JP7756072B2 - Ｔ細胞調節ポリペプチド及びその使用方法 - Google Patents

Ｔ細胞調節ポリペプチド及びその使用方法

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Publication number
JP7756072B2
JP7756072B2 JP2022506595A JP2022506595A JP7756072B2 JP 7756072 B2 JP7756072 B2 JP 7756072B2 JP 2022506595 A JP2022506595 A JP 2022506595A JP 2022506595 A JP2022506595 A JP 2022506595A JP 7756072 B2 JP7756072 B2 JP 7756072B2
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seq
polypeptide
amino acid
tmp
acid sequence
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Japanese (ja)
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JP2022548472A (ja
JP2022548472A5 (enExample
Inventor
ザ サード ロナルド ディー． セイデル
ロドルフォ ジェイ． チャパーロ
ジョン エフ． ロス
サソ チェメルスキ
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キュー バイオファーマ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2022506595A 2019-09-20 2020-09-17 Ｔ細胞調節ポリペプチド及びその使用方法 Active JP7756072B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962903441P 2019-09-20 2019-09-20
US62/903,441 2019-09-20
US202062990693P 2020-03-17 2020-03-17
US62/990,693 2020-03-17
US202063048561P 2020-07-06 2020-07-06
US63/048,561 2020-07-06
PCT/US2020/051255 WO2021055594A1 (en) 2019-09-20 2020-09-17 T-cell modulatory polypeptides and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2022548472A JP2022548472A (ja) 2022-11-21
JP2022548472A5 JP2022548472A5 (enExample) 2023-09-25
JP7756072B2 true JP7756072B2 (ja) 2025-10-17

Family

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JP2022506595A Active JP7756072B2 (ja) 2019-09-20 2020-09-17 Ｔ細胞調節ポリペプチド及びその使用方法

Country Status (11)

Country Link
US (2) US20220143063A1 (enExample)
EP (1) EP4030897A4 (enExample)
JP (1) JP7756072B2 (enExample)
KR (1) KR20220066075A (enExample)
CN (1) CN114423284A (enExample)
AU (1) AU2020348373A1 (enExample)
CA (1) CA3146591A1 (enExample)
IL (1) IL290635A (enExample)
MX (1) MX2022003367A (enExample)
TW (1) TW202126683A (enExample)
WO (1) WO2021055594A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110325205B (zh) 2016-12-22 2023-08-15 库尔生物制药有限公司 T细胞调节性多聚体多肽及其使用方法
KR20240005989A (ko) 2017-03-15 2024-01-12 큐 바이오파마, 인크. 면역 반응을 조절하는 방법
WO2019051127A1 (en) 2017-09-07 2019-03-14 Cue Biopharma, Inc. MULTIMER MODULATOR POLYPEPTIDE OF LYMPHOCYTE T HAVING CONJUGATION SITES AND METHODS OF USE THEREOF
TWI856047B (zh) * 2018-12-19 2024-09-21 美商信號生物製藥公司 多聚體ｔ細胞調節多肽及其使用方法
WO2021087840A1 (zh) * 2019-11-07 2021-05-14 武汉华大吉诺因生物科技有限公司 肿瘤免疫治疗多肽及其应用
IL296209A (en) 2020-05-12 2022-11-01 Cue Biopharma Inc Multimeric t-cell modulatory polypeptides and methods of using them
JP2023541366A (ja) 2020-09-09 2023-10-02 キュー バイオファーマ， インコーポレイテッド １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法
US11058751B1 (en) * 2020-11-20 2021-07-13 Think Therapeutics, Inc. Compositions for optimized RAS peptide vaccines
CN116710115A (zh) 2020-11-20 2023-09-05 思维疗法股份有限公司 用于优化的肽疫苗的组合物和方法
US11421015B2 (en) 2020-12-07 2022-08-23 Think Therapeutics, Inc. Method of compact peptide vaccines using residue optimization
WO2022140759A2 (en) * 2020-12-23 2022-06-30 Janssen Biotech, Inc. Neoantigen peptide mimics
EP4308143A4 (en) * 2021-03-19 2025-06-04 Cue Biopharma, Inc. T-cell modulatory polypeptides and methods of use thereof
US11464842B1 (en) 2021-04-28 2022-10-11 Think Therapeutics, Inc. Compositions and method for optimized peptide vaccines using residue optimization
EP4504802A4 (en) * 2022-04-07 2026-03-25 Cue Biopharma Inc IMMUNE CELL BINDING POLYPEPTIDES
CN115820736B (zh) * 2022-12-08 2024-05-10 西南大学 家蚕丝胶蛋白Ser4在提高蚕丝性能中的应用及其方法
WO2024264007A2 (en) * 2023-06-23 2024-12-26 Cue Biopharma, Inc. T-cell modulatory polypeptides and methods of use thereof
WO2024264004A2 (en) * 2023-06-23 2024-12-26 Cue Biopharma, Inc. T-cell modulatory polypeptides and methods of use thereof
WO2026125765A1 (en) 2024-12-13 2026-06-18 Immunoscape Pte. Ltd. Combination therapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017519491A (ja) 2014-06-18 2017-07-20 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ｓｙｎＴａｃポリペプチド及びその使用
JP2018513135A (ja) 2015-03-23 2018-05-24 ザ ジョンズ ホプキンス ユニバーシティー 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ
JP2019511458A (ja) 2016-01-27 2019-04-25 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト 組み換えＩｇＧ Ｆｃ多量体
WO2021230247A1 (ja) 2020-05-12 2021-11-18 大日本住友製薬株式会社 癌を処置するための医薬組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3014458A1 (en) * 2016-03-02 2017-09-08 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
WO2017151940A2 (en) * 2016-03-03 2017-09-08 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
SG11201808552XA (en) * 2016-05-18 2018-10-30 Cue Biopharma Inc T-cell modulatory multimeric polypeptides and methods of use thereof
CN110325205B (zh) * 2016-12-22 2023-08-15 库尔生物制药有限公司 T细胞调节性多聚体多肽及其使用方法
US11851471B2 (en) * 2017-01-09 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
KR20240005989A (ko) * 2017-03-15 2024-01-12 큐 바이오파마, 인크. 면역 반응을 조절하는 방법
WO2019051127A1 (en) * 2017-09-07 2019-03-14 Cue Biopharma, Inc. MULTIMER MODULATOR POLYPEPTIDE OF LYMPHOCYTE T HAVING CONJUGATION SITES AND METHODS OF USE THEREOF
WO2019139896A1 (en) * 2018-01-09 2019-07-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017519491A (ja) 2014-06-18 2017-07-20 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ｓｙｎＴａｃポリペプチド及びその使用
JP2018513135A (ja) 2015-03-23 2018-05-24 ザ ジョンズ ホプキンス ユニバーシティー 体細胞変異遺伝子によりコードされるｈｌａ拘束性エピトープ
JP2019511458A (ja) 2016-01-27 2019-04-25 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト 組み換えＩｇＧ Ｆｃ多量体
WO2021230247A1 (ja) 2020-05-12 2021-11-18 大日本住友製薬株式会社 癌を処置するための医薬組成物

Also Published As

Publication number Publication date
US20220143063A1 (en) 2022-05-12
EP4030897A4 (en) 2023-10-18
IL290635A (en) 2022-04-01
MX2022003367A (es) 2022-04-11
KR20220066075A (ko) 2022-05-23
WO2021055594A1 (en) 2021-03-25
EP4030897A1 (en) 2022-07-27
US20250120996A1 (en) 2025-04-17
CN114423284A (zh) 2022-04-29
CA3146591A1 (en) 2021-03-25
JP2022548472A (ja) 2022-11-21
AU2020348373A1 (en) 2022-02-24
TW202126683A (zh) 2021-07-16

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