TW202345809A - 作為parg抑制劑之經哌取代的吲唑化合物 - Google Patents
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Classifications
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
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- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| JP2022548690A (ja) * | 2019-09-20 | 2022-11-21 | アイディアヤ バイオサイエンシーズ，インコーポレイティド | Ｐａｒｇ阻害剤としての４－置換インドールおよびインダゾールスルホンアミド誘導体 |
| MX2024011545A (es) | 2022-03-23 | 2024-09-26 | Ideaya Biosciences Inc | Compuestos de indazol sustituidos con piperazina como inhibidores de parg. |
| AU2024253809A1 (en) * | 2023-04-05 | 2025-10-16 | Ideaya Biosciences, Inc. | Combination therapy comprising a parg inhibitor and a topoisomerase inhibitor for treating cancer |
| WO2025046148A1 (en) | 2023-09-01 | 2025-03-06 | Forx Therapeutics Ag | Novel parg inhibitors |
| TW202528308A (zh) * | 2023-09-20 | 2025-07-16 | 美商愛德亞生物科學公司 | Parg抑制劑 |
| WO2025064750A1 (en) * | 2023-09-20 | 2025-03-27 | Ideaya Biosciences, Inc. | Combination therapy with a parg inhibitor |
| CN119859145A (zh) * | 2023-10-20 | 2025-04-22 | 上海璎黎药业有限公司 | 一种杂芳环磺酰胺结构化合物、其药物组合物及应用 |
| WO2025087941A1 (en) | 2023-10-23 | 2025-05-01 | Universite De Geneve | Parg inhibitors in combination with parp inhibitors and uses thereof |
| WO2025087409A1 (zh) * | 2023-10-26 | 2025-05-01 | 上海齐鲁制药研究中心有限公司 | Parg抑制剂 |
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| WO2026026739A1 (zh) * | 2024-07-29 | 2026-02-05 | 海思科医药集团股份有限公司 | 一种磺酰胺化合物及其在医药上的应用 |
| WO2026032385A1 (zh) * | 2024-08-07 | 2026-02-12 | 上海亚虹医药科技有限公司 | 多聚adp核糖水解酶抑制剂及其医药用途 |
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| WO2024173453A1 (en) | 2023-02-14 | 2024-08-22 | Ideaya Biosciences, Inc. | Heteroaryl-substituted imidazopyridine compounds |
| WO2024173514A1 (en) | 2023-02-14 | 2024-08-22 | Ideaya Biosciences, Inc. | Amide and ester-substituted imidazopyridine compounds |
| WO2024173530A1 (en) | 2023-02-14 | 2024-08-22 | Ideaya Biosciences, Inc. | Heteroaryl-substituted pyrazolo/imidazo pyridine compounds |
| WO2024173524A1 (en) | 2023-02-14 | 2024-08-22 | Ideaya Biosciences, Inc. | Heteroaryl-substituted benzimidazole compounds |
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2023
- 2023-03-22 MX MX2024011545A patent/MX2024011545A/es unknown
- 2023-03-22 TW TW112110751A patent/TW202345809A/zh unknown
- 2023-03-22 WO PCT/US2023/064825 patent/WO2023183850A1/en not_active Ceased
- 2023-03-22 CA CA3245542A patent/CA3245542A1/en active Pending
- 2023-03-22 CR CR20240391A patent/CR20240391A/es unknown
- 2023-03-22 IL IL315722A patent/IL315722A/en unknown
- 2023-03-22 CN CN202380042074.9A patent/CN119255994A/zh active Pending
- 2023-03-22 AR ARP230100697A patent/AR128846A1/es unknown
- 2023-03-22 JP JP2024556141A patent/JP7783436B2/ja active Active
- 2023-03-22 US US18/188,278 patent/US12269820B2/en active Active
- 2023-03-22 AU AU2023239344A patent/AU2023239344A1/en active Pending
- 2023-03-22 EP EP23718143.3A patent/EP4496795B1/en active Active
- 2023-03-22 PE PE2024002037A patent/PE20251690A1/es unknown
- 2023-03-22 KR KR1020247034606A patent/KR20240165402A/ko active Pending
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2024
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2025
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| US20250376467A1 (en) | 2025-12-11 |
| IL315722A (en) | 2024-11-01 |
| AU2023239344A1 (en) | 2024-10-10 |
| PE20251690A1 (es) | 2025-07-02 |
| CO2024012798A2 (es) | 2024-10-21 |
| AR128846A1 (es) | 2024-06-19 |
| CN119255994A (zh) | 2025-01-03 |
| DOP2024000187A (es) | 2024-12-30 |
| MX2024011545A (es) | 2024-09-26 |
| CR20240391A (es) | 2024-11-05 |
| JP7783436B2 (ja) | 2025-12-09 |
| US20230303556A1 (en) | 2023-09-28 |
| JP2025512780A (ja) | 2025-04-22 |
| KR20240165402A (ko) | 2024-11-22 |
| CA3245542A1 (en) | 2023-09-28 |
| US12269820B2 (en) | 2025-04-08 |
| WO2023183850A1 (en) | 2023-09-28 |
| EP4496795B1 (en) | 2026-04-01 |
| EP4496795A1 (en) | 2025-01-29 |
| CL2024002805A1 (es) | 2025-05-09 |
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