JP7843116B2 - ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態 - Google Patents

２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態

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Publication number
JP7843116B2
JP7843116B2 JP2020536496A JP2020536496A JP7843116B2 JP 7843116 B2 JP7843116 B2 JP 7843116B2 JP 2020536496 A JP2020536496 A JP 2020536496A JP 2020536496 A JP2020536496 A JP 2020536496A JP 7843116 B2 JP7843116 B2 JP 7843116B2
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approximately
compound
morphology
polymorph
solvent
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Japanese (ja)
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JP2020533412A (ja
JP2020533412A5 (enExample
Inventor
マイケル ピー． スモリンスキ
Original Assignee
エイティーエヌエックス エスピーブイ リミテッド ライアビリティ カンパニー
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Application filed by エイティーエヌエックス エスピーブイ リミテッド ライアビリティ カンパニー filed Critical エイティーエヌエックス エスピーブイ リミテッド ライアビリティ カンパニー
Publication of JP2020533412A publication Critical patent/JP2020533412A/ja
Publication of JP2020533412A5 publication Critical patent/JP2020533412A5/ja
Priority to JP2023107781A priority Critical patent/JP2023157909A/ja
Priority to JP2025091579A priority patent/JP2025131661A/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020536496A 2017-09-07 2018-09-07 ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態 Active JP7843116B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023107781A JP2023157909A (ja) 2017-09-07 2023-06-30 ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態
JP2025091579A JP2025131661A (ja) 2017-09-07 2025-06-02 ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762555390P 2017-09-07 2017-09-07
US62/555,390 2017-09-07
PCT/US2018/049829 WO2019051147A1 (en) 2017-09-07 2018-09-07 SOLID FORMS OF 2- (5- (4- (2-MORPHOLINOETHOXY) PHENYL) PYRIDIN-2-YL) -N-BENZYLACETAMIDE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023107781A Division JP2023157909A (ja) 2017-09-07 2023-06-30 ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態

Publications (3)

Publication Number Publication Date
JP2020533412A JP2020533412A (ja) 2020-11-19
JP2020533412A5 JP2020533412A5 (enExample) 2021-09-30
JP7843116B2 true JP7843116B2 (ja) 2026-04-09

Family

ID=65517772

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020536496A Active JP7843116B2 (ja) 2017-09-07 2018-09-07 ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態
JP2023107781A Pending JP2023157909A (ja) 2017-09-07 2023-06-30 ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態
JP2025091579A Withdrawn JP2025131661A (ja) 2017-09-07 2025-06-02 ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023107781A Pending JP2023157909A (ja) 2017-09-07 2023-06-30 ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態
JP2025091579A Withdrawn JP2025131661A (ja) 2017-09-07 2025-06-02 ２－（５－（４－（２－モルホリノエトキシ）フェニル）ピリジン－２－イル）－ｎ－ベンジルアセトアミドの固体形態

Country Status (24)

Country Link
US (4) US10669236B2 (enExample)
EP (2) EP4674486A3 (enExample)
JP (3) JP7843116B2 (enExample)
KR (2) KR102691700B1 (enExample)
CN (2) CN111278808B (enExample)
AU (2) AU2018330163B2 (enExample)
BR (1) BR112020004419A2 (enExample)
CA (1) CA3074831A1 (enExample)
DK (1) DK3679016T3 (enExample)
ES (1) ES3056703T3 (enExample)
FI (1) FI3679016T3 (enExample)
HR (1) HRP20260002T1 (enExample)
IL (2) IL326637A (enExample)
LT (1) LT3679016T (enExample)
MX (2) MX2020002622A (enExample)
PL (1) PL3679016T3 (enExample)
PT (1) PT3679016T (enExample)
RS (1) RS67706B1 (enExample)
SG (1) SG11202001868RA (enExample)
SI (1) SI3679016T1 (enExample)
SM (1) SMT202500467T1 (enExample)
TW (1) TWI815820B (enExample)
WO (1) WO2019051147A1 (enExample)
ZA (1) ZA202106139B (enExample)

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US7968574B2 (en) * 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
EP4186890A1 (en) 2021-11-29 2023-05-31 Moehs Ibérica, S.L. Preparation of n-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide for the synthesis of tirbanibulin
CN115010655A (zh) * 2022-07-21 2022-09-06 重庆迈德凯医药有限公司 一种替尼布林的纯化方法
WO2026022219A1 (en) 2024-07-24 2026-01-29 Almirall, S.A. Injectable formulations comprising tirbanibulin

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN106810490A (zh) 2017-02-06 2017-06-09 重庆泰润制药有限公司 一种二芳基化合物的晶型及其制备方法和应用

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US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US7141593B1 (en) * 1999-06-04 2006-11-28 Abbott Laboratories Pharmaceutical formulations
DE60209704T2 (de) * 2001-05-22 2006-11-16 Pfizer Products Inc., Groton Neue kristallforme von azithromycin
US6821502B2 (en) * 2002-06-12 2004-11-23 Chevron U.S.A. Inc. Method of making aluminum-containing zeolite with IFR structure
US7351833B2 (en) * 2004-07-23 2008-04-01 Abbott Laboratories (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
PL1836169T3 (pl) 2004-12-28 2012-07-31 Kinex Pharmaceuticals Llc Kompozycje i sposoby leczenia zaburzeń związanych z proliferacją komórek
MY152185A (en) * 2005-06-10 2014-08-29 Novartis Ag Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
DE602006019822D1 (de) * 2005-09-13 2011-03-10 Sicor Inc Reines rocuroniumbromid
ES2500165T3 (es) * 2006-06-29 2014-09-30 Kinex Pharmaceuticals, Llc Composiciones de biarilo y métodos para modular una cascada de quinasas
KR20090064400A (ko) * 2006-09-28 2009-06-18 머크 앤드 캄파니 인코포레이티드 Ｈｄａｃ 억제제 및 킬레이트화 가능한 금속 화합물 및 금속-ｈｄａｃ 억제제 킬레이트 착물의 약제학적 조성물
US7837978B2 (en) * 2006-10-13 2010-11-23 Chevron U.S.A. Inc. Process for preparing aluminum-containing molecular sieve SSZ-26
PE20081506A1 (es) * 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
US7935697B2 (en) * 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
TWI457336B (zh) * 2006-12-28 2014-10-21 Kinex Pharmaceuticals Llc 調節激酶級聯之組成物及方法
US7939529B2 (en) 2007-05-17 2011-05-10 Kinex Pharmaceuticals, Llc Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
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WO2015069217A1 (en) * 2013-11-05 2015-05-14 Baylor College Of Medicine Src kinase inhibition as treatment for lympangioleiomyomatosis and tuberous sclerosis
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CN106810490A (zh) 2017-02-06 2017-06-09 重庆泰润制药有限公司 一种二芳基化合物的晶型及其制备方法和应用

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平山令明編著、有機化合物結晶作製ハンドブック －原理とノウハウ－、丸善株式会社、平成２０年７月２５日、１７～２３、３７～４０、４５～５１、５７～６５頁

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US20220098152A1 (en) 2022-03-31
BR112020004419A2 (pt) 2020-09-08
SMT202500467T1 (it) 2026-03-09
RU2020112539A3 (enExample) 2022-04-19
DK3679016T3 (da) 2025-12-15
KR20200081359A (ko) 2020-07-07
US12215083B2 (en) 2025-02-04
AU2023201010A1 (en) 2023-03-23
AU2018330163A1 (en) 2020-03-26
HRP20260002T1 (hr) 2026-02-27
CN111278808A (zh) 2020-06-12
TW201920160A (zh) 2019-06-01
MX2023001805A (es) 2023-03-13
AU2018330163B2 (en) 2023-02-02
KR102691700B1 (ko) 2024-08-02
IL272992A (en) 2020-04-30
CA3074831A1 (en) 2019-03-14
AU2023201010B2 (en) 2024-10-03
CN111278808B (zh) 2024-04-26
CN118439992A (zh) 2024-08-06
KR20240119192A (ko) 2024-08-06
JP2025131661A (ja) 2025-09-09
MX2020002622A (es) 2020-10-01
EP4674486A3 (en) 2026-03-25
LT3679016T (lt) 2026-02-10
SG11202001868RA (en) 2020-03-30
EP4674486A2 (en) 2026-01-07
RS67706B1 (sr) 2026-02-27
FI3679016T3 (fi) 2025-12-12
SI3679016T1 (sl) 2026-04-30
EP3679016A1 (en) 2020-07-15
US20200255380A1 (en) 2020-08-13
US20250115555A1 (en) 2025-04-10
ZA202106139B (en) 2026-04-29
RU2020112539A (ru) 2021-10-08
PL3679016T3 (pl) 2026-03-02
PT3679016T (pt) 2025-12-05
JP2020533412A (ja) 2020-11-19
US20190071402A1 (en) 2019-03-07
TWI815820B (zh) 2023-09-21
US10669236B2 (en) 2020-06-02
IL326637A (en) 2026-04-01
ES3056703T3 (en) 2026-02-24
US11230527B2 (en) 2022-01-25
WO2019051147A1 (en) 2019-03-14
JP2023157909A (ja) 2023-10-26
EP3679016A4 (en) 2021-09-29
EP3679016B1 (en) 2025-11-05

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