CL2022001685A1 - Anticuerpo multiespecífico con especificidad de unión para il-13 e il-17 humanas - Google Patents

Anticuerpo multiespecífico con especificidad de unión para il-13 e il-17 humanas

Info

Publication number
CL2022001685A1
CL2022001685A1 CL2022001685A CL2022001685A CL2022001685A1 CL 2022001685 A1 CL2022001685 A1 CL 2022001685A1 CL 2022001685 A CL2022001685 A CL 2022001685A CL 2022001685 A CL2022001685 A CL 2022001685A CL 2022001685 A1 CL2022001685 A1 CL 2022001685A1
Authority
CL
Chile
Prior art keywords
human
multispecific antibody
binding specificity
specificity
relates
Prior art date
Application number
CL2022001685A
Other languages
English (en)
Inventor
John Lightwood Daniel
Rahman Khan Adnan
Philip Heywood Sam
Paul Humphreys David
Dave Emma
Mary Cairistine Barry Emily
Jayne Stanyon Sarah
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of CL2022001685A1 publication Critical patent/CL2022001685A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un anticuerpo multiespecífico que tiene especificidad para IL-13 humana, IL-17A humana y/o IL-17F humana. La invención se refiere además a métodos para producir el anticuerpo multiespecífico y a su uso terapéutico para el tratamiento de la dermatitis atópica y otras enfermedades.
CL2022001685A 2019-12-20 2022-06-17 Anticuerpo multiespecífico con especificidad de unión para il-13 e il-17 humanas CL2022001685A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1919061.0A GB201919061D0 (en) 2019-12-20 2019-12-20 Multi-specific antibody

Publications (1)

Publication Number Publication Date
CL2022001685A1 true CL2022001685A1 (es) 2023-05-26

Family

ID=69323008

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2022001685A CL2022001685A1 (es) 2019-12-20 2022-06-17 Anticuerpo multiespecífico con especificidad de unión para il-13 e il-17 humanas
CL2023002975A CL2023002975A1 (es) 2019-12-20 2023-10-04 Anticuerpo multiespecífico con especificidad de unión para il-13 e il-17 humanas

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2023002975A CL2023002975A1 (es) 2019-12-20 2023-10-04 Anticuerpo multiespecífico con especificidad de unión para il-13 e il-17 humanas

Country Status (19)

Country Link
US (1) US20230087378A1 (es)
EP (1) EP4077381A1 (es)
JP (1) JP2023507280A (es)
KR (1) KR20220117307A (es)
CN (1) CN114846026A (es)
AR (1) AR120818A1 (es)
AU (1) AU2020407279A1 (es)
BR (1) BR112022011627A2 (es)
CA (1) CA3164276A1 (es)
CL (2) CL2022001685A1 (es)
CO (1) CO2022009711A2 (es)
EC (1) ECSP22054471A (es)
GB (1) GB201919061D0 (es)
IL (1) IL294035A (es)
MX (1) MX2022007150A (es)
PE (1) PE20221173A1 (es)
TW (1) TW202130365A (es)
WO (1) WO2021123186A1 (es)
ZA (1) ZA202207715B (es)

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Also Published As

Publication number Publication date
BR112022011627A2 (pt) 2022-09-13
MX2022007150A (es) 2022-07-19
US20230087378A1 (en) 2023-03-23
PE20221173A1 (es) 2022-07-25
ZA202207715B (en) 2024-01-31
CA3164276A1 (en) 2021-06-24
JP2023507280A (ja) 2023-02-22
ECSP22054471A (es) 2022-08-31
AR120818A1 (es) 2022-03-23
CN114846026A (zh) 2022-08-02
KR20220117307A (ko) 2022-08-23
EP4077381A1 (en) 2022-10-26
WO2021123186A1 (en) 2021-06-24
AU2020407279A1 (en) 2022-08-11
IL294035A (en) 2022-08-01
GB201919061D0 (en) 2020-02-05
CO2022009711A2 (es) 2022-07-19
CL2023002975A1 (es) 2024-04-01
TW202130365A (zh) 2021-08-16

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