JP7773981B2 - 新型ポリペプチド複合物 - Google Patents

新型ポリペプチド複合物

Info

Publication number
JP7773981B2
JP7773981B2 JP2022542256A JP2022542256A JP7773981B2 JP 7773981 B2 JP7773981 B2 JP 7773981B2 JP 2022542256 A JP2022542256 A JP 2022542256A JP 2022542256 A JP2022542256 A JP 2022542256A JP 7773981 B2 JP7773981 B2 JP 7773981B2
Authority
JP
Japan
Prior art keywords
chain
seq
sequence
obscurin
titin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022542256A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023509212A5 (https=
JP2023509212A (ja
JPWO2021139758A5 (https=
Inventor
華 応
斉悦 胡
玲 張
浪勇 毛
金平 石
▲ティン▼▲ティン▼ 黎
▲ウェイ▼明 頼
千山 覃
薪盛 金
維康 陶
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Shanghai Hengrui Pharmaceutical Co Ltd
Publication of JP2023509212A publication Critical patent/JP2023509212A/ja
Publication of JP2023509212A5 publication Critical patent/JP2023509212A5/ja
Publication of JPWO2021139758A5 publication Critical patent/JPWO2021139758A5/ja
Application granted granted Critical
Publication of JP7773981B2 publication Critical patent/JP7773981B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022542256A 2020-01-09 2021-01-08 新型ポリペプチド複合物 Active JP7773981B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010020878 2020-01-09
CN202010020878.7 2020-01-09
PCT/CN2021/070832 WO2021139758A1 (zh) 2020-01-09 2021-01-08 新型多肽复合物

Publications (4)

Publication Number Publication Date
JP2023509212A JP2023509212A (ja) 2023-03-07
JP2023509212A5 JP2023509212A5 (https=) 2024-01-16
JPWO2021139758A5 JPWO2021139758A5 (https=) 2024-01-16
JP7773981B2 true JP7773981B2 (ja) 2025-11-20

Family

ID=76787741

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022542256A Active JP7773981B2 (ja) 2020-01-09 2021-01-08 新型ポリペプチド複合物

Country Status (9)

Country Link
US (1) US20230120270A1 (https=)
EP (1) EP4089111A4 (https=)
JP (1) JP7773981B2 (https=)
KR (1) KR20220123072A (https=)
CN (1) CN114746440B (https=)
AU (1) AU2021205561A1 (https=)
CA (1) CA3164979A1 (https=)
TW (1) TWI878430B (https=)
WO (1) WO2021139758A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3981788A4 (en) 2019-06-04 2023-03-22 Jiangsu Hengrui Medicine Co., Ltd. ANTIBODY CAPABLE OF BINDING THYMIC STROMAL LYMPHOPOIETIN AND ITS USE
MX2023006596A (es) * 2020-12-03 2023-06-19 Jiangsu Hengrui Pharmaceuticals Co Ltd Composicion farmaceutica de anticuerpo anti-tslp y uso de la misma.
TW202317635A (zh) * 2021-07-14 2023-05-01 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合ｈｇｆｒ和ｅｇｆｒ的抗原結合分子及其醫藥用途
WO2023147784A1 (zh) 2022-02-07 2023-08-10 江苏恒瑞医药股份有限公司 特异性结合psma和cd3的抗原结合分子及其医药用途
CN118660910A (zh) 2022-03-14 2024-09-17 江苏恒瑞医药股份有限公司 特异性结合gprc5d和cd3的抗原结合分子及其医药用途
TW202405015A (zh) * 2022-04-11 2024-02-01 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合ｐｓｍａ和ｃｄ２８的抗原結合分子及其醫藥用途
TW202413416A (zh) * 2022-04-11 2024-04-01 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合ｅｇｆｒ和ｃｄ２８的抗原結合分子及其醫藥用途
EP4545564A4 (en) * 2022-06-23 2026-01-14 Jiangsu Hengrui Pharmaceuticals Co Ltd Antigen-binding molecule specifically binding to DLL3 and CD3, and its pharmaceutical use
TW202413437A (zh) 2022-08-05 2024-04-01 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合ｇｕｃｙ２ｃ和ｃｄ３的抗原結合分子及其醫藥用途
WO2024131864A1 (zh) * 2022-12-21 2024-06-27 广东菲鹏制药股份有限公司 一种il-10单体融合蛋白
CN121712807A (zh) 2023-08-31 2026-03-20 江苏恒瑞医药股份有限公司 Ctla4/tigit结合蛋白及其医药用途
WO2025082377A1 (zh) * 2023-10-17 2025-04-24 江苏恒瑞医药股份有限公司 一种抗tslp抗体的药物组合物及其用途
WO2025106278A1 (en) 2023-11-17 2025-05-22 Mersana Therapeutics, Inc. Treatment of cancer using b7-h4-targeted antibody-drug conjugates

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009525462A (ja) 2005-12-15 2009-07-09 ベクトン・ディキンソン・アンド・カンパニー 敗血症の診断
JP2010525822A (ja) 2007-05-01 2010-07-29 ユニバーシティ オブ マイアミ 新規に進行中の心不全における個人のリスク評価のためのトランスクリプトームのバイオマーカー
JP2016500511A (ja) 2012-09-14 2016-01-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 少なくとも２つの異なる実体を含む分子を作製および選択するための方法ならびにその使用
JP2017521361A (ja) 2014-05-16 2017-08-03 ファイザー・インク 二重特異性抗体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5889151A (en) 1989-10-20 1999-03-30 Societe Leb-Tech Purified human alpha interferon receptor
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
WO2007062037A2 (en) * 2005-11-21 2007-05-31 Laboratoires Serono Sa Compositions and methods of producing hybrid antigen binding molecules and uses thereof
WO2012142159A2 (en) * 2011-04-11 2012-10-18 The Brigham And Women's Hospital, Inc Structural mutations in titin cause dilated cardiomyopathy
WO2014014796A1 (en) * 2012-07-18 2014-01-23 Eli Lilly And Company Multi-specific igg-(fab)2 constructs containing t-cell receptor constant domains
CN108601830B (zh) * 2015-12-18 2023-02-03 比奥根Ma公司 双特异性抗体平台
CN117843810A (zh) 2017-09-22 2024-04-09 上海药明生物技术有限公司 新型双特异性多肽复合物
CN109970860A (zh) * 2017-12-27 2019-07-05 信达生物制药(苏州)有限公司 三链抗体、其制备方法及其用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009525462A (ja) 2005-12-15 2009-07-09 ベクトン・ディキンソン・アンド・カンパニー 敗血症の診断
JP2010525822A (ja) 2007-05-01 2010-07-29 ユニバーシティ オブ マイアミ 新規に進行中の心不全における個人のリスク評価のためのトランスクリプトームのバイオマーカー
JP2016500511A (ja) 2012-09-14 2016-01-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 少なくとも２つの異なる実体を含む分子を作製および選択するための方法ならびにその使用
JP2017521361A (ja) 2014-05-16 2017-08-03 ファイザー・インク 二重特異性抗体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Pernigo, S. et al.，The Crystal Structure of the Human Titin: Obscurin Complex Reveals a Conserved yet Specific Muscle M-Band Zipper Module，J. Mol. Biol.，2015年，vol.427，p.718-736

Also Published As

Publication number Publication date
EP4089111A4 (en) 2023-10-04
KR20220123072A (ko) 2022-09-05
CA3164979A1 (en) 2021-07-15
JP2023509212A (ja) 2023-03-07
US20230120270A1 (en) 2023-04-20
WO2021139758A1 (zh) 2021-07-15
TWI878430B (zh) 2025-04-01
TW202128770A (zh) 2021-08-01
CN114746440A (zh) 2022-07-12
EP4089111A1 (en) 2022-11-16
CN114746440B (zh) 2024-11-15
AU2021205561A1 (en) 2022-08-11

Similar Documents

Publication Publication Date Title
JP7773981B2 (ja) 新型ポリペプチド複合物
CN107614529B (zh) Pd-l1抗体、其抗原结合片段及其医药用途
KR101517320B1 (ko) 단일특이적 및 이중특이적 항-igf-1r 및 항 erbb3 항체
CN110256569B (zh) 具有交换结合区取向的双重可变区抗体样结合蛋白
JP7257971B2 (ja) 抗ｃｄ４０抗体、その抗原結合フラグメント、およびその医学的使用
IL285101B1 (en) G protein-coupled receptor-directed antibodies and methods of use
JP7538131B2 (ja) 抗ｃｄ７９ｂ抗体、その抗原結合フラグメントおよびそれらの医薬用途
CN113227148B (zh) 抗gpc3抗体、其抗原结合片段及其医药用途
JP2024517907A (ja) 抗原結合分子
CN115558023A (zh) 抗cd3抗体及其用途
WO2024017326A1 (zh) 抗gprc5d纳米抗体及其应用
JP7808306B2 (ja) 抗ｃｄ３ヒト化抗体
JP7804295B2 (ja) 二機能性融合タンパク質およびその用途
JP2024543134A (ja) 修飾されたタンパク質又はポリペプチド
JP2025526279A (ja) 抗ＴＮＦα抗体および組成物
RU2847355C1 (ru) Новый полипептидный комплекс
HK40076302B (zh) 新型多肽复合物
HK40076302A (en) New polypeptide complex
RU2824193C2 (ru) Антигенсвязывающие полипептидные конструкции, содержащие легкие цепи каппа и лямбда, и их применения
TW202528360A (zh) 藉由重組反應製備異源多聚體的方法
KR20240022546A (ko) 항il-36r 항체 및 그의 사용
HK40106257A (zh) 新型抗sirpa抗体
CN119013294A (zh) Zip12抗体2
HK40049006B (en) Anti-gpc3 antibody, antigen-binding fragment thereof, and medical use thereof
HK40049006A (en) Anti-gpc3 antibody, antigen-binding fragment thereof, and medical use thereof

Legal Events

Date Code Title Description
RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20231222

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240105

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240105

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20241224

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250324

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250430

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250731

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20251014

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20251110

R150 Certificate of patent or registration of utility model

Ref document number: 7773981

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150