JP7723887B2 - 操作されたｔ細胞 - Google Patents

操作されたｔ細胞

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Publication number
JP7723887B2
JP7723887B2 JP2021566150A JP2021566150A JP7723887B2 JP 7723887 B2 JP7723887 B2 JP 7723887B2 JP 2021566150 A JP2021566150 A JP 2021566150A JP 2021566150 A JP2021566150 A JP 2021566150A JP 7723887 B2 JP7723887 B2 JP 7723887B2
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JP
Japan
Prior art keywords
polypeptide
domain
cell
intracellular signaling
cells
Prior art date
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Active
Application number
JP2021566150A
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English (en)
Japanese (ja)
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JP2022532557A5 (https=
JPWO2020227483A5 (https=
JP2022532557A (ja
Inventor
ジャスディープ マン，
クリスティアン エリンガー，
ダニエル ゾマーマイヤー，
ベンジャミン ボイェリナス，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Filing date
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Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of JP2022532557A publication Critical patent/JP2022532557A/ja
Publication of JP2022532557A5 publication Critical patent/JP2022532557A5/ja
Publication of JPWO2020227483A5 publication Critical patent/JPWO2020227483A5/ja
Priority to JP2025031484A priority Critical patent/JP2025078698A/ja
Application granted granted Critical
Publication of JP7723887B2 publication Critical patent/JP7723887B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
    • A61K39/001134—Transforming growth factor [TGF]
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
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    • C07K14/7156—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interferons [IFN]
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    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Molecular Biology (AREA)
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  • Biophysics (AREA)
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  • Toxicology (AREA)
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  • Oncology (AREA)
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  • Wood Science & Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Peptides Or Proteins (AREA)
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JP2021566150A 2019-05-08 2020-05-07 操作されたｔ細胞 Active JP7723887B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025031484A JP2025078698A (ja) 2019-05-08 2025-02-28 操作されたｔ細胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962845311P 2019-05-08 2019-05-08
US62/845,311 2019-05-08
PCT/US2020/031796 WO2020227483A1 (en) 2019-05-08 2020-05-07 Engineered t cells

Related Child Applications (1)

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JP2025031484A Division JP2025078698A (ja) 2019-05-08 2025-02-28 操作されたｔ細胞

Publications (4)

Publication Number Publication Date
JP2022532557A JP2022532557A (ja) 2022-07-15
JP2022532557A5 JP2022532557A5 (https=) 2023-05-15
JPWO2020227483A5 JPWO2020227483A5 (https=) 2023-05-15
JP7723887B2 true JP7723887B2 (ja) 2025-08-15

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JP2025031484A Pending JP2025078698A (ja) 2019-05-08 2025-02-28 操作されたｔ細胞

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Country Status (16)

Country Link
US (1) US12590136B2 (https=)
EP (1) EP3966235A4 (https=)
JP (2) JP7723887B2 (https=)
KR (1) KR20220030933A (https=)
CN (2) CN120939220A (https=)
AU (1) AU2020267641B2 (https=)
BR (1) BR112021022303A2 (https=)
CA (1) CA3139011A1 (https=)
CL (1) CL2021002935A1 (https=)
CO (1) CO2021016480A2 (https=)
EA (1) EA202193074A1 (https=)
IL (1) IL287777A (https=)
MA (1) MA55911A (https=)
MX (1) MX2021013588A (https=)
SG (1) SG11202111973RA (https=)
WO (1) WO2020227483A1 (https=)

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* Cited by examiner, † Cited by third party
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GB201604458D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against cancers
IL266628B2 (en) 2016-11-17 2024-06-01 Bluebird Bio Inc TGFBeta signal converter
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
EP3714941A1 (en) 2019-03-27 2020-09-30 Medigene Immunotherapies GmbH Mage-a4 tcrs
KR20220030933A (ko) 2019-05-08 2022-03-11 메디진 이뮤노테라피스 게엠바하 조작된 t 세포
AU2021244594A1 (en) * 2020-03-27 2022-12-01 Regeneron Pharmaceuticals, Inc. T cell receptors
JP2024514556A (ja) * 2021-04-15 2024-04-02 レジェンド バイオテック ユーエスエイ インコーポレイテッド 融合タンパク質及びその使用法
TW202317602A (zh) * 2021-07-15 2023-05-01 福瑞德哈金森腫瘤中心 嵌合多肽
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