JP7695891B2 - ジスキネジア治療薬 - Google Patents

ジスキネジア治療薬 Download PDF

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Publication number
JP7695891B2
JP7695891B2 JP2021561833A JP2021561833A JP7695891B2 JP 7695891 B2 JP7695891 B2 JP 7695891B2 JP 2021561833 A JP2021561833 A JP 2021561833A JP 2021561833 A JP2021561833 A JP 2021561833A JP 7695891 B2 JP7695891 B2 JP 7695891B2
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JP
Japan
Prior art keywords
tandospirone
levodopa
dyskinesia
pharma
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021561833A
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English (en)
Japanese (ja)
Other versions
JP2022529661A (ja
Inventor
光將 栗田
友紀 池田
充宏 中塔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
Sumitomo Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd, Sumitomo Pharma Co Ltd filed Critical Sumitomo Dainippon Pharma Co Ltd
Publication of JP2022529661A publication Critical patent/JP2022529661A/ja
Priority to JP2025017181A priority Critical patent/JP2025072496A/ja
Application granted granted Critical
Publication of JP7695891B2 publication Critical patent/JP7695891B2/ja
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021561833A 2019-04-26 2020-04-24 ジスキネジア治療薬 Active JP7695891B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025017181A JP2025072496A (ja) 2019-04-26 2025-02-04 ジスキネジア治療薬

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/395,531 US10758535B1 (en) 2019-04-26 2019-04-26 Therapeutic drug for dyskinesia
US16/395,531 2019-04-26
PCT/JP2020/017652 WO2020218487A1 (en) 2019-04-26 2020-04-24 Therapeutic drug for dyskinesia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025017181A Division JP2025072496A (ja) 2019-04-26 2025-02-04 ジスキネジア治療薬

Publications (2)

Publication Number Publication Date
JP2022529661A JP2022529661A (ja) 2022-06-23
JP7695891B2 true JP7695891B2 (ja) 2025-06-19

Family

ID=72241591

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021561833A Active JP7695891B2 (ja) 2019-04-26 2020-04-24 ジスキネジア治療薬
JP2025017181A Pending JP2025072496A (ja) 2019-04-26 2025-02-04 ジスキネジア治療薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025017181A Pending JP2025072496A (ja) 2019-04-26 2025-02-04 ジスキネジア治療薬

Country Status (13)

Country Link
US (3) US10758535B1 (enExample)
EP (1) EP3958972A4 (enExample)
JP (2) JP7695891B2 (enExample)
KR (1) KR20220004640A (enExample)
CN (1) CN113646045A (enExample)
AU (1) AU2020260895A1 (enExample)
BR (1) BR112021021184A8 (enExample)
CA (1) CA3137400A1 (enExample)
EA (1) EA202192928A1 (enExample)
MX (1) MX2021013070A (enExample)
PH (1) PH12021552681A1 (enExample)
SG (1) SG11202111852TA (enExample)
WO (1) WO2020218487A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11559525B2 (en) 2019-04-26 2023-01-24 Sumitomo Pharma Co., Ltd. Therapeutic drug for dyskinesia
CN116113402A (zh) 2020-08-31 2023-05-12 住友制药株式会社 帕金森病的运动并发症治疗药

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060193900A1 (en) 2005-02-28 2006-08-31 Hisamitsu Pharmaceutical Co., Inc. Pressure sensitive adhesive and patch
WO2013156035A1 (en) 2012-04-18 2013-10-24 Concit Pharma Aps Orally available pharmaceutical formulation suitable for improved management of movement disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507303A (en) 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
JPH11228414A (ja) 1998-02-06 1999-08-24 Sumitomo Pharmaceut Co Ltd タンドスピロン経皮剤
US20040198753A1 (en) * 2002-01-28 2004-10-07 Hiroshi Kase Methods of treating patients suffering from movement disorders
EP1743645A4 (en) * 2004-06-01 2012-11-14 Hisamitsu Pharmaceutical Co ADHESIVE PATCH
EP1661560B1 (en) 2004-11-22 2008-11-05 Hisamitsu Pharmaceutical Co., Inc. Transdermal patch comprising a melting point lowering agent
JP5243254B2 (ja) 2006-10-11 2013-07-24 久光製薬株式会社 結晶含有貼付剤
EP2729176A1 (en) 2011-07-05 2014-05-14 Contera Pharma APS The use of serotonin receptor agonists for treatment of movement disorders
KR20210107729A (ko) * 2018-12-20 2021-09-01 콘테라 파르마 에이/에스 운동 장애의 치료

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060193900A1 (en) 2005-02-28 2006-08-31 Hisamitsu Pharmaceutical Co., Inc. Pressure sensitive adhesive and patch
WO2013156035A1 (en) 2012-04-18 2013-10-24 Concit Pharma Aps Orally available pharmaceutical formulation suitable for improved management of movement disorders

Also Published As

Publication number Publication date
EA202192928A1 (ru) 2022-02-07
JP2025072496A (ja) 2025-05-09
KR20220004640A (ko) 2022-01-11
BR112021021184A2 (enExample) 2021-12-14
CA3137400A1 (en) 2020-10-29
MX2021013070A (es) 2021-11-17
US20210060015A1 (en) 2021-03-04
AU2020260895A1 (en) 2021-12-23
EP3958972A4 (en) 2023-01-04
BR112021021184A8 (pt) 2023-02-28
PH12021552681A1 (en) 2022-09-19
SG11202111852TA (en) 2021-11-29
EP3958972A1 (en) 2022-03-02
US20220193075A1 (en) 2022-06-23
WO2020218487A1 (en) 2020-10-29
CN113646045A (zh) 2021-11-12
US10758535B1 (en) 2020-09-01
JP2022529661A (ja) 2022-06-23

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