JP7841882B2 - アルデヒド変性ヒアルロン酸、それを調製するための方法およびその用途 - Google Patents

アルデヒド変性ヒアルロン酸、それを調製するための方法およびその用途

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Publication number
JP7841882B2
JP7841882B2 JP2021533292A JP2021533292A JP7841882B2 JP 7841882 B2 JP7841882 B2 JP 7841882B2 JP 2021533292 A JP2021533292 A JP 2021533292A JP 2021533292 A JP2021533292 A JP 2021533292A JP 7841882 B2 JP7841882 B2 JP 7841882B2
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Prior art keywords
hyaluronic acid
modified hyaluronic
acid derivative
modified
derivative
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JP2021533292A
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English (en)
Japanese (ja)
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JP2022512363A (ja
Inventor
プリット，パトリック
ドレーベ，コリン
ミューラー，シビュレ
ブキセビィック，ラドヴァン
ノイバウアー，ジェンス
ライザー，シャルロット
Original Assignee
メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/17—Amines; Quaternary ammonium compounds
    • C08K5/175—Amines; Quaternary ammonium compounds containing COOH-groups; Esters or salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/594—Mixtures of polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/882—Mixing prior to application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/95—Involves in-situ formation or cross-linking of polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021533292A 2018-12-19 2019-12-18 アルデヒド変性ヒアルロン酸、それを調製するための方法およびその用途 Active JP7841882B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP18214028.5 2018-12-19
EP18214028 2018-12-19
EP19191042.1 2019-08-09
EP19191042 2019-08-09
PCT/EP2019/085829 WO2020127407A1 (en) 2018-12-19 2019-12-18 Aldehyde-modified hyaluronic acid, method for preparing same and applications thereof

Publications (2)

Publication Number Publication Date
JP2022512363A JP2022512363A (ja) 2022-02-03
JP7841882B2 true JP7841882B2 (ja) 2026-04-07

Family

ID=69056037

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021533292A Active JP7841882B2 (ja) 2018-12-19 2019-12-18 アルデヒド変性ヒアルロン酸、それを調製するための方法およびその用途

Country Status (10)

Country Link
US (1) US20220062151A1 (he)
EP (1) EP3898703A1 (he)
JP (1) JP7841882B2 (he)
KR (1) KR102855946B1 (he)
CN (1) CN113508143A (he)
AU (1) AU2019407867B2 (he)
IL (1) IL283513B2 (he)
MX (1) MX2021007083A (he)
SG (1) SG11202105486TA (he)
WO (1) WO2020127407A1 (he)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4139366A4 (en) * 2020-04-23 2024-05-22 Pleryon Therapeutics (Shenzhen) Limited BIOCOMPATIBLE MATERIAL AND METHODS OF MANUFACTURE AND USE THEREOF
TWI880094B (zh) 2021-06-23 2025-04-11 德商莫茲製藥有限兩合公司 以絲蛋白交聯多醣及所得材料之用途
CN113827779B (zh) * 2021-08-14 2022-07-26 中国海洋大学 一种生物多糖水凝胶及其制备方法和应用
US20250002659A1 (en) * 2021-09-02 2025-01-02 Supansa YODMUANG Method of preparing hyaluronic acid-alginate (ha-alg) hydrogel and ha-alg hydrogel
CN114805631A (zh) * 2022-03-01 2022-07-29 吉林省奇健生物技术有限公司 高活性透明质酸-多肽缀合物及其制备方法和应用
AU2023392523A1 (en) 2022-12-15 2025-04-10 Merz Pharma Gmbh & Co. Kgaa Injectable gel comprising botulinum toxin and uses thereof
CN119280474A (zh) * 2024-09-29 2025-01-10 湖南朗晶医疗科技有限公司 玻璃体凝胶及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529086A (ja) 2006-03-07 2009-08-13 プロコン バイオテック リミテッド ヒアルロン酸のヒドラジド誘導体
US20120004194A1 (en) 2009-07-02 2012-01-05 E. I. Du Pont Nemours And Company Aldehyde-functionalized polysaccharides
JP2019509385A (ja) 2016-03-24 2019-04-04 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー 修飾ヒアルロン酸、その製造方法、およびそれらの使用

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US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
EP3456749B1 (en) 2008-02-29 2021-07-14 PVAC Medical Technologies Ltd. A substituted polyvinyl alcohol reagent
US8186843B2 (en) 2008-12-17 2012-05-29 M-Edge Accessories, Llc Booklight for a protective cover of an eReader
US8778326B2 (en) * 2009-07-02 2014-07-15 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
CZ302503B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
US8197849B2 (en) 2010-02-12 2012-06-12 National Health Research Institutes Cross-linked oxidated hyaluronic acid for use as a vitreous substitute
EP2537867B1 (en) * 2010-02-19 2016-11-02 Kewpie Corporation Modified hyaluronic acid and/or salt thereof, method for producing same and cosmetic comprising same
RU2017124620A (ru) 2014-12-18 2019-01-21 Гальдерма С.А. Прививка циклодекстрина амидными связями к гиалуроновой кислоте, поперечно сшитой эфиром, и их применение
EP3156044A1 (en) * 2015-10-16 2017-04-19 Merz Pharma GmbH & Co. KGaA In situ cross-linkable polysaccharide compositions and uses thereof

Patent Citations (3)

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JP2009529086A (ja) 2006-03-07 2009-08-13 プロコン バイオテック リミテッド ヒアルロン酸のヒドラジド誘導体
US20120004194A1 (en) 2009-07-02 2012-01-05 E. I. Du Pont Nemours And Company Aldehyde-functionalized polysaccharides
JP2019509385A (ja) 2016-03-24 2019-04-04 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー 修飾ヒアルロン酸、その製造方法、およびそれらの使用

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Also Published As

Publication number Publication date
JP2022512363A (ja) 2022-02-03
AU2019407867B2 (en) 2024-09-26
TW202041221A (zh) 2020-11-16
BR112021011574A2 (pt) 2021-08-31
KR102855946B1 (ko) 2025-09-04
EP3898703A1 (en) 2021-10-27
AU2019407867A1 (en) 2021-07-08
SG11202105486TA (en) 2021-06-29
WO2020127407A1 (en) 2020-06-25
IL283513A (he) 2021-07-29
KR20210124963A (ko) 2021-10-15
CA3123341A1 (en) 2020-06-25
US20220062151A1 (en) 2022-03-03
IL283513B1 (he) 2024-09-01
IL283513B2 (he) 2025-01-01
CN113508143A (zh) 2021-10-15
MX2021007083A (es) 2021-10-13

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