JP7721517B2 - Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド - Google Patents

Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド

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Publication number
JP7721517B2
JP7721517B2 JP2022527081A JP2022527081A JP7721517B2 JP 7721517 B2 JP7721517 B2 JP 7721517B2 JP 2022527081 A JP2022527081 A JP 2022527081A JP 2022527081 A JP2022527081 A JP 2022527081A JP 7721517 B2 JP7721517 B2 JP 7721517B2
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Japan
Prior art keywords
alkyl
compound
substituted
occurrences
disease
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JP2022527081A
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Japanese (ja)
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JP2023500408A (ja
JP2023500408A5 (OSRAM
Inventor
ジュンカイ リャオ
マーク マンソン
ジョンリー ガオ
グレゴリー ハールバト
シルヴィー バルツァー
ベルトラン ヴィヴェ
ブライアン フリード
ハンス ペーター ネスラー
ヘレン ヨーマン
イングリッド メシャン
マルティン スムルチナ
ニーナ マ
シルヴァン ルブルトン
ライアン ハルトゥング
ウィリアム ワイアー
スカンティニ テュライラトナム
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Genzyme Corp
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Genzyme Corp
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Publication of JP2023500408A publication Critical patent/JP2023500408A/ja
Publication of JP2023500408A5 publication Critical patent/JP2023500408A5/ja
Priority to JP2025126773A priority Critical patent/JP2025160375A/ja
Application granted granted Critical
Publication of JP7721517B2 publication Critical patent/JP7721517B2/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/222—Amides of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
JP2022527081A 2019-11-12 2020-11-12 Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド Active JP7721517B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025126773A JP2025160375A (ja) 2019-11-12 2025-07-30 Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962934293P 2019-11-12 2019-11-12
US62/934,293 2019-11-12
PCT/US2020/060180 WO2021097057A1 (en) 2019-11-12 2020-11-12 5-membered heteroarylaminosulfonamides for treating conditions mediated by deficient cftr activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025126773A Division JP2025160375A (ja) 2019-11-12 2025-07-30 Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド

Publications (3)

Publication Number Publication Date
JP2023500408A JP2023500408A (ja) 2023-01-05
JP2023500408A5 JP2023500408A5 (OSRAM) 2023-11-20
JP7721517B2 true JP7721517B2 (ja) 2025-08-12

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Family Applications (2)

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JP2022527081A Active JP7721517B2 (ja) 2019-11-12 2020-11-12 Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド
JP2025126773A Pending JP2025160375A (ja) 2019-11-12 2025-07-30 Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド

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JP2025126773A Pending JP2025160375A (ja) 2019-11-12 2025-07-30 Ｃｆｔｒ活性の欠損が介在する状態を治療するための５員ヘテロアリールアミノスルホンアミド

Country Status (16)

Country Link
US (1) US20240002374A1 (OSRAM)
EP (1) EP4058439A1 (OSRAM)
JP (2) JP7721517B2 (OSRAM)
CN (1) CN115003659B (OSRAM)
AU (1) AU2020384279A1 (OSRAM)
BR (1) BR112022009185A2 (OSRAM)
CA (1) CA3158057A1 (OSRAM)
CL (1) CL2022001245A1 (OSRAM)
CO (1) CO2022007953A2 (OSRAM)
EC (1) ECSP22046050A (OSRAM)
IL (1) IL292966A (OSRAM)
JO (1) JOP20220105A1 (OSRAM)
MX (1) MX2022005809A (OSRAM)
PE (1) PE20221461A1 (OSRAM)
PH (1) PH12022551139A1 (OSRAM)
WO (1) WO2021097057A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3088577A1 (en) 2018-02-15 2019-08-22 Vertex Pharmaceuticals Incorporated Macrocycles as modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions thereof, their use in the treatment of cycstic fibrosis, and process for making them
TWI848092B (zh) 2019-04-03 2024-07-11 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白調節劑
US11873300B2 (en) 2019-08-14 2024-01-16 Vertex Pharmaceuticals Incorporated Crystalline forms of CFTR modulators
TWI899097B (zh) 2019-08-14 2025-10-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
TWI867024B (zh) 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
CA3157798A1 (en) 2019-11-12 2021-05-20 Zhongli Gao 6-membered heteroarylaminosulfonamides for treating diseases and conditions mediated by deficient cftr activity
EP4225737A1 (en) * 2020-10-07 2023-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
IL303519A (en) 2020-12-10 2023-08-01 Vertex Pharma Cystic fibrosis treatment methods
CN113480416B (zh) * 2021-07-12 2023-03-21 重庆大学 一种芳基酮的制备方法
WO2023189602A1 (ja) 2022-03-30 2023-10-05 石原産業株式会社 ピリダジノン系化合物又はその塩及びそれらを含有する有害生物防除剤
CN114835655A (zh) * 2022-04-14 2022-08-02 河南师范大学 一种合成光学活性三氟甲基丙烯酸酯类化合物的方法
WO2024097227A1 (en) 2022-10-31 2024-05-10 Sionna Therapeutics Methods of treating cftr-mediated diseases or disorders
WO2025017207A1 (en) * 2023-07-20 2025-01-23 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Inhibitors of smndc1 and their therapeutic use
WO2025076235A1 (en) 2023-10-04 2025-04-10 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator

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JP2007504255A (ja) 2003-09-06 2007-03-01 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ａｔｐ結合カセットトランスポーターの調節因子
JP2017074057A (ja) 2011-06-10 2017-04-20 メディミューン，エルエルシー 抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）Ｐｓｌ結合分子およびその使用

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US10138227B2 (en) * 2016-06-03 2018-11-27 Abbvie S.Á.R.L. Heteroaryl substituted pyridines and methods of use
TW201811766A (zh) * 2016-08-29 2018-04-01 瑞士商諾華公司 N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途
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JP2007504255A (ja) 2003-09-06 2007-03-01 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ａｔｐ結合カセットトランスポーターの調節因子
JP2017074057A (ja) 2011-06-10 2017-04-20 メディミューン，エルエルシー 抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）Ｐｓｌ結合分子およびその使用

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AU2020384279A1 (en) 2022-05-26
PE20221461A1 (es) 2022-09-21
CA3158057A1 (en) 2021-05-20
BR112022009185A2 (pt) 2022-07-26
CO2022007953A2 (es) 2022-09-09
IL292966A (en) 2022-07-01
PH12022551139A1 (en) 2023-07-17
JP2023500408A (ja) 2023-01-05
CN115003659B (zh) 2026-04-21
JOP20220105A1 (ar) 2023-01-30
CN115003659A (zh) 2022-09-02
US20240002374A1 (en) 2024-01-04
CL2022001245A1 (es) 2023-03-10
ECSP22046050A (es) 2022-08-31
WO2021097057A1 (en) 2021-05-20
JP2025160375A (ja) 2025-10-22
KR20220115829A (ko) 2022-08-18
MX2022005809A (es) 2022-06-08
EP4058439A1 (en) 2022-09-21

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