JP7721142B2 - Ｍａｓｐ－２阻害剤および使用方法 - Google Patents
Ｍａｓｐ－２阻害剤および使用方法Info
- Publication number
- JP7721142B2 JP7721142B2 JP2022533447A JP2022533447A JP7721142B2 JP 7721142 B2 JP7721142 B2 JP 7721142B2 JP 2022533447 A JP2022533447 A JP 2022533447A JP 2022533447 A JP2022533447 A JP 2022533447A JP 7721142 B2 JP7721142 B2 JP 7721142B2
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- compound
- unsubstituted
- aryl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962943629P | 2019-12-04 | 2019-12-04 | |
| US62/943,629 | 2019-12-04 | ||
| PCT/US2020/063391 WO2021113698A1 (en) | 2019-12-04 | 2020-12-04 | Masp-2 inhibitors and methods of use |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023504541A JP2023504541A (ja) | 2023-02-03 |
| JP2023504541A5 JP2023504541A5 (https=) | 2023-10-05 |
| JPWO2021113698A5 JPWO2021113698A5 (https=) | 2023-10-05 |
| JP7721142B2 true JP7721142B2 (ja) | 2025-08-12 |
Family
ID=74106147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022533447A Active JP7721142B2 (ja) | 2019-12-04 | 2020-12-04 | Ｍａｓｐ－２阻害剤および使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US12030853B2 (https=) |
| EP (1) | EP4069676A1 (https=) |
| JP (1) | JP7721142B2 (https=) |
| AU (1) | AU2020395306B2 (https=) |
| CA (1) | CA3159159A1 (https=) |
| WO (1) | WO2021113698A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112867706B (zh) | 2018-05-29 | 2024-11-15 | 奥默罗斯公司 | Masp-2抑制剂和使用方法 |
| IL293550A (en) | 2019-12-04 | 2022-08-01 | Omeros Corp | 2-masp inhibitor compounds, preparations containing them and their uses |
| JP7699389B2 (ja) | 2019-12-04 | 2025-06-27 | オメロス コーポレーション | Ｍａｓｐ－２阻害剤および使用方法 |
| BR112022010881A2 (pt) | 2019-12-04 | 2022-08-23 | Omeros Corp | Composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio associado a serina protease-2 associada à lectina de ligação ao manan |
| EP4069676A1 (en) * | 2019-12-04 | 2022-10-12 | Omeros Corporation | Masp-2 inhibitors and methods of use |
| TWI834025B (zh) | 2020-03-06 | 2024-03-01 | 美商奥默羅斯公司 | 用於治療和/或預防冠狀病毒誘導的急性呼吸窘迫症候群的抑制masp-2的方法 |
Citations (6)
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| JP2010515729A (ja) | 2007-01-10 | 2010-05-13 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤としての化合物および組成物 |
| JP2014506877A (ja) | 2011-01-04 | 2014-03-20 | ノバルティス アーゲー | 加齢性黄斑変性症（ａｍｄ）の処置に有用なインドール化合物またはそのアナログ |
| JP2017508789A (ja) | 2014-02-25 | 2017-03-30 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 補体媒介障害の治療のための化合物 |
| WO2019186164A1 (en) | 2018-03-29 | 2019-10-03 | University Of Leeds | Factor xiia inhibitors |
| WO2019211585A1 (en) | 2018-04-30 | 2019-11-07 | University Of Leeds | FACTOR XIIa INHIBITORS |
| JP2022552048A (ja) | 2019-08-21 | 2022-12-15 | カルビスタ・ファーマシューティカルズ・リミテッド | 酵素阻害剤 |
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| CN112867706B (zh) | 2018-05-29 | 2024-11-15 | 奥默罗斯公司 | Masp-2抑制剂和使用方法 |
| IL293550A (en) | 2019-12-04 | 2022-08-01 | Omeros Corp | 2-masp inhibitor compounds, preparations containing them and their uses |
| EP4069676A1 (en) * | 2019-12-04 | 2022-10-12 | Omeros Corporation | Masp-2 inhibitors and methods of use |
| JP7699389B2 (ja) | 2019-12-04 | 2025-06-27 | オメロス コーポレーション | Ｍａｓｐ－２阻害剤および使用方法 |
| BR112022010881A2 (pt) | 2019-12-04 | 2022-08-23 | Omeros Corp | Composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio associado a serina protease-2 associada à lectina de ligação ao manan |
-
2020
- 2020-12-04 EP EP20834036.4A patent/EP4069676A1/en active Pending
- 2020-12-04 AU AU2020395306A patent/AU2020395306B2/en active Active
- 2020-12-04 WO PCT/US2020/063391 patent/WO2021113698A1/en not_active Ceased
- 2020-12-04 JP JP2022533447A patent/JP7721142B2/ja active Active
- 2020-12-04 CA CA3159159A patent/CA3159159A1/en active Pending
- 2020-12-04 US US17/112,873 patent/US12030853B2/en active Active
-
2024
- 2024-05-31 US US18/680,563 patent/US20240317682A1/en active Pending
- 2024-05-31 US US18/679,774 patent/US20240351980A1/en active Pending
-
2025
- 2025-03-05 US US19/071,565 patent/US20250197349A1/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010515729A (ja) | 2007-01-10 | 2010-05-13 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤としての化合物および組成物 |
| JP2014506877A (ja) | 2011-01-04 | 2014-03-20 | ノバルティス アーゲー | 加齢性黄斑変性症（ａｍｄ）の処置に有用なインドール化合物またはそのアナログ |
| JP2017508789A (ja) | 2014-02-25 | 2017-03-30 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 補体媒介障害の治療のための化合物 |
| WO2019186164A1 (en) | 2018-03-29 | 2019-10-03 | University Of Leeds | Factor xiia inhibitors |
| WO2019211585A1 (en) | 2018-04-30 | 2019-11-07 | University Of Leeds | FACTOR XIIa INHIBITORS |
| JP2022552048A (ja) | 2019-08-21 | 2022-12-15 | カルビスタ・ファーマシューティカルズ・リミテッド | 酵素阻害剤 |
Non-Patent Citations (1)
| Title |
|---|
| REGISTRY(STN)[online]，2011.12.05-2004.09.21, [検索日] 2024.07.31 CAS登録番号 749177-11-5, 1348395-03-8, 1348431-17-3, 1348728-96-0, 1348730-54-0 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240351980A1 (en) | 2024-10-24 |
| JP2023504541A (ja) | 2023-02-03 |
| US20240317682A1 (en) | 2024-09-26 |
| US20210171461A1 (en) | 2021-06-10 |
| US12030853B2 (en) | 2024-07-09 |
| EP4069676A1 (en) | 2022-10-12 |
| AU2020395306B2 (en) | 2025-04-24 |
| WO2021113698A1 (en) | 2021-06-10 |
| AU2020395306A1 (en) | 2022-06-30 |
| US20250197349A1 (en) | 2025-06-19 |
| CA3159159A1 (en) | 2021-06-10 |
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