27 | Aerosol type antiphlogistic and analgesic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56135414A (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012033196A1 (ja) | 2010-09-10 | 2012-03-15 | 株式会社ダイゾー | 発泡性エアゾール組成物 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6183117A (ja) * | 1984-09-28 | 1986-04-26 | Sumitomo Chem Co Ltd | エアゾ−ル剤 |
| JPH0778019B2 (ja) * | 1986-11-08 | 1995-08-23 | 久光製薬株式会社 | 泡状エアゾ−ル消炎鎮痛製剤 |
| JP2539890B2 (ja) * | 1988-06-13 | 1996-10-02 | 東洋エアゾール工業株式会社 | 非冷却性エアゾ―ル製品 |
| ES2103737T3 (es) * | 1989-03-17 | 1997-10-01 | Taisho Pharmaceutical Co Ltd | Preparacion de aerosol para uso externo. |
| US5976504A (en) * | 1993-08-10 | 1999-11-02 | The Boots Company, Plc | Topical aerosol formulation for cooling of mammalian tissues |
| WO1997005858A1 (fr) * | 1995-08-10 | 1997-02-20 | Taisho Pharmaceutical Co., Ltd. | Preparation pour aerosol |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4899316A (de) * | 1972-04-06 | 1973-12-15 | ||
| JPS5221051A (en) * | 1975-08-09 | 1977-02-17 | Lion Corp | Halogen-containing resin composition |
| JPS5432185A (en) * | 1977-08-16 | 1979-03-09 | Osaka Eyazooru Kougiyou Kk | Method of manufacturing nonnfoaming and sprayable waterrcontaining aerosol products |
| JPS5529524A (en) * | 1978-08-21 | 1980-03-01 | Toyo Aerosol Kogyo Kk | Powdery aerosol composition |
-
1980
- 1980-03-27 JP JP4005480A patent/JPS56135414A/ja active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4899316A (de) * | 1972-04-06 | 1973-12-15 | ||
| JPS5221051A (en) * | 1975-08-09 | 1977-02-17 | Lion Corp | Halogen-containing resin composition |
| JPS5432185A (en) * | 1977-08-16 | 1979-03-09 | Osaka Eyazooru Kougiyou Kk | Method of manufacturing nonnfoaming and sprayable waterrcontaining aerosol products |
| JPS5529524A (en) * | 1978-08-21 | 1980-03-01 | Toyo Aerosol Kogyo Kk | Powdery aerosol composition |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012033196A1 (ja) | 2010-09-10 | 2012-03-15 | 株式会社ダイゾー | 発泡性エアゾール組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56135414A (en) | 1981-10-22 |
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