JP7721500B2 - Ｍａｇｅ－ａ４特異性を有するキメラ抗原受容体およびそれらの使用 - Google Patents

Ｍａｇｅ－ａ４特異性を有するキメラ抗原受容体およびそれらの使用

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Publication number
JP7721500B2
JP7721500B2 JP2022504107A JP2022504107A JP7721500B2 JP 7721500 B2 JP7721500 B2 JP 7721500B2 JP 2022504107 A JP2022504107 A JP 2022504107A JP 2022504107 A JP2022504107 A JP 2022504107A JP 7721500 B2 JP7721500 B2 JP 7721500B2
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cells
mage
seq
domain
chimeric antigen
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JP2022542559A5 (https=
JP2022542559A (ja
Inventor
ケヴィン・ブレイ
フランク・デルフィーノ
デーヴィッド・ディリロ
トーマス・クレイグ・ミーハー
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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JP2022504107A 2019-07-24 2020-07-24 Ｍａｇｅ－ａ４特異性を有するキメラ抗原受容体およびそれらの使用 Active JP7721500B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962878125P 2019-07-24 2019-07-24
US62/878,125 2019-07-24
US202063020177P 2020-05-05 2020-05-05
US63/020,177 2020-05-05
US202063021407P 2020-05-07 2020-05-07
US63/021,407 2020-05-07
PCT/US2020/043567 WO2021016585A1 (en) 2019-07-24 2020-07-24 Chimeric antigen receptors with mage-a4 specificity and uses thereof

Publications (3)

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JP2022542559A JP2022542559A (ja) 2022-10-05
JP2022542559A5 JP2022542559A5 (https=) 2023-07-31
JP7721500B2 true JP7721500B2 (ja) 2025-08-12

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US (1) US12600793B2 (https=)
EP (1) EP4004049A1 (https=)
JP (1) JP7721500B2 (https=)
KR (1) KR20220038397A (https=)
CN (1) CN114174345B (https=)
AU (1) AU2020316516A1 (https=)
BR (1) BR112022001194A2 (https=)
CA (1) CA3147903A1 (https=)
CL (1) CL2022000130A1 (https=)
CO (1) CO2022000451A2 (https=)
IL (1) IL289820A (https=)
MX (1) MX2022000896A (https=)
PH (1) PH12022550102A1 (https=)
WO (1) WO2021016585A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210104772A (ko) 2018-12-14 2021-08-25 블루버드 바이오, 인코포레이티드. 이량체화제로 조절된 면역수용체 복합체
JP7674278B2 (ja) 2019-07-03 2025-05-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗ニューヨーク食道扁平上皮がん１（ｎｙ－ｅｓｏ－１）抗原結合タンパク質およびその使用方法
EP4004049A1 (en) 2019-07-24 2022-06-01 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors with mage-a4 specificity and uses thereof
KR20230025662A (ko) 2020-05-05 2023-02-22 리제너론 파마슈티칼스 인코포레이티드 Cd28 제타 및 cd3 제타를 포함하는 car
MX2023010541A (es) * 2021-03-09 2023-11-24 Cdr Life Ag Proteinas de union al antigeno del peptido del mhc mage-a4.
US12435444B2 (en) 2021-03-09 2025-10-07 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same
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JP2024525727A (ja) * 2021-07-14 2024-07-12 ２セブンティ バイオ インコーポレイテッド 抗体由来の結合ドメインに融合した操作されたｔ細胞受容体
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