JP7733443B2 - ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質 - Google Patents

ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質

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Publication number
JP7733443B2
JP7733443B2 JP2020535276A JP2020535276A JP7733443B2 JP 7733443 B2 JP7733443 B2 JP 7733443B2 JP 2020535276 A JP2020535276 A JP 2020535276A JP 2020535276 A JP2020535276 A JP 2020535276A JP 7733443 B2 JP7733443 B2 JP 7733443B2
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JP
Japan
Prior art keywords
seq
par4
set forth
antibody
binding protein
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JP2020535276A
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English (en)
Japanese (ja)
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JP2020533022A (ja
JP2020533022A5 (https=
Inventor
ハミルトン，ジャスティン
スリーマン，マーク
Original Assignee
モナシュ ユニバーシティー
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Priority claimed from AU2017903685A external-priority patent/AU2017903685A0/en
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Publication of JP2020533022A publication Critical patent/JP2020533022A/ja
Publication of JP2020533022A5 publication Critical patent/JP2020533022A5/ja
Priority to JP2023087663A priority Critical patent/JP2023116543A/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020535276A 2017-09-11 2018-09-11 ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質 Active JP7733443B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023087663A JP2023116543A (ja) 2017-09-11 2023-05-29 ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2017903685 2017-09-11
AU2017903685A AU2017903685A0 (en) 2017-09-11 Antagonists of the human thrombin receptor, PAR4
PCT/AU2018/050985 WO2019046912A1 (en) 2017-09-11 2018-09-11 HUMAN THROMBIN RECEPTOR BINDING PROTEINS, PAR4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023087663A Division JP2023116543A (ja) 2017-09-11 2023-05-29 ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質

Publications (3)

Publication Number Publication Date
JP2020533022A JP2020533022A (ja) 2020-11-19
JP2020533022A5 JP2020533022A5 (https=) 2021-10-21
JP7733443B2 true JP7733443B2 (ja) 2025-09-03

Family

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JP2020535276A Active JP7733443B2 (ja) 2017-09-11 2018-09-11 ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質
JP2023087663A Pending JP2023116543A (ja) 2017-09-11 2023-05-29 ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質

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Country Status (17)

Country Link
US (2) US11780915B2 (https=)
EP (2) EP4512469A3 (https=)
JP (2) JP7733443B2 (https=)
KR (1) KR102755742B1 (https=)
CN (1) CN111670198B (https=)
AU (1) AU2018328764B2 (https=)
CA (2) CA3075523A1 (https=)
DK (1) DK3681911T3 (https=)
ES (1) ES2999094T3 (https=)
FI (1) FI3681911T3 (https=)
HR (1) HRP20241684T1 (https=)
HU (1) HUE069649T2 (https=)
IL (1) IL273202B2 (https=)
LT (1) LT3681911T (https=)
PT (1) PT3681911T (https=)
SI (1) SI3681911T1 (https=)
WO (1) WO2019046912A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023116543A (ja) * 2017-09-11 2023-08-22 モナシュ ユニバーシティー ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112852958A (zh) * 2021-04-04 2021-05-28 吉林大学 一种检测替格瑞洛抗血小板效果的试剂盒
CN115558015B (zh) * 2022-10-12 2024-01-19 生工生物工程（上海）股份有限公司 一种从gst融合蛋白酶切后的产物中纯化无gst标签的目的蛋白的方法和产品

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023116543A (ja) * 2017-09-11 2023-08-22 モナシュ ユニバーシティー ヒトトロンビン受容体ｐａｒ４に対する結合タンパク質

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LT3681911T (lt) 2025-01-10
HRP20241684T1 (hr) 2025-02-14
AU2018328764B2 (en) 2025-01-09
DK3681911T3 (da) 2024-12-09
WO2019046912A1 (en) 2019-03-14
US12441790B2 (en) 2025-10-14
PT3681911T (pt) 2024-12-18
IL273202B2 (en) 2024-08-01
US20210179707A1 (en) 2021-06-17
US20240117031A1 (en) 2024-04-11
AU2018328764A1 (en) 2020-04-02
CA3075523A1 (en) 2019-03-14
HUE069649T2 (hu) 2025-04-28
CN111670198A (zh) 2020-09-15
ES2999094T3 (en) 2025-02-24
EP3681911B1 (en) 2024-11-27
EP4512469A2 (en) 2025-02-26
JP2023116543A (ja) 2023-08-22
CN111670198B (zh) 2023-12-15
SI3681911T1 (sl) 2025-01-31
EP4512469A3 (en) 2025-05-21
EP3681911A1 (en) 2020-07-22
IL273202A (en) 2020-04-30
CA3262851A1 (en) 2026-03-02
IL273202B1 (en) 2024-04-01
KR102755742B1 (ko) 2025-01-15
JP2020533022A (ja) 2020-11-19
FI3681911T3 (fi) 2024-12-30
EP3681911A4 (en) 2021-06-02
US11780915B2 (en) 2023-10-10
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