JP7783436B2 - Ｐａｒｇ阻害剤としてのピペラジン置換インダゾール化合物 - Google Patents

Ｐａｒｇ阻害剤としてのピペラジン置換インダゾール化合物

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Publication number
JP7783436B2
JP7783436B2 JP2024556141A JP2024556141A JP7783436B2 JP 7783436 B2 JP7783436 B2 JP 7783436B2 JP 2024556141 A JP2024556141 A JP 2024556141A JP 2024556141 A JP2024556141 A JP 2024556141A JP 7783436 B2 JP7783436 B2 JP 7783436B2
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cancer
formula
pharmaceutically acceptable
pharmaceutical composition
acceptable salt
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JP2025512780A5 (https=
JP2025512780A (ja
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エー．バルサンティ ポール
パトリック ディロン マイケル
アリ ジャイプリ フィロズ
シュイ イン－ツー
リンフー シン
アベド モナ
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アイディアヤ バイオサイエンシーズ，インコーポレイティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2024556141A 2022-03-23 2023-03-22 Ｐａｒｇ阻害剤としてのピペラジン置換インダゾール化合物 Active JP7783436B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263322994P 2022-03-23 2022-03-23
US63/322,994 2022-03-23
PCT/US2023/064825 WO2023183850A1 (en) 2022-03-23 2023-03-22 Piperazine substituted indazole compounds as inhibitors of parg

Publications (3)

Publication Number Publication Date
JP2025512780A JP2025512780A (ja) 2025-04-22
JP2025512780A5 JP2025512780A5 (https=) 2025-08-14
JP7783436B2 true JP7783436B2 (ja) 2025-12-09

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JP2024556141A Active JP7783436B2 (ja) 2022-03-23 2023-03-22 Ｐａｒｇ阻害剤としてのピペラジン置換インダゾール化合物

Country Status (17)

Country Link
US (2) US12269820B2 (https=)
EP (1) EP4496795B1 (https=)
JP (1) JP7783436B2 (https=)
KR (1) KR20240165402A (https=)
CN (1) CN119255994A (https=)
AR (1) AR128846A1 (https=)
AU (1) AU2023239344A1 (https=)
CA (1) CA3245542A1 (https=)
CL (1) CL2024002805A1 (https=)
CO (1) CO2024012798A2 (https=)
CR (1) CR20240391A (https=)
DO (1) DOP2024000187A (https=)
IL (1) IL315722A (https=)
MX (1) MX2024011545A (https=)
PE (1) PE20251690A1 (https=)
TW (1) TW202345809A (https=)
WO (1) WO2023183850A1 (https=)

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MX2024011545A (es) 2022-03-23 2024-09-26 Ideaya Biosciences Inc Compuestos de indazol sustituidos con piperazina como inhibidores de parg.
AU2024253809A1 (en) * 2023-04-05 2025-10-16 Ideaya Biosciences, Inc. Combination therapy comprising a parg inhibitor and a topoisomerase inhibitor for treating cancer
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TW202528308A (zh) * 2023-09-20 2025-07-16 美商愛德亞生物科學公司 Parg抑制劑
WO2025064750A1 (en) * 2023-09-20 2025-03-27 Ideaya Biosciences, Inc. Combination therapy with a parg inhibitor
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WO2025087941A1 (en) 2023-10-23 2025-05-01 Universite De Geneve Parg inhibitors in combination with parp inhibitors and uses thereof
WO2025087409A1 (zh) * 2023-10-26 2025-05-01 上海齐鲁制药研究中心有限公司 Parg抑制剂
WO2026022150A1 (en) 2024-07-22 2026-01-29 Forx Therapeutics Ag Parg inhibitory compounds
WO2026026739A1 (zh) * 2024-07-29 2026-02-05 海思科医药集团股份有限公司 一种磺酰胺化合物及其在医药上的应用
WO2026032385A1 (zh) * 2024-08-07 2026-02-12 上海亚虹医药科技有限公司 多聚adp核糖水解酶抑制剂及其医药用途
WO2026062066A1 (en) 2024-09-17 2026-03-26 Forx Therapeutics Ag Compounds inducing parg degradation

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Also Published As

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US20250376467A1 (en) 2025-12-11
IL315722A (en) 2024-11-01
AU2023239344A1 (en) 2024-10-10
PE20251690A1 (es) 2025-07-02
CO2024012798A2 (es) 2024-10-21
AR128846A1 (es) 2024-06-19
CN119255994A (zh) 2025-01-03
DOP2024000187A (es) 2024-12-30
MX2024011545A (es) 2024-09-26
CR20240391A (es) 2024-11-05
US20230303556A1 (en) 2023-09-28
JP2025512780A (ja) 2025-04-22
KR20240165402A (ko) 2024-11-22
CA3245542A1 (en) 2023-09-28
US12269820B2 (en) 2025-04-08
TW202345809A (zh) 2023-12-01
WO2023183850A1 (en) 2023-09-28
EP4496795B1 (en) 2026-04-01
EP4496795A1 (en) 2025-01-29
CL2024002805A1 (es) 2025-05-09

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