JP7847578B2 - Ｆｌｔ３リガンド融合タンパク質及び使用方法 - Google Patents

Ｆｌｔ３リガンド融合タンパク質及び使用方法

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Publication number
JP7847578B2
JP7847578B2 JP2023507882A JP2023507882A JP7847578B2 JP 7847578 B2 JP7847578 B2 JP 7847578B2 JP 2023507882 A JP2023507882 A JP 2023507882A JP 2023507882 A JP2023507882 A JP 2023507882A JP 7847578 B2 JP7847578 B2 JP 7847578B2
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JP
Japan
Prior art keywords
flt3l
seq
fusion protein
protein
amino acid
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Active
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JP2023507882A
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English (en)
Japanese (ja)
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JP2023536655A (ja
JP2023536655A5 (https=
Inventor
イーチン リウ，
クリスティーン カリーヌ ムシオン，
トラヴィス ウィリアム ベインブリッジ，
イーラジ ホッセイニ，
グレゴリー アラン ラザー，
シヴァン コーエン，
クリストファー チャールズ ケンバル，
ジル エム． シャルトナー，
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Genentech Inc
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Genentech Inc
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Publication of JP2023536655A publication Critical patent/JP2023536655A/ja
Publication of JP2023536655A5 publication Critical patent/JP2023536655A5/ja
Application granted granted Critical
Publication of JP7847578B2 publication Critical patent/JP7847578B2/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2023507882A 2020-08-07 2021-08-05 Ｆｌｔ３リガンド融合タンパク質及び使用方法 Active JP7847578B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063062713P 2020-08-07 2020-08-07
US63/062,713 2020-08-07
PCT/US2021/044586 WO2022031876A1 (en) 2020-08-07 2021-08-05 Flt3 ligand fusion proteins and methods of use

Publications (3)

Publication Number Publication Date
JP2023536655A JP2023536655A (ja) 2023-08-28
JP2023536655A5 JP2023536655A5 (https=) 2024-08-13
JP7847578B2 true JP7847578B2 (ja) 2026-04-17

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JP2023507882A Active JP7847578B2 (ja) 2020-08-07 2021-08-05 Ｆｌｔ３リガンド融合タンパク質及び使用方法

Country Status (18)

Country Link
US (2) US11542308B2 (https=)
EP (1) EP4192854A1 (https=)
JP (1) JP7847578B2 (https=)
KR (1) KR20230042596A (https=)
CN (1) CN116234830A (https=)
AR (1) AR123158A1 (https=)
AU (1) AU2021322239A1 (https=)
BR (1) BR112023002123A2 (https=)
CA (1) CA3188426A1 (https=)
CL (1) CL2023000381A1 (https=)
CO (1) CO2023001488A2 (https=)
CR (1) CR20230119A (https=)
IL (1) IL300260A (https=)
MX (2) MX2023001441A (https=)
PE (1) PE20230983A1 (https=)
TW (1) TW202221016A (https=)
WO (1) WO2022031876A1 (https=)
ZA (1) ZA202300862B (https=)

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WO2022245671A1 (en) 2021-05-18 2022-11-24 Gilead Sciences, Inc. Methods of using flt3l-fc fusion proteins
TWI910028B (zh) 2021-06-11 2025-12-21 美商基利科學股份有限公司 Mcl-1抑制劑與抗癌劑之組合
US11931424B2 (en) 2021-06-11 2024-03-19 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-body drug conjugates
EP4532728A2 (en) * 2022-06-03 2025-04-09 The University of Chicago Antigen tolerance induction through use of flt3l variants

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WO2022031876A1 (en) 2022-02-10
CR20230119A (es) 2023-05-16
CL2023000381A1 (es) 2023-07-28
AR123158A1 (es) 2022-11-02
JP2023536655A (ja) 2023-08-28
ZA202300862B (en) 2025-05-28
BR112023002123A2 (pt) 2023-03-07
IL300260A (en) 2023-03-01
PE20230983A1 (es) 2023-06-21
US20220289803A1 (en) 2022-09-15
US20230279067A1 (en) 2023-09-07
MX2023001440A (es) 2023-03-06
MX2023001441A (es) 2023-03-06
KR20230042596A (ko) 2023-03-28
EP4192854A1 (en) 2023-06-14
CN116234830A (zh) 2023-06-06
AU2021322239A1 (en) 2023-02-23
CA3188426A1 (en) 2022-02-10
US11542308B2 (en) 2023-01-03
TW202221016A (zh) 2022-06-01
CO2023001488A2 (es) 2023-02-16

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