AU2020264484A1 - Compositions and methods for the treatment of cancer using a CDB engineered T cell therapy - Google Patents

Compositions and methods for the treatment of cancer using a CDB engineered T cell therapy Download PDF

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AU2020264484A1
AU2020264484A1 AU2020264484A AU2020264484A AU2020264484A1 AU 2020264484 A1 AU2020264484 A1 AU 2020264484A1 AU 2020264484 A AU2020264484 A AU 2020264484A AU 2020264484 A AU2020264484 A AU 2020264484A AU 2020264484 A1 AU2020264484 A1 AU 2020264484A1
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cd8a
cell
seq
domain
extracellular domain
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Michael M. Dubreuil
Alex Franzusoff
John Gagnon
Kyle JACOBY
Stefanie MANDL-CASHMAN
Barbara SENNINO
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Adoc SSF LLC
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Adoc SSF LLC
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AU2020264484A 2019-05-01 2020-04-30 Compositions and methods for the treatment of cancer using a CDB engineered T cell therapy Pending AU2020264484A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962841748P 2019-05-01 2019-05-01
US201962841753P 2019-05-01 2019-05-01
US62/841,753 2019-05-01
US62/841,748 2019-05-01
PCT/US2020/030818 WO2020223537A1 (en) 2019-05-01 2020-04-30 Compositions and methods for the treatment of cancer using a cdb engineered t cell therapy

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AU2020264484A1 true AU2020264484A1 (en) 2021-11-04

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AU2020264484A Pending AU2020264484A1 (en) 2019-05-01 2020-04-30 Compositions and methods for the treatment of cancer using a CDB engineered T cell therapy
AU2020266579A Abandoned AU2020266579A1 (en) 2019-05-01 2020-04-30 Compositions and methods for the treatment of cancer using a TET2 engineered T cell therapy

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AU2020266579A Abandoned AU2020266579A1 (en) 2019-05-01 2020-04-30 Compositions and methods for the treatment of cancer using a TET2 engineered T cell therapy

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US (4) US20210085720A1 (https=)
EP (2) EP3962938A4 (https=)
JP (2) JP7717619B2 (https=)
KR (2) KR20220004703A (https=)
CN (1) CN113748127B (https=)
AU (2) AU2020264484A1 (https=)
CA (2) CA3151385A1 (https=)
IL (2) IL287643A (https=)
MX (2) MX2021013225A (https=)
SG (2) SG11202111865UA (https=)
WO (3) WO2020223478A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3114788A1 (en) * 2018-09-28 2020-04-02 Memorial Sloan-Kettering Cancer Center Immunoresponsive cells expressing dominant negative fas and uses thereof
US12344656B2 (en) * 2019-09-06 2025-07-01 Crispr Therapeutics Ag Genetically engineered T cells having improved persistence in culture
WO2021216993A1 (en) * 2020-04-24 2021-10-28 Pact Pharma, Inc. Methods of determining gene editing efficiencies in cells
WO2022109277A1 (en) * 2020-11-20 2022-05-27 Pact Pharma, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TGFβRII ENGINEERED T CELL THERAPY
CA3201767A1 (en) * 2020-12-14 2022-06-23 Thomas M. Schmitt Compositions and methods for cellular immunotherapy
WO2022140361A1 (en) * 2020-12-22 2022-06-30 Ludwig Institute For Cancer Research Ltd Genetically engineered lymphocytes for adoptive cell therapy
US20240108652A1 (en) * 2021-02-18 2024-04-04 University Of Florida Research Foundation, Incorporated Enhancing metabolic fitness of t cells to treat cancer
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
EP4298230A1 (en) 2021-02-25 2024-01-03 Lyell Immunopharma, Inc. Codon-optimized nucleotide sequences encoding an ap-1 transcription factor
WO2022242644A1 (zh) * 2021-05-18 2022-11-24 赛斯尔擎生物技术（上海）有限公司 修饰细胞的方法
KR20240021216A (ko) * 2021-06-11 2024-02-16 팩트 파마, 인크. 세포 생성물을 감정하는 방법
EP4405464A4 (en) * 2021-09-21 2025-12-03 Univ Chicago METHODS AND COMPOSITION USING PATIENT-DERIVED AUTOLOGOUS NEOANTIGENS FOR CANCER TREATMENT
JP2024540099A (ja) 2021-10-28 2024-10-31 ライエル・イミュノファーマ・インコーポレイテッド Ｒｏｒ１結合タンパク質を発現する細胞を培養する方法
KR20240112376A (ko) 2021-10-28 2024-07-18 라이엘 이뮤노파마, 인크. c-Jun을 발현하는 세포를 배양하는 방법
CN114373511B (zh) * 2022-03-15 2022-08-30 南方医科大学南方医院 基于5hmC分子标志物检测的肠癌模型及肠癌模型构建方法
WO2023212507A1 (en) * 2022-04-26 2023-11-02 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
WO2024026490A1 (en) 2022-07-28 2024-02-01 Sqz Biotechnologies Company Polynucleotides encoding linked antigens and uses thereof
JP2025529540A (ja) * 2022-09-19 2025-09-04 エメンドバイオ・インコーポレイテッド Ｔｅｔ２の両アレルノックアウト
CN120202302A (zh) * 2022-09-19 2025-06-24 埃门多生物公司 Ctla4双等位基因敲除
AU2023347845A1 (en) * 2022-09-19 2025-04-10 Emendobio Inc. Biallelic knockout of faslg
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
CN116179495B (zh) * 2022-11-28 2025-06-06 上海恩凯细胞技术有限公司 转基因免疫细胞及其应用
WO2025010272A1 (en) 2023-07-03 2025-01-09 Neoimmunetech, Inc. Heterodimeric fc molecules and uses thereof
WO2025027088A1 (en) * 2023-07-31 2025-02-06 T-Knife Gmbh An enhanced chimeric human cd8 co-receptor, a nucleic acid encoding the enhanced chimeric human cd8 co-receptor, corresponding vectors, isolated t-cells transduced with the nucleic acid or corresponding vectors and kits for preparing them, as well as corresponding pharmaceutical compositions and methods for treating a patient having a disease
AU2024332117A1 (en) * 2023-08-25 2026-02-12 T-Knife Gmbh Chimeric human cd 95 switch receptor, t-cell expressing said receptor together with an engineered t-cell receptor, respective vectors, kits, pharmaceutical compositions and methods for treating a patient having a disease
WO2025217398A1 (en) 2024-04-10 2025-10-16 Lyell Immunopharma, Inc. Methods for culturing cells with improved culture medium

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US20020127594A1 (en) * 2000-06-22 2002-09-12 Gearing David P. Don-1 gene and polypeptides and uses therefor
US6355412B1 (en) * 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
WO2008042814A2 (en) * 2006-09-29 2008-04-10 California Institute Of Technology Mart-1 t cell receptors
US9833476B2 (en) * 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
US10316289B2 (en) * 2012-09-06 2019-06-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing T memory stem cell populations
US20160296562A1 (en) * 2013-11-21 2016-10-13 Ucl Business Plc Cell
AU2015342867B2 (en) 2014-11-06 2020-03-26 University Of Maryland, Baltimore CD8alpha and T cell receptor variants and methods of using same in modulating immune cell responses
CN113349159B (zh) 2015-04-06 2022-11-11 瑞泽恩制药公司 非人动物中的人源化t细胞介导的免疫应答
JP2018531593A (ja) 2015-09-11 2018-11-01 アジェナス インコーポレイテッド 操作された宿主細胞及びそれらの使用方法
US20180258149A1 (en) * 2015-09-17 2018-09-13 Novartis Ag Car t cell therapies with enhanced efficacy
IL297018A (en) * 2015-12-18 2022-12-01 Sangamo Therapeutics Inc Directed cleavage of cell mhc receptor
CN115109120A (zh) * 2016-04-04 2022-09-27 英蒂分子公司 Cd8-特异性捕获剂、组合物及使用和制备方法
CA3035075A1 (en) * 2016-09-23 2018-03-29 Fred Hutchinson Cancer Research Center Tcrs specific for minor histocompatibility (h) antigen ha-1 and uses thereof
KR20240024328A (ko) * 2016-11-22 2024-02-23 알로플렉스 바이오테라퓨틱스 동종이형 종양 세포 백신
MX2019010972A (es) * 2017-03-15 2019-12-02 Hutchinson Fred Cancer Res Receptores de linfocito t (tcr) específicos del antígeno asociado a melanoma 1 (mage-a1) de alta afinidad y usos de estos.
BR112019019426A2 (pt) 2017-03-22 2020-05-26 Novartis Ag Biomarcadores e terapias com células t car com eficácia intensificada
WO2018175636A2 (en) * 2017-03-22 2018-09-27 Novartis Ag Compositions and methods for immunooncology
US11512287B2 (en) * 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
US11352389B2 (en) * 2017-06-30 2022-06-07 Academisch Ziekenhuis Leiden (H.O.D.N. Leids Universitair Medisch Centrum) Treatment of haematological malignancies
AU2018329741B2 (en) * 2017-09-08 2025-02-20 Poseida Therapeutics, Inc. Compositions and methods for chimeric ligand receptor (CLR)-mediated conditional gene expression
MX2020004541A (es) * 2017-10-30 2021-04-12 Pact Pharma Inc Edicion de genes de celulas primarias.
US20200338128A1 (en) * 2018-01-05 2020-10-29 Gencyte Therapeutics, Inc. Precision molecular adaptor system for car-t immunotherapy
SG11202009761YA (en) 2018-04-02 2020-10-29 Pact Pharma Inc Peptide-mhc compacts
CN113166778A (zh) * 2018-09-05 2021-07-23 葛兰素史克知识产权开发有限公司 T细胞修饰
GB201819540D0 (en) * 2018-11-30 2019-01-16 Adaptimmune Ltd T cell modification
IL316576A (en) 2019-02-12 2024-12-01 Pact Pharma Inc Preparations and methods for identifying antigen-specific T cells
WO2020243134A1 (en) * 2019-05-27 2020-12-03 Immatics US, Inc. Viral vectors and their use in adoptive cellular therapy

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