JPH01131023A - 経口用リン酸イオン吸着剤 - Google Patents
経口用リン酸イオン吸着剤Info
- Publication number
- JPH01131023A JPH01131023A JP62290215A JP29021587A JPH01131023A JP H01131023 A JPH01131023 A JP H01131023A JP 62290215 A JP62290215 A JP 62290215A JP 29021587 A JP29021587 A JP 29021587A JP H01131023 A JPH01131023 A JP H01131023A
- Authority
- JP
- Japan
- Prior art keywords
- aluminum hydroxide
- boehmite
- phosphoric acid
- oral use
- adsorbent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 title claims abstract description 48
- 239000003463 adsorbent Substances 0.000 title claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 239000004480 active ingredient Substances 0.000 title claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 title abstract description 11
- 229910000147 aluminium phosphate Inorganic materials 0.000 title abstract description 7
- -1 phosphoric acid ion Chemical class 0.000 title abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 19
- FAHBNUUHRFUEAI-UHFFFAOYSA-M hydroxidooxidoaluminium Chemical compound O[Al]=O FAHBNUUHRFUEAI-UHFFFAOYSA-M 0.000 claims description 33
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 25
- 229940085991 phosphate ion Drugs 0.000 claims description 22
- 229910017089 AlO(OH) Inorganic materials 0.000 claims 3
- 238000003756 stirring Methods 0.000 abstract description 13
- 208000001647 Renal Insufficiency Diseases 0.000 abstract description 3
- 238000010335 hydrothermal treatment Methods 0.000 abstract description 3
- 201000006370 kidney failure Diseases 0.000 abstract description 3
- 239000007921 spray Substances 0.000 abstract description 3
- 239000006185 dispersion Substances 0.000 abstract description 2
- 229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 3
- 229910001679 gibbsite Inorganic materials 0.000 abstract 3
- 229940024545 aluminum hydroxide Drugs 0.000 description 34
- 229910001593 boehmite Inorganic materials 0.000 description 30
- 238000001179 sorption measurement Methods 0.000 description 18
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 15
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 15
- 239000000843 powder Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 150000002500 ions Chemical class 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 230000000704 physical effect Effects 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000002329 infrared spectrum Methods 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 206010005949 Bone cancer Diseases 0.000 description 2
- 208000018084 Bone neoplasm Diseases 0.000 description 2
- 208000014644 Brain disease Diseases 0.000 description 2
- 208000032274 Encephalopathy Diseases 0.000 description 2
- 238000004566 IR spectroscopy Methods 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000001447 alkali salts Chemical class 0.000 description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- BNGXYYYYKUGPPF-UHFFFAOYSA-M (3-methylphenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].CC1=CC=CC(C[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 BNGXYYYYKUGPPF-UHFFFAOYSA-M 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 208000037147 Hypercalcaemia Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ANBBXQWFNXMHLD-UHFFFAOYSA-N aluminum;sodium;oxygen(2-) Chemical compound [O-2].[O-2].[Na+].[Al+3] ANBBXQWFNXMHLD-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 239000011609 ammonium molybdate Substances 0.000 description 1
- APUPEJJSWDHEBO-UHFFFAOYSA-P ammonium molybdate Chemical compound [NH4+].[NH4+].[O-][Mo]([O-])(=O)=O APUPEJJSWDHEBO-UHFFFAOYSA-P 0.000 description 1
- 235000018660 ammonium molybdate Nutrition 0.000 description 1
- 229940010552 ammonium molybdate Drugs 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000000148 hypercalcaemia Effects 0.000 description 1
- 208000030915 hypercalcemia disease Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229910001388 sodium aluminate Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62290215A JPH01131023A (ja) | 1987-11-16 | 1987-11-16 | 経口用リン酸イオン吸着剤 |
| EP88310703A EP0318191B1 (en) | 1987-11-16 | 1988-11-14 | Oral phosphate ion adsorbent |
| DE8888310703T DE3873279T2 (de) | 1987-11-16 | 1988-11-14 | Orales adsorbens fuer phosphat-ionen. |
| US07/271,329 US4931289A (en) | 1987-11-16 | 1988-11-15 | Oral phosphate ion adsorbent |
| CA000583276A CA1329765C (en) | 1987-11-16 | 1988-11-16 | Oral phosphate ion adsorbent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62290215A JPH01131023A (ja) | 1987-11-16 | 1987-11-16 | 経口用リン酸イオン吸着剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01131023A true JPH01131023A (ja) | 1989-05-23 |
| JPH0513092B2 JPH0513092B2 (en, 2012) | 1993-02-19 |
Family
ID=17753242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62290215A Granted JPH01131023A (ja) | 1987-11-16 | 1987-11-16 | 経口用リン酸イオン吸着剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4931289A (en, 2012) |
| EP (1) | EP0318191B1 (en, 2012) |
| JP (1) | JPH01131023A (en, 2012) |
| CA (1) | CA1329765C (en, 2012) |
| DE (1) | DE3873279T2 (en, 2012) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04230315A (ja) * | 1990-12-27 | 1992-08-19 | Haamuresu Prod:Kk | 歯磨類 |
| JP2010095398A (ja) * | 2008-10-15 | 2010-04-30 | Kyowa Chem Ind Co Ltd | 水酸化アルミニウムゲル粒子およびその製造方法 |
| JP2020172415A (ja) * | 2019-04-12 | 2020-10-22 | 多木化学株式会社 | 大粒径アルミナ分散液 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012209411A1 (de) * | 2012-06-04 | 2013-12-05 | Fim Biotech Gmbh | Mineralische Verbindung zur Reduzierung von anorganischen Phosphaten, insbesondere im Rahmen einer Nierenersatztherapie |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4931597A (en, 2012) * | 1972-07-21 | 1974-03-22 | ||
| JPS5472797A (en) * | 1977-11-21 | 1979-06-11 | Purdue Research Foundation | Manufacture of dry amorphous aluminum hydroxide gel |
| JPS5913446A (ja) * | 1982-07-14 | 1984-01-24 | Hitachi Ltd | 分散処理システム |
| JPS6114829A (ja) * | 1984-06-28 | 1986-01-23 | Mitsubishi Heavy Ind Ltd | 工作機械 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2618083A1 (de) * | 1976-04-24 | 1977-11-03 | Manfred Dr Kaemper | Mittel zur phosphatprophylaxe |
| DE3147869A1 (de) * | 1981-12-03 | 1983-06-16 | Nefro-Pharma, Arzneimittelvertrieb GmbH, 8203 Oberaudorf | Aluminiumchloridhydroxidhydrat-komplex als arzneimittel zur phosphatbindung und verfahren zu deren herstellung |
| FR2527197B1 (fr) * | 1982-05-19 | 1985-06-21 | Rhone Poulenc Spec Chim | Procede de fabrication de billes d'alumine mises en forme par coagulation en gouttes |
-
1987
- 1987-11-16 JP JP62290215A patent/JPH01131023A/ja active Granted
-
1988
- 1988-11-14 DE DE8888310703T patent/DE3873279T2/de not_active Expired - Lifetime
- 1988-11-14 EP EP88310703A patent/EP0318191B1/en not_active Expired - Lifetime
- 1988-11-15 US US07/271,329 patent/US4931289A/en not_active Expired - Lifetime
- 1988-11-16 CA CA000583276A patent/CA1329765C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4931597A (en, 2012) * | 1972-07-21 | 1974-03-22 | ||
| JPS5472797A (en) * | 1977-11-21 | 1979-06-11 | Purdue Research Foundation | Manufacture of dry amorphous aluminum hydroxide gel |
| JPS5913446A (ja) * | 1982-07-14 | 1984-01-24 | Hitachi Ltd | 分散処理システム |
| JPS6114829A (ja) * | 1984-06-28 | 1986-01-23 | Mitsubishi Heavy Ind Ltd | 工作機械 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04230315A (ja) * | 1990-12-27 | 1992-08-19 | Haamuresu Prod:Kk | 歯磨類 |
| JP2010095398A (ja) * | 2008-10-15 | 2010-04-30 | Kyowa Chem Ind Co Ltd | 水酸化アルミニウムゲル粒子およびその製造方法 |
| JP2020172415A (ja) * | 2019-04-12 | 2020-10-22 | 多木化学株式会社 | 大粒径アルミナ分散液 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0318191B1 (en) | 1992-07-29 |
| DE3873279T2 (de) | 1992-12-03 |
| JPH0513092B2 (en, 2012) | 1993-02-19 |
| EP0318191A1 (en) | 1989-05-31 |
| DE3873279D1 (en) | 1992-09-03 |
| CA1329765C (en) | 1994-05-24 |
| US4931289A (en) | 1990-06-05 |
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