JP7809362B2 - 凍結乾燥生ボルデテラワクチン - Google Patents

凍結乾燥生ボルデテラワクチン

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Publication number
JP7809362B2
JP7809362B2 JP2023510359A JP2023510359A JP7809362B2 JP 7809362 B2 JP7809362 B2 JP 7809362B2 JP 2023510359 A JP2023510359 A JP 2023510359A JP 2023510359 A JP2023510359 A JP 2023510359A JP 7809362 B2 JP7809362 B2 JP 7809362B2
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Prior art keywords
bpze1
bordetella
lyophilization
lyophilized
bacteria
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JP2023510359A
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English (en)
Japanese (ja)
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JP2023540453A (ja
JP2023540453A5 (enExample
Inventor
ターレン，マルセル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ILIAD BIOTECHNOLOGIES LLC
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ILIAD BIOTECHNOLOGIES LLC
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Publication of JP2023540453A publication Critical patent/JP2023540453A/ja
Publication of JP2023540453A5 publication Critical patent/JP2023540453A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2023510359A 2020-08-14 2021-08-15 凍結乾燥生ボルデテラワクチン Active JP7809362B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063066020P 2020-08-14 2020-08-14
US63/066,020 2020-08-14
PCT/US2021/046055 WO2022036298A1 (en) 2020-08-14 2021-08-15 Lyophilized live bordetella vaccines

Publications (3)

Publication Number Publication Date
JP2023540453A JP2023540453A (ja) 2023-09-25
JP2023540453A5 JP2023540453A5 (enExample) 2024-06-27
JP7809362B2 true JP7809362B2 (ja) 2026-02-02

Family

ID=80247370

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023510359A Active JP7809362B2 (ja) 2020-08-14 2021-08-15 凍結乾燥生ボルデテラワクチン

Country Status (12)

Country Link
US (1) US20230173053A1 (enExample)
EP (1) EP4196155A4 (enExample)
JP (1) JP7809362B2 (enExample)
KR (1) KR20230051186A (enExample)
CN (1) CN116322756A (enExample)
AU (1) AU2021325149A1 (enExample)
BR (1) BR112023002549A2 (enExample)
CA (1) CA3187934A1 (enExample)
CL (1) CL2023000451A1 (enExample)
CO (1) CO2023002823A2 (enExample)
MX (1) MX2023001905A (enExample)
WO (1) WO2022036298A1 (enExample)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007517888A (ja) 2004-01-15 2007-07-05 インターベツト・インターナシヨナル・ベー・ベー 非動物由来安定剤およびその製造方法
JP2009529338A (ja) 2006-03-10 2009-08-20 アンスティテュ パストゥール ドゥ リル 百日咳に対する単一用量ワクチンとしての生弱毒化ボルデテラ株
JP2016531859A (ja) 2013-09-27 2016-10-13 インターベット インターナショナル ベー． フェー． 室温安定であるワクチンの乾燥製剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2215033C2 (ru) * 2001-06-27 2003-10-27 Научно-исследовательский институт микробиологии МО РФ Способ получения концентрата микробных клеток в производстве чумных вакцин
EP2722338A1 (en) 2012-10-17 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel recombinant Bordetella strains
EP4541809A3 (en) 2016-03-29 2025-06-25 Institut Pasteur de Lille Mutant bordetella strains and methods of use
RU2709657C2 (ru) * 2017-08-07 2019-12-19 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "НИЦЭМ им. Н.Ф. Гамалеи" Минздрава России) Способ лиофильного высушивания аттенуированных бактерий B. pertussis, аттенуированная бактерия B. pertussis, штамм аттенуированных бактерий B. Pertussis, вакцина, лиофилизированный вакцинный препарат
WO2020049133A1 (en) 2018-09-05 2020-03-12 National University Of Singapore Adenylate cyclase catalytic domain deficient bordetella strains

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007517888A (ja) 2004-01-15 2007-07-05 インターベツト・インターナシヨナル・ベー・ベー 非動物由来安定剤およびその製造方法
JP2009529338A (ja) 2006-03-10 2009-08-20 アンスティテュ パストゥール ドゥ リル 百日咳に対する単一用量ワクチンとしての生弱毒化ボルデテラ株
JP2016531859A (ja) 2013-09-27 2016-10-13 インターベット インターナショナル ベー． フェー． 室温安定であるワクチンの乾燥製剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JID，2017年，216，pp. 117-124，DOI: 10.1093/infdis/jix254
Пробл. особо опасных инф.(Problemy OsoboOpasnykh Infektsii, Problem of particularly dangerous infections)，2016年，3，pp. 5-12，DOI: 10.21055/0370-1069-2016-3-5-12
ロシア国特許第２７０９６５７号（C2)，2019年12月19日

Also Published As

Publication number Publication date
US20230173053A1 (en) 2023-06-08
CA3187934A1 (en) 2022-02-17
WO2022036298A1 (en) 2022-02-17
JP2023540453A (ja) 2023-09-25
AU2021325149A1 (en) 2023-03-02
CN116322756A (zh) 2023-06-23
CL2023000451A1 (es) 2023-10-20
EP4196155A1 (en) 2023-06-21
KR20230051186A (ko) 2023-04-17
MX2023001905A (es) 2023-03-13
EP4196155A4 (en) 2025-03-19
CO2023002823A2 (es) 2023-03-27
BR112023002549A2 (pt) 2023-03-07

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