CN115397978A - 用于动力学拆分的羧酸酯酶多肽 - Google Patents

用于动力学拆分的羧酸酯酶多肽 Download PDF

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Publication number
CN115397978A
CN115397978A CN202180027593.9A CN202180027593A CN115397978A CN 115397978 A CN115397978 A CN 115397978A CN 202180027593 A CN202180027593 A CN 202180027593A CN 115397978 A CN115397978 A CN 115397978A
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carboxylesterase
engineered
sequence
ala
polypeptide
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CN202180027593.9A
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Chinese (zh)
Inventor
拉玛·沃兰德里
杰西卡·安娜·胡尔塔克
奥里克·安东尼·索厄尔-肯士
南希塔·苏布兰马尼安
埃里卡·贝穆德斯
大卫·恩特韦斯特尔
美利莎·安·梅奥
詹姆斯·尼古拉斯·里金斯
斯科特·J·诺维克
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Codexis Inc
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Codexis Inc
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Publication of CN115397978A publication Critical patent/CN115397978A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • External Artificial Organs (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
CN202180027593.9A 2020-04-10 2021-04-06 用于动力学拆分的羧酸酯酶多肽 Pending CN115397978A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063008061P 2020-04-10 2020-04-10
US63/008,061 2020-04-10
PCT/US2021/025975 WO2021207208A1 (en) 2020-04-10 2021-04-06 Carboxyesterase polypeptides for kinetic resolution

Publications (1)

Publication Number Publication Date
CN115397978A true CN115397978A (zh) 2022-11-25

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CN202180027593.9A Pending CN115397978A (zh) 2020-04-10 2021-04-06 用于动力学拆分的羧酸酯酶多肽

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US (2) US12612605B2 (enExample)
EP (1) EP4133065A4 (enExample)
JP (1) JP7747337B2 (enExample)
CN (1) CN115397978A (enExample)
CA (1) CA3179679A1 (enExample)
IL (1) IL296983A (enExample)
WO (1) WO2021207208A1 (enExample)

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Publication number Priority date Publication date Assignee Title
EP4234555A3 (en) * 2019-04-11 2024-01-03 Bristol-Myers Squibb Company Novel synthetic options towards the manufacture of (6r,10s)-10- {4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6h)- pyrimidinyl}- 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15 -(metheno)pyrazolo [4,3-b] [1,7] diazacyclotetradecin-5(6h)-one
CN115896065B (zh) * 2022-09-06 2023-08-11 江南大学 一种立体选择性羧酯酶、编码基因、载体及其应用

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EP4133065A4 (en) 2024-07-10
US20260193626A1 (en) 2026-07-09
US12612605B2 (en) 2026-04-28
JP7747337B2 (ja) 2025-10-01
EP4133065A1 (en) 2023-02-15
CA3179679A1 (en) 2021-10-14
IL296983A (en) 2022-12-01
US20230159904A1 (en) 2023-05-25
WO2021207208A1 (en) 2021-10-14
JP2023521972A (ja) 2023-05-26

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Application publication date: 20221125