IL289820A - Mage-a4-specific chimeric antigen receptors and their uses - Google Patents

Mage-a4-specific chimeric antigen receptors and their uses

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Publication number
IL289820A
IL289820A IL289820A IL28982022A IL289820A IL 289820 A IL289820 A IL 289820A IL 289820 A IL289820 A IL 289820A IL 28982022 A IL28982022 A IL 28982022A IL 289820 A IL289820 A IL 289820A
Authority
IL
Israel
Prior art keywords
mage
specificity
chimeric antigen
antigen receptors
receptors
Prior art date
Application number
IL289820A
Other languages
English (en)
Hebrew (he)
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of IL289820A publication Critical patent/IL289820A/en

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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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IL289820A 2019-07-24 2022-01-13 Mage-a4-specific chimeric antigen receptors and their uses IL289820A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962878125P 2019-07-24 2019-07-24
US202063020177P 2020-05-05 2020-05-05
US202063021407P 2020-05-07 2020-05-07
PCT/US2020/043567 WO2021016585A1 (en) 2019-07-24 2020-07-24 Chimeric antigen receptors with mage-a4 specificity and uses thereof

Publications (1)

Publication Number Publication Date
IL289820A true IL289820A (en) 2022-03-01

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IL289820A IL289820A (en) 2019-07-24 2022-01-13 Mage-a4-specific chimeric antigen receptors and their uses

Country Status (14)

Country Link
US (1) US12600793B2 (https=)
EP (1) EP4004049A1 (https=)
JP (1) JP7721500B2 (https=)
KR (1) KR20220038397A (https=)
CN (1) CN114174345B (https=)
AU (1) AU2020316516A1 (https=)
BR (1) BR112022001194A2 (https=)
CA (1) CA3147903A1 (https=)
CL (1) CL2022000130A1 (https=)
CO (1) CO2022000451A2 (https=)
IL (1) IL289820A (https=)
MX (1) MX2022000896A (https=)
PH (1) PH12022550102A1 (https=)
WO (1) WO2021016585A1 (https=)

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KR20210104772A (ko) 2018-12-14 2021-08-25 블루버드 바이오, 인코포레이티드. 이량체화제로 조절된 면역수용체 복합체
JP7674278B2 (ja) 2019-07-03 2025-05-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗ニューヨーク食道扁平上皮がん１（ｎｙ－ｅｓｏ－１）抗原結合タンパク質およびその使用方法
EP4004049A1 (en) 2019-07-24 2022-06-01 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors with mage-a4 specificity and uses thereof
KR20230025662A (ko) 2020-05-05 2023-02-22 리제너론 파마슈티칼스 인코포레이티드 Cd28 제타 및 cd3 제타를 포함하는 car
MX2023010541A (es) * 2021-03-09 2023-11-24 Cdr Life Ag Proteinas de union al antigeno del peptido del mhc mage-a4.
US12435444B2 (en) 2021-03-09 2025-10-07 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same
AU2022271212A1 (en) * 2021-05-04 2023-11-30 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors with mage-a4 specificity and uses thereof
JP2024525727A (ja) * 2021-07-14 2024-07-12 ２セブンティ バイオ インコーポレイテッド 抗体由来の結合ドメインに融合した操作されたｔ細胞受容体
IL310057A (en) * 2021-07-21 2024-03-01 Immunitybio Inc Generation of chimeric antigen receptor mRNA molecules for expression in primary NK cells
CA3264474A1 (en) * 2022-09-14 2024-03-21 Cdr-Life Ag MAGE-A4 DOUBLE T LYMPHOCYTE ENGAGEMENT

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