JP7717619B2 - Ｃｄ８改変ｔ細胞療法を使用するがんの治療のための組成物及び方法 - Google Patents

Ｃｄ８改変ｔ細胞療法を使用するがんの治療のための組成物及び方法

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Publication number
JP7717619B2
JP7717619B2 JP2021564498A JP2021564498A JP7717619B2 JP 7717619 B2 JP7717619 B2 JP 7717619B2 JP 2021564498 A JP2021564498 A JP 2021564498A JP 2021564498 A JP2021564498 A JP 2021564498A JP 7717619 B2 JP7717619 B2 JP 7717619B2
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cells
cd8α
sequence
seq
tcr
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JP2022531231A5 (https=
JP2022531231A (ja
JPWO2020223537A5 (https=
Inventor
バーバラ センニノ，
カイル ジャコビー，
ステファニー マンデル－キャッシュマン，
マイケル エム． デュブルイユ，
ジョン ガニョン，
アレックス フランズソフ，
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Pact Pharma Inc
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Pact Pharma Inc
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JP2021564498A 2019-05-01 2020-04-30 Ｃｄ８改変ｔ細胞療法を使用するがんの治療のための組成物及び方法 Active JP7717619B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962841748P 2019-05-01 2019-05-01
US201962841753P 2019-05-01 2019-05-01
US62/841,753 2019-05-01
US62/841,748 2019-05-01
PCT/US2020/030818 WO2020223537A1 (en) 2019-05-01 2020-04-30 Compositions and methods for the treatment of cancer using a cdb engineered t cell therapy

Publications (4)

Publication Number Publication Date
JP2022531231A JP2022531231A (ja) 2022-07-06
JP2022531231A5 JP2022531231A5 (https=) 2023-05-12
JPWO2020223537A5 JPWO2020223537A5 (https=) 2023-05-12
JP7717619B2 true JP7717619B2 (ja) 2025-08-04

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JP2021564498A Active JP7717619B2 (ja) 2019-05-01 2020-04-30 Ｃｄ８改変ｔ細胞療法を使用するがんの治療のための組成物及び方法
JP2021564500A Pending JP2022530653A (ja) 2019-05-01 2020-04-30 Ｔｅｔ２改変ｔ細胞療法を使用するがんの治療のための組成物及び方法

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US (4) US20210085720A1 (https=)
EP (2) EP3962938A4 (https=)
JP (2) JP7717619B2 (https=)
KR (2) KR20220004703A (https=)
CN (1) CN113748127B (https=)
AU (2) AU2020264484A1 (https=)
CA (2) CA3151385A1 (https=)
IL (2) IL287643A (https=)
MX (2) MX2021013225A (https=)
SG (2) SG11202111865UA (https=)
WO (3) WO2020223478A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3114788A1 (en) * 2018-09-28 2020-04-02 Memorial Sloan-Kettering Cancer Center Immunoresponsive cells expressing dominant negative fas and uses thereof
US12344656B2 (en) * 2019-09-06 2025-07-01 Crispr Therapeutics Ag Genetically engineered T cells having improved persistence in culture
WO2021216993A1 (en) * 2020-04-24 2021-10-28 Pact Pharma, Inc. Methods of determining gene editing efficiencies in cells
WO2022109277A1 (en) * 2020-11-20 2022-05-27 Pact Pharma, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TGFβRII ENGINEERED T CELL THERAPY
CA3201767A1 (en) * 2020-12-14 2022-06-23 Thomas M. Schmitt Compositions and methods for cellular immunotherapy
WO2022140361A1 (en) * 2020-12-22 2022-06-30 Ludwig Institute For Cancer Research Ltd Genetically engineered lymphocytes for adoptive cell therapy
US20240108652A1 (en) * 2021-02-18 2024-04-04 University Of Florida Research Foundation, Incorporated Enhancing metabolic fitness of t cells to treat cancer
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
EP4298230A1 (en) 2021-02-25 2024-01-03 Lyell Immunopharma, Inc. Codon-optimized nucleotide sequences encoding an ap-1 transcription factor
WO2022242644A1 (zh) * 2021-05-18 2022-11-24 赛斯尔擎生物技术（上海）有限公司 修饰细胞的方法
KR20240021216A (ko) * 2021-06-11 2024-02-16 팩트 파마, 인크. 세포 생성물을 감정하는 방법
EP4405464A4 (en) * 2021-09-21 2025-12-03 Univ Chicago METHODS AND COMPOSITION USING PATIENT-DERIVED AUTOLOGOUS NEOANTIGENS FOR CANCER TREATMENT
JP2024540099A (ja) 2021-10-28 2024-10-31 ライエル・イミュノファーマ・インコーポレイテッド Ｒｏｒ１結合タンパク質を発現する細胞を培養する方法
KR20240112376A (ko) 2021-10-28 2024-07-18 라이엘 이뮤노파마, 인크. c-Jun을 발현하는 세포를 배양하는 방법
CN114373511B (zh) * 2022-03-15 2022-08-30 南方医科大学南方医院 基于5hmC分子标志物检测的肠癌模型及肠癌模型构建方法
WO2023212507A1 (en) * 2022-04-26 2023-11-02 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
WO2024026490A1 (en) 2022-07-28 2024-02-01 Sqz Biotechnologies Company Polynucleotides encoding linked antigens and uses thereof
JP2025529540A (ja) * 2022-09-19 2025-09-04 エメンドバイオ・インコーポレイテッド Ｔｅｔ２の両アレルノックアウト
CN120202302A (zh) * 2022-09-19 2025-06-24 埃门多生物公司 Ctla4双等位基因敲除
AU2023347845A1 (en) * 2022-09-19 2025-04-10 Emendobio Inc. Biallelic knockout of faslg
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
CN116179495B (zh) * 2022-11-28 2025-06-06 上海恩凯细胞技术有限公司 转基因免疫细胞及其应用
WO2025010272A1 (en) 2023-07-03 2025-01-09 Neoimmunetech, Inc. Heterodimeric fc molecules and uses thereof
WO2025027088A1 (en) * 2023-07-31 2025-02-06 T-Knife Gmbh An enhanced chimeric human cd8 co-receptor, a nucleic acid encoding the enhanced chimeric human cd8 co-receptor, corresponding vectors, isolated t-cells transduced with the nucleic acid or corresponding vectors and kits for preparing them, as well as corresponding pharmaceutical compositions and methods for treating a patient having a disease
AU2024332117A1 (en) * 2023-08-25 2026-02-12 T-Knife Gmbh Chimeric human cd 95 switch receptor, t-cell expressing said receptor together with an engineered t-cell receptor, respective vectors, kits, pharmaceutical compositions and methods for treating a patient having a disease
WO2025217398A1 (en) 2024-04-10 2025-10-16 Lyell Immunopharma, Inc. Methods for culturing cells with improved culture medium

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017538443A (ja) 2014-11-06 2017-12-28 ユニバーシティー オブ メリーランド，ボルティモア ＣＤ８αおよびＴ細胞受容体の変異体ならびに免疫細胞の応答の調節においてそれらを使用する方法
JP2018513683A (ja) 2015-04-06 2018-05-31 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答
JP2018531593A (ja) 2015-09-11 2018-11-01 アジェナス インコーポレイテッド 操作された宿主細胞及びそれらの使用方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US20020127594A1 (en) * 2000-06-22 2002-09-12 Gearing David P. Don-1 gene and polypeptides and uses therefor
US6355412B1 (en) * 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
WO2008042814A2 (en) * 2006-09-29 2008-04-10 California Institute Of Technology Mart-1 t cell receptors
US9833476B2 (en) * 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
US10316289B2 (en) * 2012-09-06 2019-06-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing T memory stem cell populations
US20160296562A1 (en) * 2013-11-21 2016-10-13 Ucl Business Plc Cell
US20180258149A1 (en) * 2015-09-17 2018-09-13 Novartis Ag Car t cell therapies with enhanced efficacy
IL297018A (en) * 2015-12-18 2022-12-01 Sangamo Therapeutics Inc Directed cleavage of cell mhc receptor
CN115109120A (zh) * 2016-04-04 2022-09-27 英蒂分子公司 Cd8-特异性捕获剂、组合物及使用和制备方法
CA3035075A1 (en) * 2016-09-23 2018-03-29 Fred Hutchinson Cancer Research Center Tcrs specific for minor histocompatibility (h) antigen ha-1 and uses thereof
KR20240024328A (ko) * 2016-11-22 2024-02-23 알로플렉스 바이오테라퓨틱스 동종이형 종양 세포 백신
MX2019010972A (es) * 2017-03-15 2019-12-02 Hutchinson Fred Cancer Res Receptores de linfocito t (tcr) específicos del antígeno asociado a melanoma 1 (mage-a1) de alta afinidad y usos de estos.
BR112019019426A2 (pt) 2017-03-22 2020-05-26 Novartis Ag Biomarcadores e terapias com células t car com eficácia intensificada
WO2018175636A2 (en) * 2017-03-22 2018-09-27 Novartis Ag Compositions and methods for immunooncology
US11512287B2 (en) * 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
US11352389B2 (en) * 2017-06-30 2022-06-07 Academisch Ziekenhuis Leiden (H.O.D.N. Leids Universitair Medisch Centrum) Treatment of haematological malignancies
AU2018329741B2 (en) * 2017-09-08 2025-02-20 Poseida Therapeutics, Inc. Compositions and methods for chimeric ligand receptor (CLR)-mediated conditional gene expression
MX2020004541A (es) * 2017-10-30 2021-04-12 Pact Pharma Inc Edicion de genes de celulas primarias.
US20200338128A1 (en) * 2018-01-05 2020-10-29 Gencyte Therapeutics, Inc. Precision molecular adaptor system for car-t immunotherapy
SG11202009761YA (en) 2018-04-02 2020-10-29 Pact Pharma Inc Peptide-mhc compacts
CN113166778A (zh) * 2018-09-05 2021-07-23 葛兰素史克知识产权开发有限公司 T细胞修饰
GB201819540D0 (en) * 2018-11-30 2019-01-16 Adaptimmune Ltd T cell modification
IL316576A (en) 2019-02-12 2024-12-01 Pact Pharma Inc Preparations and methods for identifying antigen-specific T cells
WO2020243134A1 (en) * 2019-05-27 2020-12-03 Immatics US, Inc. Viral vectors and their use in adoptive cellular therapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017538443A (ja) 2014-11-06 2017-12-28 ユニバーシティー オブ メリーランド，ボルティモア ＣＤ８αおよびＴ細胞受容体の変異体ならびに免疫細胞の応答の調節においてそれらを使用する方法
JP2018513683A (ja) 2015-04-06 2018-05-31 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答
JP2018531593A (ja) 2015-09-11 2018-11-01 アジェナス インコーポレイテッド 操作された宿主細胞及びそれらの使用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Blood，2009年，114 (22)，Abstract No. 3574，<https://ashpublications.org/blood/article/114/22/3574/76340/Extracellular-Domains-of-CD8a-and-Subunits-Are>

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