JP7796376B2 - 牛乳アレルギーの新規抗原 - Google Patents

牛乳アレルギーの新規抗原

Info

Publication number
JP7796376B2
JP7796376B2 JP2021061611A JP2021061611A JP7796376B2 JP 7796376 B2 JP7796376 B2 JP 7796376B2 JP 2021061611 A JP2021061611 A JP 2021061611A JP 2021061611 A JP2021061611 A JP 2021061611A JP 7796376 B2 JP7796376 B2 JP 7796376B2
Authority
JP
Japan
Prior art keywords
amino acid
antigen
milk
acid sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021061611A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022157411A (ja
Inventor
佳世子 松永
晶子 矢上
康人 近藤
祐治 青木
英里香 長谷川
智美 酒井
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujita Health University
Original Assignee
Fujita Health University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujita Health University filed Critical Fujita Health University
Priority to JP2021061611A priority Critical patent/JP7796376B2/ja
Priority to EP22165219.1A priority patent/EP4080217A3/en
Priority to KR1020220038597A priority patent/KR20220136215A/ko
Priority to US17/708,653 priority patent/US20220323575A1/en
Priority to CN202210335973.5A priority patent/CN115144583A/zh
Publication of JP2022157411A publication Critical patent/JP2022157411A/ja
Priority to JP2025037736A priority patent/JP2025093999A/ja
Application granted granted Critical
Publication of JP7796376B2 publication Critical patent/JP7796376B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C7/00—Other dairy technology
    • A23C7/04—Removing unwanted substances other than lactose or milk proteins from milk
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Rehabilitation Therapy (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Endocrinology (AREA)
JP2021061611A 2021-03-31 2021-03-31 牛乳アレルギーの新規抗原 Active JP7796376B2 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2021061611A JP7796376B2 (ja) 2021-03-31 2021-03-31 牛乳アレルギーの新規抗原
EP22165219.1A EP4080217A3 (en) 2021-03-31 2022-03-29 Milk allergy antigen
KR1020220038597A KR20220136215A (ko) 2021-03-31 2022-03-29 우유 알레르기의 신규 항원
US17/708,653 US20220323575A1 (en) 2021-03-31 2022-03-30 Novel milk allergy antigen
CN202210335973.5A CN115144583A (zh) 2021-03-31 2022-03-31 牛奶变态反应的新抗原
JP2025037736A JP2025093999A (ja) 2021-03-31 2025-03-10 牛乳アレルギーの新規抗原

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2021061611A JP7796376B2 (ja) 2021-03-31 2021-03-31 牛乳アレルギーの新規抗原

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025037736A Division JP2025093999A (ja) 2021-03-31 2025-03-10 牛乳アレルギーの新規抗原

Publications (2)

Publication Number Publication Date
JP2022157411A JP2022157411A (ja) 2022-10-14
JP7796376B2 true JP7796376B2 (ja) 2026-01-09

Family

ID=81385106

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021061611A Active JP7796376B2 (ja) 2021-03-31 2021-03-31 牛乳アレルギーの新規抗原
JP2025037736A Pending JP2025093999A (ja) 2021-03-31 2025-03-10 牛乳アレルギーの新規抗原

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025037736A Pending JP2025093999A (ja) 2021-03-31 2025-03-10 牛乳アレルギーの新規抗原

Country Status (5)

Country Link
US (1) US20220323575A1 (https=)
EP (1) EP4080217A3 (https=)
JP (2) JP7796376B2 (https=)
KR (1) KR20220136215A (https=)
CN (1) CN115144583A (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2026049447A (ja) * 2024-09-06 2026-03-18 国立大学法人金沢大学 牛乳アレルギー検査のためのデバイス、キット、及び方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004033171A (ja) 2002-07-08 2004-02-05 Earth Work:Kk 根系通気灌水システム
US20090111702A1 (en) 2004-04-06 2009-04-30 Mount Sinai School Of Medicine Office Of Industrial Liason Methods of determining allergen response using microarray immunoassay techniques
WO2010052939A1 (ja) 2008-11-10 2010-05-14 国立大学法人名古屋大学 アレルゲンのエピトープ又はその候補の検出方法及びその利用
WO2015048339A2 (en) 2013-09-25 2015-04-02 Pronutria, Inc. Compositions and formulations for non-human nutrition and methods of production and use thereof
WO2018198430A1 (ja) 2016-06-16 2018-11-01 学校法人藤田学園 アレルギーの抗原およびそのエピトープ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4578709B2 (ja) 2001-03-28 2010-11-10 三菱化学メディエンス株式会社 複数項目同時分析可能なイムノクロマトグラフ法及びイムノクロマトグラフ用ストリップ
US8859210B2 (en) * 2008-10-17 2014-10-14 Mead Johnson Nutrition Company Method for identifying allergenic proteins and peptides
JP5513802B2 (ja) 2009-08-04 2014-06-04 ホーユー株式会社 等電点電気泳動用ゲル及び等電点電気泳動方法
JP5475358B2 (ja) 2009-08-04 2014-04-16 ホーユー株式会社 ２次元電気泳動方法
JP5433341B2 (ja) 2009-08-04 2014-03-05 ホーユー株式会社 等電点電気泳動方法及び粗雑物除去の判定方法
JP5190423B2 (ja) 2009-08-04 2013-04-24 ホーユー株式会社 ２次元電気泳動方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004033171A (ja) 2002-07-08 2004-02-05 Earth Work:Kk 根系通気灌水システム
US20090111702A1 (en) 2004-04-06 2009-04-30 Mount Sinai School Of Medicine Office Of Industrial Liason Methods of determining allergen response using microarray immunoassay techniques
WO2010052939A1 (ja) 2008-11-10 2010-05-14 国立大学法人名古屋大学 アレルゲンのエピトープ又はその候補の検出方法及びその利用
WO2015048339A2 (en) 2013-09-25 2015-04-02 Pronutria, Inc. Compositions and formulations for non-human nutrition and methods of production and use thereof
WO2018198430A1 (ja) 2016-06-16 2018-11-01 学校法人藤田学園 アレルギーの抗原およびそのエピトープ
US20190256566A1 (en) 2016-06-16 2019-08-22 Hoyu Co., Ltd. Fish allergy antigen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Marija Perusko，Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome，Allergy，2021年05月03日，Vol.76，Page.3766-3775
近藤康人，食物アレルギー 解説 食物アレルゲンコンポーネント，栄養，2017年12月30日，Vol.2 No.4，Page.215-223
青木祐治，牛乳アレルギー36例の網羅的抗原解析から得られた19種のタンパク質の有用性，アレルギー，2021年08月20日，Vol.70 No.6/7，Page.826
高松伸枝，加工食品中に微量に含まれる抗原タンパク質の測定，日本小児アレルギー学会誌，2023年10月06日，Vol.37 No.4，Page.360

Also Published As

Publication number Publication date
EP4080217A2 (en) 2022-10-26
JP2022157411A (ja) 2022-10-14
JP2025093999A (ja) 2025-06-24
EP4080217A3 (en) 2022-12-28
KR20220136215A (ko) 2022-10-07
US20220323575A1 (en) 2022-10-13
CN115144583A (zh) 2022-10-04

Similar Documents

Publication Publication Date Title
JP7834292B2 (ja) アレルギーの抗原およびそのエピトープ
JP7470934B2 (ja) アレルギーの抗原およびそのエピトープ
JP2025118770A (ja) アレルギーの抗原およびそのエピトープ
CN111051336B (zh) 变态反应的抗原及其表位
JP2025093999A (ja) 牛乳アレルギーの新規抗原
KR102102031B1 (ko) 메추리알 알레르기의 항원
US20210231678A1 (en) Allergy antigen and epitope thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220517

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240228

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20240529

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20240529

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20240604

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20240830

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240903

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20241025

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20241217

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250310

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250708

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250828

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20251118

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20251215

R150 Certificate of patent or registration of utility model

Ref document number: 7796376

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150