AU2020395306B2 - MASP-2 inhibitors and methods of use - Google Patents

MASP-2 inhibitors and methods of use Download PDF

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Publication number
AU2020395306B2
AU2020395306B2 AU2020395306A AU2020395306A AU2020395306B2 AU 2020395306 B2 AU2020395306 B2 AU 2020395306B2 AU 2020395306 A AU2020395306 A AU 2020395306A AU 2020395306 A AU2020395306 A AU 2020395306A AU 2020395306 B2 AU2020395306 B2 AU 2020395306B2
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Australia
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substituted
unsubstituted
heterocyclyl
heteroaryl
compound
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AU2020395306A
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AU2020395306A1 (en
Inventor
Neil S. Cutshall
Jennifer Lynn Gage
Sara Rebecca GOLDSTEIN
Do Yeon Kwon
Thomas L. Little
Markus Metz
Peter Kurt NOLLERT VON SPECHT
Jennifer TSOUNG
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Omeros Corp
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Omeros Medical Systems Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2020395306A 2019-12-04 2020-12-04 MASP-2 inhibitors and methods of use Active AU2020395306B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962943629P 2019-12-04 2019-12-04
US62/943,629 2019-12-04
PCT/US2020/063391 WO2021113698A1 (en) 2019-12-04 2020-12-04 Masp-2 inhibitors and methods of use

Publications (2)

Publication Number Publication Date
AU2020395306A1 AU2020395306A1 (en) 2022-06-30
AU2020395306B2 true AU2020395306B2 (en) 2025-04-24

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AU2020395306A Active AU2020395306B2 (en) 2019-12-04 2020-12-04 MASP-2 inhibitors and methods of use

Country Status (6)

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US (4) US12030853B2 (https=)
EP (1) EP4069676A1 (https=)
JP (1) JP7721142B2 (https=)
AU (1) AU2020395306B2 (https=)
CA (1) CA3159159A1 (https=)
WO (1) WO2021113698A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL311042B1 (en) 2018-05-29 2026-04-01 Omeros Corp MASP-2 inhibitors and methods of use
EP4069676A1 (en) * 2019-12-04 2022-10-12 Omeros Corporation Masp-2 inhibitors and methods of use
IL293588B1 (en) 2019-12-04 2026-04-01 Omeros Corp 3-Amino-1-methylpyrazin-2(H1)-one derivatives as MASP-2 inhibitors, compositions containing them and uses thereof
EP4069678A1 (en) 2019-12-04 2022-10-12 Omeros Corporation Masp-2 inhibitors and methods of use
BR112022010895A2 (pt) 2019-12-04 2022-09-06 Omeros Corp Composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio associado à serina protease-2 associada à lectina de ligação ao manan
TWI834025B (zh) 2020-03-06 2024-03-01 美商奥默羅斯公司 用於治療和/或預防冠狀病毒誘導的急性呼吸窘迫症候群的抑制masp-2的方法

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Also Published As

Publication number Publication date
EP4069676A1 (en) 2022-10-12
US20240317682A1 (en) 2024-09-26
US12030853B2 (en) 2024-07-09
US20210171461A1 (en) 2021-06-10
JP2023504541A (ja) 2023-02-03
US20250197349A1 (en) 2025-06-19
JP7721142B2 (ja) 2025-08-12
CA3159159A1 (en) 2021-06-10
AU2020395306A1 (en) 2022-06-30
WO2021113698A1 (en) 2021-06-10
US20240351980A1 (en) 2024-10-24

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