JP7721517B2 - Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド - Google Patents
Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミドInfo
- Publication number
- JP7721517B2 JP7721517B2 JP2022527081A JP2022527081A JP7721517B2 JP 7721517 B2 JP7721517 B2 JP 7721517B2 JP 2022527081 A JP2022527081 A JP 2022527081A JP 2022527081 A JP2022527081 A JP 2022527081A JP 7721517 B2 JP7721517 B2 JP 7721517B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- substituted
- occurrences
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
- C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/222—Amides of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025126773A JP2025160375A (ja) | 2019-11-12 | 2025-07-30 | Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962934293P | 2019-11-12 | 2019-11-12 | |
| US62/934,293 | 2019-11-12 | ||
| PCT/US2020/060180 WO2021097057A1 (en) | 2019-11-12 | 2020-11-12 | 5-membered heteroarylaminosulfonamides for treating conditions mediated by deficient cftr activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025126773A Division JP2025160375A (ja) | 2019-11-12 | 2025-07-30 | Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023500408A JP2023500408A (ja) | 2023-01-05 |
| JP2023500408A5 JP2023500408A5 (enExample) | 2023-11-20 |
| JP7721517B2 true JP7721517B2 (ja) | 2025-08-12 |
Family
ID=73740547
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022527081A Active JP7721517B2 (ja) | 2019-11-12 | 2020-11-12 | Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド |
| JP2025126773A Pending JP2025160375A (ja) | 2019-11-12 | 2025-07-30 | Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025126773A Pending JP2025160375A (ja) | 2019-11-12 | 2025-07-30 | Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20240002374A1 (enExample) |
| EP (1) | EP4058439A1 (enExample) |
| JP (2) | JP7721517B2 (enExample) |
| KR (2) | KR20260078949A (enExample) |
| CN (2) | CN122562796A (enExample) |
| AU (1) | AU2020384279A1 (enExample) |
| BR (1) | BR112022009185A2 (enExample) |
| CA (1) | CA3158057A1 (enExample) |
| CL (1) | CL2022001245A1 (enExample) |
| CO (1) | CO2022007953A2 (enExample) |
| EC (1) | ECSP22046050A (enExample) |
| IL (1) | IL292966A (enExample) |
| JO (1) | JOP20220105A1 (enExample) |
| MX (1) | MX2022005809A (enExample) |
| PE (1) | PE20221461A1 (enExample) |
| PH (1) | PH12022551139A1 (enExample) |
| WO (1) | WO2021097057A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS64018B1 (sr) | 2018-02-15 | 2023-03-31 | Vertex Pharma | Makrocikli kao modulatori transmembranskog regulatora provodnosti cistične fibroze, njihove farmaceutske kompozicije, njihova upotreba u lečenju cistične fibroze i proces njihove izrade |
| TWI848092B (zh) | 2019-04-03 | 2024-07-11 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白調節劑 |
| US11873300B2 (en) | 2019-08-14 | 2024-01-16 | Vertex Pharmaceuticals Incorporated | Crystalline forms of CFTR modulators |
| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| TWI899097B (zh) | 2019-08-14 | 2025-10-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| MX2022005810A (es) | 2019-11-12 | 2022-06-08 | Genzyme Corp | Heteroarilaminosulfonamidas de 6 miembros para tratar enfermedades y afecciones mediadas por la actividad de regulador de la conductancia transmembrana de la fibrosis quistica (cftr) deficiente. |
| WO2021113806A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
| WO2021113808A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Cftr-modulating arylamides |
| WO2021113809A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
| WO2022076628A1 (en) * | 2020-10-07 | 2022-04-14 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| MX2023006770A (es) | 2020-12-10 | 2023-08-14 | Vertex Pharma | Metodos de tratamiento para fibrosis quistica. |
| CN113480416B (zh) * | 2021-07-12 | 2023-03-21 | 重庆大学 | 一种芳基酮的制备方法 |
| IL315190A (en) | 2022-03-30 | 2024-10-01 | Ishihara Sangyo Kaisha | A pyridazinone compound or a salt thereof and a pesticide containing them |
| CN114835655A (zh) * | 2022-04-14 | 2022-08-02 | 河南师范大学 | 一种合成光学活性三氟甲基丙烯酸酯类化合物的方法 |
| EP4611742A1 (en) | 2022-10-31 | 2025-09-10 | Sionna Therapeutics Inc. | Methods of treating cftr-mediated diseases or disorders |
| EP4746882A1 (en) * | 2023-07-20 | 2026-05-27 | CeMM - Forschungszentrum für Molekulare Medizin GmbH | Inhibitors of smndc1 and their therapeutic use |
| CN122374316A (zh) | 2023-10-04 | 2026-07-10 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调控因子的调节剂 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007504255A (ja) | 2003-09-06 | 2007-03-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターの調節因子 |
| JP2017074057A (ja) | 2011-06-10 | 2017-04-20 | メディミューン，エルエルシー | 抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）Ｐｓｌ結合分子およびその使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU654125B2 (en) * | 1991-03-07 | 1994-10-27 | Hisamitsu Pharmaceutical Co., Inc. | Novel diphenylthyazole derivative |
| EP0790057B1 (en) * | 1994-11-29 | 2002-06-05 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial or bactericide comprising 2-aminothiazole derivative and salts thereof |
| JP2005510508A (ja) * | 2001-11-08 | 2005-04-21 | 藤沢薬品工業株式会社 | アデノシンアンタゴニストとしてのチアゾールピリダジノン類 |
| WO2016183173A1 (en) * | 2015-05-12 | 2016-11-17 | Avista Pharma Solutions | Antiparasitic compounds |
| US10138227B2 (en) * | 2016-06-03 | 2018-11-27 | Abbvie S.Á.R.L. | Heteroaryl substituted pyridines and methods of use |
| TW201811766A (zh) * | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
| EP4611742A1 (en) * | 2022-10-31 | 2025-09-10 | Sionna Therapeutics Inc. | Methods of treating cftr-mediated diseases or disorders |
-
2020
- 2020-11-12 CA CA3158057A patent/CA3158057A1/en active Pending
- 2020-11-12 MX MX2022005809A patent/MX2022005809A/es unknown
- 2020-11-12 CN CN202610573511.5A patent/CN122562796A/zh active Pending
- 2020-11-12 EP EP20820656.5A patent/EP4058439A1/en active Pending
- 2020-11-12 BR BR112022009185A patent/BR112022009185A2/pt unknown
- 2020-11-12 AU AU2020384279A patent/AU2020384279A1/en active Pending
- 2020-11-12 CN CN202080092755.2A patent/CN115003659B/zh active Active
- 2020-11-12 PE PE2022000772A patent/PE20221461A1/es unknown
- 2020-11-12 JP JP2022527081A patent/JP7721517B2/ja active Active
- 2020-11-12 KR KR1020267014545A patent/KR20260078949A/ko active Pending
- 2020-11-12 IL IL292966A patent/IL292966A/en unknown
- 2020-11-12 WO PCT/US2020/060180 patent/WO2021097057A1/en not_active Ceased
- 2020-11-12 KR KR1020227019502A patent/KR102964196B1/ko active Active
- 2020-11-12 PH PH1/2022/551139A patent/PH12022551139A1/en unknown
-
2022
- 2022-05-10 JO JOP/2022/0105A patent/JOP20220105A1/ar unknown
- 2022-05-11 US US17/742,169 patent/US20240002374A1/en active Pending
- 2022-05-12 CL CL2022001245A patent/CL2022001245A1/es unknown
- 2022-06-03 CO CONC2022/0007953A patent/CO2022007953A2/es unknown
- 2022-06-09 EC ECSENADI202246050A patent/ECSP22046050A/es unknown
-
2025
- 2025-07-30 JP JP2025126773A patent/JP2025160375A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007504255A (ja) | 2003-09-06 | 2007-03-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターの調節因子 |
| JP2017074057A (ja) | 2011-06-10 | 2017-04-20 | メディミューン，エルエルシー | 抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）Ｐｓｌ結合分子およびその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102964196B1 (ko) | 2026-05-14 |
| EP4058439A1 (en) | 2022-09-21 |
| AU2020384279A1 (en) | 2022-05-26 |
| CA3158057A1 (en) | 2021-05-20 |
| WO2021097057A1 (en) | 2021-05-20 |
| US20240002374A1 (en) | 2024-01-04 |
| CN122562796A (zh) | 2026-08-14 |
| JP2025160375A (ja) | 2025-10-22 |
| MX2022005809A (es) | 2022-06-08 |
| ECSP22046050A (es) | 2022-08-31 |
| JOP20220105A1 (ar) | 2023-01-30 |
| CN115003659A (zh) | 2022-09-02 |
| KR20220115829A (ko) | 2022-08-18 |
| CO2022007953A2 (es) | 2022-09-09 |
| CL2022001245A1 (es) | 2023-03-10 |
| IL292966A (en) | 2022-07-01 |
| CN115003659B (zh) | 2026-04-21 |
| KR20260078949A (ko) | 2026-05-29 |
| BR112022009185A2 (pt) | 2022-07-26 |
| PH12022551139A1 (en) | 2023-07-17 |
| JP2023500408A (ja) | 2023-01-05 |
| PE20221461A1 (es) | 2022-09-21 |
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