JP7747337B2 - 速度論的光学分割のためのカルボキシエステラーゼポリペプチド - Google Patents

速度論的光学分割のためのカルボキシエステラーゼポリペプチド

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Publication number
JP7747337B2
JP7747337B2 JP2022561488A JP2022561488A JP7747337B2 JP 7747337 B2 JP7747337 B2 JP 7747337B2 JP 2022561488 A JP2022561488 A JP 2022561488A JP 2022561488 A JP2022561488 A JP 2022561488A JP 7747337 B2 JP7747337 B2 JP 7747337B2
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carboxylesterase
engineered
sequence
polypeptide
seq
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JP2023521972A5 (enExample
JP2023521972A (ja
Inventor
ラマ ボラドリ，
ジェシカ アンナ フルタク，
オーリック アンソニー ソーウェル－カンツ，
ナンディタ スブラマニアン，
エリカ バームデス，
デイビッド エントウィッスル，
メリッサ アン メイヨー，
ジェイムズ ニコラス リギンズ，
スコット ジェイ． ノヴィック，
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コデクシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • External Artificial Organs (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
JP2022561488A 2020-04-10 2021-04-06 速度論的光学分割のためのカルボキシエステラーゼポリペプチド Active JP7747337B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063008061P 2020-04-10 2020-04-10
US63/008,061 2020-04-10
PCT/US2021/025975 WO2021207208A1 (en) 2020-04-10 2021-04-06 Carboxyesterase polypeptides for kinetic resolution

Publications (3)

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JP2023521972A JP2023521972A (ja) 2023-05-26
JP2023521972A5 JP2023521972A5 (enExample) 2024-04-10
JP7747337B2 true JP7747337B2 (ja) 2025-10-01

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JP2022561488A Active JP7747337B2 (ja) 2020-04-10 2021-04-06 速度論的光学分割のためのカルボキシエステラーゼポリペプチド

Country Status (7)

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US (2) US12612605B2 (enExample)
EP (1) EP4133065A4 (enExample)
JP (1) JP7747337B2 (enExample)
CN (1) CN115397978A (enExample)
CA (1) CA3179679A1 (enExample)
IL (1) IL296983A (enExample)
WO (1) WO2021207208A1 (enExample)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
EP4234555A3 (en) * 2019-04-11 2024-01-03 Bristol-Myers Squibb Company Novel synthetic options towards the manufacture of (6r,10s)-10- {4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6h)- pyrimidinyl}- 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15 -(metheno)pyrazolo [4,3-b] [1,7] diazacyclotetradecin-5(6h)-one
CN115896065B (zh) * 2022-09-06 2023-08-11 江南大学 一种立体选择性羧酯酶、编码基因、载体及其应用

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WO2019118557A1 (en) 2017-12-13 2019-06-20 Codexis, Inc. Carboxyesterase polypeptides for amide coupling
WO2019116311A1 (en) 2017-12-13 2019-06-20 Glaxosmithkline Intellectual Property Development Limited Carboxyesterase biocatalysts

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WO2019118557A1 (en) 2017-12-13 2019-06-20 Codexis, Inc. Carboxyesterase polypeptides for amide coupling
WO2019116311A1 (en) 2017-12-13 2019-06-20 Glaxosmithkline Intellectual Property Development Limited Carboxyesterase biocatalysts

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Also Published As

Publication number Publication date
EP4133065A4 (en) 2024-07-10
US20260193626A1 (en) 2026-07-09
US12612605B2 (en) 2026-04-28
EP4133065A1 (en) 2023-02-15
CA3179679A1 (en) 2021-10-14
IL296983A (en) 2022-12-01
US20230159904A1 (en) 2023-05-25
CN115397978A (zh) 2022-11-25
WO2021207208A1 (en) 2021-10-14
JP2023521972A (ja) 2023-05-26

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