JP7689125B2 - ヒトｉｌ－１３及びｉｌ－１７に対する結合特異性を有する多重特異性抗体 - Google Patents

ヒトｉｌ－１３及びｉｌ－１７に対する結合特異性を有する多重特異性抗体 Download PDF

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JP7689125B2
JP7689125B2 JP2022534761A JP2022534761A JP7689125B2 JP 7689125 B2 JP7689125 B2 JP 7689125B2 JP 2022534761 A JP2022534761 A JP 2022534761A JP 2022534761 A JP2022534761 A JP 2022534761A JP 7689125 B2 JP7689125 B2 JP 7689125B2
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seq
human
antibody
cdr
sequence shown
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JP2023507280A (ja
JP2023507280A5 (https=
Inventor
ラーマン カーン、アドナン
フィリップ ヘイウッド、サム
ポール ハンフリーズ、デイヴィッド
ジョン ライトウッド、ダニエル
デイブ、エマ
メアリー ケアリスティン バリー、エミリー
ジェイン スタンヨン、セアラ
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ユーシービー バイオファルマ エスアールエル
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2022534761A 2019-12-20 2020-12-18 ヒトｉｌ－１３及びｉｌ－１７に対する結合特異性を有する多重特異性抗体 Active JP7689125B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1919061.0A GB201919061D0 (en) 2019-12-20 2019-12-20 Multi-specific antibody
GB1919061.0 2019-12-20
PCT/EP2020/087046 WO2021123186A1 (en) 2019-12-20 2020-12-18 Multi-specific antibody with binding specificity for human il-13 and il-17

Publications (3)

Publication Number Publication Date
JP2023507280A JP2023507280A (ja) 2023-02-22
JP2023507280A5 JP2023507280A5 (https=) 2023-12-06
JP7689125B2 true JP7689125B2 (ja) 2025-06-05

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JP2022534761A Active JP7689125B2 (ja) 2019-12-20 2020-12-18 ヒトｉｌ－１３及びｉｌ－１７に対する結合特異性を有する多重特異性抗体

Country Status (20)

Country Link
US (1) US12570738B2 (https=)
EP (1) EP4077381A1 (https=)
JP (1) JP7689125B2 (https=)
KR (1) KR20220117307A (https=)
CN (1) CN114846026A (https=)
AR (1) AR120818A1 (https=)
AU (1) AU2020407279A1 (https=)
BR (1) BR112022011627A2 (https=)
CA (1) CA3164276A1 (https=)
CL (2) CL2022001685A1 (https=)
CO (1) CO2022009711A2 (https=)
EC (1) ECSP22054471A (https=)
GB (1) GB201919061D0 (https=)
IL (1) IL294035A (https=)
MX (1) MX2022007150A (https=)
PE (1) PE20221173A1 (https=)
PH (1) PH12022551411A1 (https=)
TW (1) TW202130365A (https=)
WO (1) WO2021123186A1 (https=)
ZA (1) ZA202207715B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6871948B2 (ja) 2016-04-27 2021-05-19 アッヴィ・インコーポレイテッド 抗ｉｌ−１３抗体を使用する、ｉｌ−１３活性が有害である疾患の治療方法
WO2025238133A1 (en) 2024-05-17 2025-11-20 UCB Biopharma SRL Multispecific antibody with binding specificity for il-11 and il-17

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Also Published As

Publication number Publication date
PH12022551411A1 (en) 2023-11-20
JP2023507280A (ja) 2023-02-22
TW202130365A (zh) 2021-08-16
US20230087378A1 (en) 2023-03-23
CN114846026A (zh) 2022-08-02
BR112022011627A2 (pt) 2022-09-13
ECSP22054471A (es) 2022-08-31
MX2022007150A (es) 2022-07-19
CA3164276A1 (en) 2021-06-24
CO2022009711A2 (es) 2022-07-19
PE20221173A1 (es) 2022-07-25
ZA202207715B (en) 2024-01-31
AU2020407279A1 (en) 2022-08-11
CL2022001685A1 (es) 2023-05-26
WO2021123186A1 (en) 2021-06-24
AR120818A1 (es) 2022-03-23
EP4077381A1 (en) 2022-10-26
GB201919061D0 (en) 2020-02-05
KR20220117307A (ko) 2022-08-23
IL294035A (en) 2022-08-01
CL2023002975A1 (es) 2024-04-01
US12570738B2 (en) 2026-03-10

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