JP7832120B2 - 免疫グロブリン変異体 - Google Patents

免疫グロブリン変異体

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Publication number
JP7832120B2
JP7832120B2 JP2022565970A JP2022565970A JP7832120B2 JP 7832120 B2 JP7832120 B2 JP 7832120B2 JP 2022565970 A JP2022565970 A JP 2022565970A JP 2022565970 A JP2022565970 A JP 2022565970A JP 7832120 B2 JP7832120 B2 JP 7832120B2
Authority
JP
Japan
Prior art keywords
variant
antibody
polypeptide
amino acid
parent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022565970A
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English (en)
Japanese (ja)
Other versions
JP2023523760A (ja
JP2023523760A5 (https=
Inventor
ブランケンシップ，ジョン
グヨット，ジャスティン
ホルムベルグ，ブライアン
イリガレイ，セバスチャン
スケグロ，ダルコ
Original Assignee
ノバルティス アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2023523760A publication Critical patent/JP2023523760A/ja
Publication of JP2023523760A5 publication Critical patent/JP2023523760A5/ja
Priority to JP2025200590A priority Critical patent/JP2026048674A/ja
Application granted granted Critical
Publication of JP7832120B2 publication Critical patent/JP7832120B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022565970A 2020-05-01 2021-04-29 免疫グロブリン変異体 Active JP7832120B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025200590A JP2026048674A (ja) 2020-05-01 2025-11-20 免疫グロブリン変異体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063018698P 2020-05-01 2020-05-01
US63/018,698 2020-05-01
PCT/IB2021/053585 WO2021220218A1 (en) 2020-05-01 2021-04-29 Immunoglobulin variants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025200590A Division JP2026048674A (ja) 2020-05-01 2025-11-20 免疫グロブリン変異体

Publications (3)

Publication Number Publication Date
JP2023523760A JP2023523760A (ja) 2023-06-07
JP2023523760A5 JP2023523760A5 (https=) 2023-06-14
JP7832120B2 true JP7832120B2 (ja) 2026-03-17

Family

ID=75787171

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022565970A Active JP7832120B2 (ja) 2020-05-01 2021-04-29 免疫グロブリン変異体
JP2025200590A Pending JP2026048674A (ja) 2020-05-01 2025-11-20 免疫グロブリン変異体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025200590A Pending JP2026048674A (ja) 2020-05-01 2025-11-20 免疫グロブリン変異体

Country Status (5)

Country Link
US (1) US20230167193A1 (https=)
EP (1) EP4143224A1 (https=)
JP (2) JP7832120B2 (https=)
CN (1) CN115461363A (https=)
WO (1) WO2021220218A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
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JP2008505174A (ja) 2004-07-15 2008-02-21 ゼンコー・インコーポレイテッド 最適化Ｆｃ変異体
US20150266960A1 (en) 2012-10-23 2015-09-24 The Board Of Regents Of The University Of Texas System Antibodies with engineered igg fc domains
US20190309085A1 (en) 2016-07-06 2019-10-10 Laboratoire Français Du Fractionnement Et Des Biotechnologies Fc mutants with improved functional activity

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JP2008505174A (ja) 2004-07-15 2008-02-21 ゼンコー・インコーポレイテッド 最適化Ｆｃ変異体
US20150266960A1 (en) 2012-10-23 2015-09-24 The Board Of Regents Of The University Of Texas System Antibodies with engineered igg fc domains
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Also Published As

Publication number Publication date
EP4143224A1 (en) 2023-03-08
JP2026048674A (ja) 2026-03-17
JP2023523760A (ja) 2023-06-07
WO2021220218A1 (en) 2021-11-04
CN115461363A (zh) 2022-12-09
US20230167193A1 (en) 2023-06-01

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